Evolutionary relationships among strains of Mycobacterium tuberculosis with few copies of IS6110.

Abstract:

:Molecular typing of Mycobacterium tuberculosis by using IS6110 shows low discrimination when there are fewer than five copies of the insertion sequence. Using a collection of such isolates from a study of the epidemiology of tuberculosis in London, we have shown a substantial degree of congruence between IS6110 patterns and both spoligotype and PGRS type. This indicates that the IS6110 types mainly represent distinct families of strains rather than arising through the convergent insertion of IS6110 into favored positions. This is supported by identification of the genomic sites of the insertion of IS6110 in these strains. The combined data enable identification of the putative evolutionary relationships of these strains, comprising three lineages broadly associated with patients born in South Asia (India and Pakistan), Africa, and Europe, respectively. These lineages appear to be quite distinct from M. tuberculosis isolates with multiple copies of IS6110.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Dale JW,Al-Ghusein H,Al-Hashmi S,Butcher P,Dickens AL,Drobniewski F,Forbes KJ,Gillespie SH,Lamprecht D,McHugh TD,Pitman R,Rastogi N,Smith AT,Sola C,Yesilkaya H

doi

10.1128/jb.185.8.2555-2562.2003

keywords:

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

2555-62

issue

8

eissn

0021-9193

issn

1098-5530

journal_volume

185

pub_type

杂志文章
  • An extraintestinal, pathogenic isolate of Escherichia coli (O4/K54/H5) can produce a group 1 capsule which is divergently regulated from its constitutively produced group 2, K54 capsular polysaccharide.

    abstract::We are studying an O4/K54/H5 Escherichia coli bacteremic isolate (CP9) as a model pathogen for extraintestinal infection. Its group 2, K54 capsular polysaccharide is an important virulence determinant and confers serum resistance. In this study the effect of the group 1 capsule regulators, RcsA, RcsB, and Lon protease...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.175.23.7617-7623.1993

    authors: Russo TA,Singh G

    更新日期:1993-12-01 00:00:00

  • Nitric oxide signaling in Pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic di-GMP levels, and enhanced dispersal.

    abstract::Bacteria in biofilms often undergo active dispersal events and revert to a free-swimming, planktonic state to complete the biofilm life cycle. The signaling molecule nitric oxide (NO) was previously found to trigger biofilm dispersal in the opportunistic pathogen Pseudomonas aeruginosa at low, nontoxic concentrations ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00975-09

    authors: Barraud N,Schleheck D,Klebensberger J,Webb JS,Hassett DJ,Rice SA,Kjelleberg S

    更新日期:2009-12-01 00:00:00

  • Identification of two quorum-sensing systems in Sinorhizobium meliloti.

    abstract::Sinorhizobium meliloti is a free-living soil bacterium which is capable of establishing a symbiotic relationship with the alfalfa plant (Medicago sativa). This symbiosis involves a network of bacterium-host signaling, as well as the potential for bacterium-bacterium communication, such as quorum sensing. In this study...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.184.13.3466-3475.2002

    authors: Marketon MM,González JE

    更新日期:2002-07-01 00:00:00

  • Reassociation of deoxyribonucleic acids from Actinoplanes and other actinomycetes.

    abstract::The ability of deoxyribonucleic acid (DNA) isolated from a number of actinomycetes to reassociate with reference DNA from Actinoplanes philippinensis or Streptomyces venezuelae has been measured. All of the DNA preparations except for those from Nocardia erythropolis and Thermomonospora viridis contained 70 to 73 mole...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.102.1.30-35.1970

    authors: Farina G,Bradley SG

    更新日期:1970-04-01 00:00:00

  • IS257-mediated cointegration in the evolution of a family of staphylococcal trimethoprim resistance plasmids.

    abstract::Analyses of the Staphylococcus epidermidis multiresistance plasmids pSK697 and pSK818 have revealed them to be closely related to the trimethoprim resistance plasmid pSK639, also isolated from S. epidermidis. pSK697 and pSK818 were found to contain a cointegrated copy of a second plasmid related to the S. epidermidis ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.178.20.6070-6073.1996

    authors: Leelaporn A,Firth N,Paulsen IT,Skurray RA

    更新日期:1996-10-01 00:00:00

  • Cosmid cloning of five Zymomonas trp genes by complementation of Escherichia coli and Pseudomonas putida trp mutants.

    abstract::A library of Zymomonas mobilis genomic DNA was constructed in the broad-host-range cosmid pLAFR1. The library was mobilized into a variety of Escherichia coli and Pseudomonas putida trp mutants by using the helper plasmid pRK2013. Five Z. mobilis trp genes were identified by the ability to complement the trp mutants. ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.170.7.3158-3163.1988

    authors: Eddy CK,Smith OH,Noel KD

    更新日期:1988-07-01 00:00:00

  • Studies with a gluconate-6-phosphate dehydrogenase mutant in Escherichia coli strain C.

    abstract::A map location of the gluconate-6-phosphate dehydrogenase (gnd) marker was estimated in Escherichia coli C at approximately 46 min by P1 transduction. The gnd locus appears to lie between the co-transducible histidine and prophage P2 location I markers. ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.116.2.1056-1058.1973

    authors: Robbins RS,Kelly B

    更新日期:1973-11-01 00:00:00

  • Molecular genetic analysis of a group A Streptococcus operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX.

    abstract::The group A Streptococcus (GAS) sof gene encodes the serum opacity factor protein, which is capable of opacifying mammalian sera and binding at least two host proteins, fibronectin and fibrinogen. The sof gene exists in approximately 50% of clinical isolates, and there is a classical association of so-called nephritog...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.185.4.1208-1217.2003

    authors: Jeng A,Sakota V,Li Z,Datta V,Beall B,Nizet V

    更新日期:2003-02-01 00:00:00

  • Molecular cloning, characterization, and nucleotide sequence of nit-6, the structural gene for nitrite reductase in Neurospora crassa.

    abstract::The Neurospora crassa assimilatory nitrite reductase structural gene, nit-6, has been isolated. A cDNA library was constructed from poly(A)+ RNA isolated from Neurospora mycelia in which nitrate assimilation had been induced. This cDNA was ligated into lambda ZAP II (Stratagene) and amplified. This library was then sc...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.175.8.2379-2392.1993

    authors: Exley GE,Colandene JD,Garrett RH

    更新日期:1993-04-01 00:00:00

  • Perturbation of the oxidizing environment of the periplasm stimulates the PhoQ/PhoP system in Escherichia coli.

    abstract::The PhoQ/PhoP two-component system is repressed by divalent cations, such as Mg(2+) and Ca(2+), in the growth medium and stimulated by low pH and certain cationic antimicrobial peptides. In Escherichia coli, it was recently shown that the histidine kinase PhoQ is also modulated by at least two additional factors, the ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.06055-11

    authors: Lippa AM,Goulian M

    更新日期:2012-03-01 00:00:00

  • Global gene expression analysis of the heat shock response in the phytopathogen Xylella fastidiosa.

    abstract::Xylella fastidiosa is a phytopathogenic bacterium that is responsible for diseases in many economically important crops. Although different strains have been studied, little is known about X. fastidiosa stress responses. One of the better characterized stress responses in bacteria is the heat shock response, which ind...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00182-06

    authors: Koide T,Vêncio RZ,Gomes SL

    更新日期:2006-08-01 00:00:00

  • Protein and ribonucleic acid syntheses in heat-damaged and heat-killed Escherichia coli.

    abstract::Protein and ribonucleic acid (RNA) syntheses were measured in both lethally injured and thermally damaged viable cells after heating at lethal temperatures. Immediately after heating, cells were incubated in growth media containing either [14C]leucine or [3H]uracil. The labeled cells were subsequently treated with pen...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.138.2.492-498.1979

    authors: Dean RG,McGroarty EJ

    更新日期:1979-05-01 00:00:00

  • Induction of yeast killer factor mutations.

    abstract::Two related killer strains of Saccharomyces cerevisiae were mutagenized and screened for nonkiller variants. About 20% of the mutants derived from one strain lacked all detectable double-straned ribonucleic acid (dsRNA). About 70% of the mutants from the other strain lacked one of the dsRNA species normally associated...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.132.1.346-348.1977

    authors: Vodkin M

    更新日期:1977-10-01 00:00:00

  • Three-dimensional structure of the nickel-containing hydrogenase from Thiocapsa roseopersicina.

    abstract::The three-dimensional structure of the nickel-containing hydrogenase from Thiocapsa roseopersicina has been determined at a resolution of 2 nm in the plane and 4 nm in the vertical direction by electron microscopy and computerized image processing on microcrystals of the enzyme. The enzyme forms a large ring-shaped co...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.173.8.2576-2580.1991

    authors: Sherman MB,Orlova EV,Smirnova EA,Hovmöller S,Zorin NA

    更新日期:1991-04-01 00:00:00

  • Metabolism of 6-aminonicotinic acid in Escherichia coli.

    abstract::A late-log-phase culture of an Escherichia coli nadB pncA double mutant took up 6-[7-14C]aminonicotinic acid and excreted 6-[14C]aminonicotinamide. This mutant also accumulated intracellularly several radioactive compounds which have been tentatively identified as 6-amino analogs of compounds in the pyridine nucleotid...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.131.3.789-794.1977

    authors: Cobb JR,Pearcy SC,Gholson RK

    更新日期:1977-09-01 00:00:00

  • Fatty acid composition of L-forms of Streptococcus faecalis cultured at different osmolalities.

    abstract::The fatty acid composition of the membranes of three different penicillin-produced L-forms of Streptococcus faecalis was determined: (i) a stable (nonreverting) L-form (T(53)) cultured in brain heart infusion (BHI) with 0.5 M sucrose; (ii) a stable L-form (T(531)) cultured in BHI without sucrose; and (iii) an unstable...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.115.1.73-75.1973

    authors: Montgomerie JZ,Kalmanson GM,Guze LB

    更新日期:1973-07-01 00:00:00

  • In vitro sulfotransferase activity of NodH, a nodulation protein of Rhizobium meliloti required for host-specific nodulation.

    abstract::Early stages of nodulation involve the exchange of signals between the bacterium and the host plant. Bacterial nodulation (nod) genes are required for Rhizobium spp. to synthesize lipooligosaccharide morphogens, termed Nod factors. The common nod genes encode enzymes that synthesize the factor core structure, which is...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.177.21.6237-6245.1995

    authors: Ehrhardt DW,Atkinson EM,Faull KF,Freedberg DI,Sutherlin DP,Armstrong R,Long SR

    更新日期:1995-11-01 00:00:00

  • Phage-associated mutator phenotype in group A streptococcus.

    abstract::Defects in DNA mismatch repair (MMR) occur frequently in natural populations of pathogenic and commensal bacteria, resulting in a mutator phenotype. We identified a unique genetic element in Streptococcus pyogenes strain SF370 that controls MMR via a dynamic process of prophage excision and reintegration in response t...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.01569-07

    authors: Scott J,Thompson-Mayberry P,Lahmamsi S,King CJ,McShan WM

    更新日期:2008-10-01 00:00:00

  • The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway.

    abstract::The 2-aminoethylphosphonate transaminase (AEPT; the phnW gene product) of the Salmonella enterica serovar Typhimurium 2-aminoethylphosphonate (AEP) degradation pathway catalyzes the reversible reaction of AEP and pyruvate to form phosphonoacetaldehyde (P-Ald) and L-alanine (L-Ala). Here, we describe the purification a...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.184.15.4134-4140.2002

    authors: Kim AD,Baker AS,Dunaway-Mariano D,Metcalf WW,Wanner BL,Martin BM

    更新日期:2002-08-01 00:00:00

  • Phenotypic switching of Thiobacillus ferrooxidans.

    abstract::Two solid medium formulations, designated 100:10 and 10:10, were developed for the growth of Thiobacillus ferrooxidans. The new media contain a mixture of both ferrous iron and thiosulfate as available energy sources, permitting the detection of colony morphology variants that arise spontaneously in a wild-type popula...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.170.9.3915-3923.1988

    authors: Schrader JA,Holmes DS

    更新日期:1988-09-01 00:00:00

  • Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli.

    abstract::The rcs phosphorelay pathway components were originally identified as regulators of capsule synthesis. In addition to the transmembrane sensor kinase RcsC, the RcsA coregulator, and the response regulator RcsB, two new components have been characterized, RcsD and RcsF. RcsD, the product of the yojN gene, now renamed r...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.187.19.6770-6778.2005

    authors: Majdalani N,Heck M,Stout V,Gottesman S

    更新日期:2005-10-01 00:00:00

  • Independent regulation of synthesis of form I and form II ribulose bisphosphate carboxylase-oxygenase in Rhodopseudomonas sphaeroides.

    abstract::Ribulose 1,5-bisphosphate carboxylase-oxygenase (RuBPC-O) activity was greatly enhanced when Rhodopseudomonas sphaeroides was grown in a mineral salts medium supplied with 1.5% CO2 in hydrogen. Analysis of cell extracts by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that cells growing on 1.5% C...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.165.2.620-624.1986

    authors: Jouanneau Y,Tabita FR

    更新日期:1986-02-01 00:00:00

  • Assembly of the mitochondrial membrane system: isolation of nuclear and cytoplasmic mutants of Saccharomyces cerevisiae with specific defects in mitochondrial functions.

    abstract::A selection procedure is described which permits a large number of Saccharomyces cerevisiae mutants to be screened for specific lesions in mitochondrial respiratory enzymes and the adenosine triphosphatase. The method has been used to isolate nuclear mutant strains with specific lesions in coenzyme QH2-cytochrome c re...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.122.3.826-831.1975

    authors: Tzagoloff A,Akai A,Needleman RB

    更新日期:1975-06-01 00:00:00

  • Metabolism of endogenous trehalose by Streptomyces griseus spores and by spores or cells of other actinomycetes.

    abstract::The disaccharide trehalose is accumulated as a storage product by spores of Streptomyces griseus. Nongerminating spores used their trehalose reserves slowly when incubated in buffer for several months. In contrast, spores rapidly depleted their trehalose pools during the first hours of germination. Extracts of dormant...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.169.11.5002-5007.1987

    authors: McBride MJ,Ensign JC

    更新日期:1987-11-01 00:00:00

  • Murein structure and lack of DD- and LD-carboxypeptidase activities in Caulobacter crescentus.

    abstract::High-pressure liquid chromatography of a muramidase digest of murein sacculi from Caulobacter crescentus showed that the absence of D-alanine carboxypeptidase activity in the cells was reflected by a very high content of pentapeptide in the murein. Approximately half of the pentapeptide side chains were shown to conta...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.156.2.649-655.1983

    authors: Markiewicz Z,Glauner B,Schwarz U

    更新日期:1983-11-01 00:00:00

  • Essential role of flavohemoglobin in long-term anaerobic survival of Bacillus subtilis.

    abstract::A Bacillus subtilis culture incubated anaerobically in nitrate-containing medium lost viability during the first 3 days but recovered thereafter. A flavohemoglobin mutant showed very poor survival under these conditions unless the cells were prevented from carrying out nitrate respiration. ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.00557-06

    authors: Nakano MM

    更新日期:2006-09-01 00:00:00

  • Myxococcus xanthus does not respond chemotactically to moderate concentration gradients.

    abstract::Using a number of approaches we were unable to demonstrate a chemotactic response of Myxococcus xanthus to a variety of defined and complex materials. These data in addition to a number of prima facie arguments considerably reduce the likelihood that M. xanthus possesses a mechanism for chemotactic behavior. ...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.154.1.437-442.1983

    authors: Dworkin M,Eide D

    更新日期:1983-04-01 00:00:00

  • PATTERN OF SHEATH SYNTHESIS IN SPHAEROTILUS NATANS.

    abstract::Romano, Antonio H. (University of Cincinnati, Cincinnati, Ohio), and Dorothy J. Geason. Pattern of sheath synthesis in Sphaerotilus natans. J. Bacteriol. 88:1145-1150. 1964.-Formation of the characteristic sheath of Sphaerotilus natans was followed by immunofluorescence. Fluorescent antisheath antibody was obtained by...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.88.4.1145-1150.1964

    authors: ROMANO AH,GEASON DJ

    更新日期:1964-10-01 00:00:00

  • CcpA-independent regulation of expression of the Mg2+ -citrate transporter gene citM by arginine metabolism in Bacillus subtilis.

    abstract::Transcriptional regulation of the Mg(2+)-citrate transporter, CitM, the main citrate uptake system of Bacillus subtilis, was studied during growth in rich medium. Citrate in the growth medium was required for induction under all growth conditions. In Luria-Bertani medium containing citrate, citM expression was complet...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/jb.185.3.854-859.2003

    authors: Warner JB,Magni C,Lolkema JS

    更新日期:2003-02-01 00:00:00

  • Mu and IS1 transpositions exhibit strong orientation bias at the Escherichia coli bgl locus.

    abstract::The region upstream of the Escherichia coli bgl operon is an insertion hot spot for several transposons. Elements as distantly related as Tn1, Tn5, and phage Mu home in on this location. To see what characteristics result in a high-affinity site for transposition, we compared in vivo and in vitro Mu transposition patt...

    journal_title:Journal of bacteriology

    pub_type: 杂志文章

    doi:10.1128/JB.183.11.3328-3335.2001

    authors: Manna D,Wang X,Higgins NP

    更新日期:2001-06-01 00:00:00