Abstract：
:Complex I is one of the respiratory chain enzymes related to NADH dehydrogenase and is an encoded gene product derived from both nuclear and mitochondrial genomes. Transcription levels of ND1 (mitochondrial) and 51 kDa (nuclear) subunits of complex I in the postnatal development of the intrinsic muscle in rat tongues were determined by Northern blot analysis. Enzyme activity levels were determined by NADH staining with tetrazolum salt, and oxygen consumption of NADH-O2 oxidoreductase activity using a Clark-type electrode. The detailed structure of the mitochondria was observed using electron microscopy. The cross-sectional area of the mitochondria gradually increased during postnatal development, and the cristae also became complex, despite the length of mitochondria in muscle fibre being constant. The mitochondria density increased from birth to 15 days of age, and declined slightly afterwards. This pattern of density resembled that of NADH-O2 oxidoreductase activity. The level of mRNA for ND1 through Northern blot analysis gradually increased from birth to 15 days of age and was highest at 21 days. For 51 kDa, the level was highest at 0 days and fell thereafter to a constant low. This suggests that the production of NADH dehydrogenase is limited by 51 kDa of Complex I derived from nuclear genomes rather than by the increase in mitochondria and composition of muscle fibre types due to changes in feeding behaviour.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Fujita T,Sato Idoi
10.1046/j.1469-7580.2003.00152.xkeywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
205-12issue
2eissn
0021-8782issn
1469-7580journal_volume
202pub_type
杂志文章abstract：:Clinical research on the deposition of inhaled substances (e.g. inhaled medications, airborne contaminants, fumes) in the lungs necessitates anatomical models of the airways. Current conducting airway models lack three-dimensional (3D) reality as little information is available in the literature on the distribution of...
journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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更新日期：1995-08-01 00:00:00
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-06-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12590
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journal_title：Journal of anatomy
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doi：
更新日期：1991-12-01 00:00:00
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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doi：
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
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journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12063
更新日期：2014-01-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
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journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00160.x
更新日期：2003-03-01 00:00:00
