Abstract:
:Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3'-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Kops GJ,Burgering BMdoi
10.1046/j.1469-7580.2000.19740571.xkeywords:
subject
Has Abstractpub_date
2000-11-01 00:00:00pages
571-4eissn
0021-8782issn
1469-7580journal_volume
197 Pt 4pub_type
杂志文章,评审abstract::Axonal elements of the carotid baroreceptor zone of nine domestic fowls were examined with the electron microscope after either distal vagal ganglionectomy or midcervical vagotomy. The bare baroreceptor endings and the central axon of the encapsulated baroreceptor endings degenerated within 5 to 15 days after ganglion...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract::The effects of bacterial lipopolysaccharide (LPS) on the expression of surface antigens including major histocompatibility complex (MHC) and complement type 3 (CR3) receptors on microglial cells in the corpus callosum in postnatal rat brain were investigated. When LPS was injected intravenously (i.v.) in 1-d-old rats,...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::In most mammalian species the cardiac skeleton is composed of coarse collagen fibres, fibrocartilage, and pieces of hyaline cartilage. Bone, the os cordis, is a regular constituent of the ruminant heart. The cardiac skeleton of the otter (Lutra lutra) has not previously been described. The skeleton in 30 otter hearts ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.2000.19630485.x
更新日期:2000-04-01 00:00:00
abstract::The hooked element in the pes of turtles was historically identified by most palaeontologists and embryologists as a modified fifth metatarsal, and often used as evidence to unite turtles with other reptiles with a hooked element. Some recent embryological studies, however, revealed that this element might represent a...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/joa.12103
更新日期:2013-11-01 00:00:00
abstract::The kinematics of swings at joints can be described fully by means of two simple ratios and the angle at which the total operative force vector pulls upon a bone. The ratios can be applied to individual muscles, thus linking structural and functional myology in an exact way. The 'spurt' and 'shunt' types of muscle are...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::Both scanning (SEM) and transmission (TEM) electron microscopic studies of the major ductules and ducts of the perfused epididymal region of the drake were reported. The SEM correlated with TEM studies and confirmed some previous observations that the non-ciliated Types I and II cells in the proximal and distal effere...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-10-01 00:00:00
abstract::Due to conflicting data from previous studies a new methodological approach to evaluate heel pad stiffness and soft tissue deformation has been developed. The purpose of this study was to compare heel pad (HP) stiffness in both limbs between males and females during a dynamic unloading and loading activity. Ten males ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13207
更新日期:2020-09-01 00:00:00
abstract::The absolute density of the right and left os calcis has been measured in a group of healthy, sedentary volunteers. There was a significant difference between the density of the right and left os calcis in 90% of the subjects. Statistically, when all of the subjects were considered, the side on which the os calcis was...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract::The sensory and motor innervation of a sample of 202 muscle spindles from the dorsolateral tail muscles of eight cats were studied by silver and gold staining techniques. The range of diameters of Group Ia afferent nerve fibres to primary (P) sensory endings was 2.0-14.0 micron with a peak at 8.5 micron. The range of ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::The volume and shape (the axial ratio:length/diameter) of mitochondria in periportal and perihepatic hepatocytes from newborn, 5 days old, 10 days old and adult male ddY mice were analysed by quantitative electron microscopy. In newborn animals, the volume and relative histogram of the axial ratio were not significant...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::Large perforations of the tympanic membrane were made in groups of guinea-pigs. The mitotic response in the stratified squamous epithelium at the edge of the wound was examined in perforations between 1 and 28 days after injury. Peaks of activity were discovered at 2, 15-16 and 24 days after wounding. It was also foun...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::We investigated the occurrence and anatomy of the vomeronasal system (VNS) in tadpoles of 13 different anuran species. All of the species possessed a morphologically fully developed VNS with a highly conserved anatomical organisation. We found that a bean-shaped vomeronasal organ (VNO) developed early in the tadpoles,...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2012.01543.x
更新日期:2012-10-01 00:00:00
abstract::Small clusters of extra large muscle fibres were identified in hindlimb muscles of neonatal mice (strain C57BL/10ScSn). At two days of age they had a significantly greater cross-sectional area than their normal counterparts (P less than 0.01). Fibre typing methods (NADH-tetrazolium reductase, ATPase and phosphorylase)...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::This review begins by setting out the context and the scope of human evolution. Several classes of evidence, morphological, molecular, and genetic, support a particularly close relationship between modern humans and the species within the genus Pan, the chimpanzee. Thus human evolution is the study of the lineage, or ...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1046/j.1469-7580.2000.19710019.x
更新日期:2000-07-01 00:00:00
abstract::Alpha (greater than 40 microns) and gamma (less than 30 microns) motoneurons in inspiratory motor nuclei of the thoracic spinal cord of the adult cat were labelled retrogradely by the intramuscular injection of HRP. Small (less than 30 microns) unlabelled neurons within 200-300 microns of labelled motoneurons were ana...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::Ultrasound of the calcaneus may be used as a cheap, ionising radiation-free and easy to use indicator of skeletal status, and hence of osteoporotic fracture risk. At present ultrasound is not widely used as it suffers from high precision errors. As ultrasound parameters are determined in part by bone mineral density (...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1998.19330449.x
更新日期:1998-10-01 00:00:00
abstract::Proximal femoral morphology and associated musculature are of special relevance to the understanding of hominoid locomotor systems. Knowledge of bone-muscle correspondence in extant hominoids forms an important comparative basis for inferring structure-function relationships in fossil hominids. However, there is still...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12270
更新日期:2015-03-01 00:00:00
abstract::Current surgical treatments for degenerative intervertebral disc disease do not restore full normal spinal movement. Tissue engineering a functional disc replacement may be one way to circumvent this limitation, but will require an integration of the different tissues making up the disc for this approach to be success...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2012.01537.x
更新日期:2012-12-01 00:00:00
abstract::The present study investigated, by immunohistochemistry, the postnatal occurrence and anatomical localisation of some bone and cartilage proteins and proteoglycans in the rat coronal sutural region. Thirty two Sprague-Dawley rats, four in each group, were killed at ages 3, 5, 8, 10, 15, 30, 50 and 100 days and the sut...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1990-12-01 00:00:00
abstract::The mitotic response to wounding was examined in ulcers resulting from the excision of small pieces of rectal mucous membrane in two groups of guinea-pigs. One group was wounded at 09.00 hours and a second group at 21.00 hours. Mitotic counts were carried out in the glandular epithelium at the ulcer edges at 2 hourly ...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract::A new type of magnetic resonance imaging analysis, based on fusion of three-dimensional reconstructions of time-to-peak parametric maps and high-resolution T1-weighted images, is proposed in order to evaluate the perfusion of selected volumes of interest. Because in recent years a wealth of data have suggested the cru...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2006.00659.x
更新日期:2007-01-01 00:00:00
abstract::In zoology it is well known that birds are characterized by the presence of feathers, and mammals by hairs. Another common point of view is that avian scales are directly related to reptilian scales. As a skin embryologist, I have been fascinated by the problem of regionalization of skin appendages in amniotes through...
journal_title:Journal of anatomy
pub_type: 杂志文章,评审
doi:10.1111/j.1469-7580.2008.01041.x
更新日期:2009-04-01 00:00:00
abstract::The effects of chronic neuromuscular inactivity on the phenotype and size of muscle fibres in a fast ankle extensor (medial gastrocnemius, MG) and a fast ankle flexor (tibialis anterior, TA) muscle of the rat hindlimb were determined. Inactivity was produced by spinal cord isolation (SI), i.e. complete spinal cord tra...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/j.1469-7580.2006.00665.x
更新日期:2007-01-01 00:00:00
abstract::We present a simple and quick system for accurately scoring the developmental progress of mouse embryos harvested on embryonic day 14 (E14.5). Based solely on the external appearance of the maturing forelimb, we provide a convenient way to distinguish six developmental sub-stages. Using a variety of objective morphome...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12590
更新日期:2017-05-01 00:00:00
abstract::It is unknown whether loading of the lower limbs through additional storage of fat mass as evident in obesity would promote muscular adaptations similar to those seen with resistance exercise. It is also unclear whether ageing modulates any such adjustments. This study aimed to examine the relationships between adipos...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.12248
更新日期:2014-12-01 00:00:00
abstract::The distribution of mRNAs and antigens of tissue type (t) and urokinase type (u) plasminogen activators (PA) plus their corresponding inhibitors, type-1 (PAI-1) and type-2 (PAI-2) were studied in human and rhesus monkey placentae by in situ hybridisation and immunocytochemistry. Specific monkey cRNA and antibodies aga...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1046/j.1469-7580.1999.19420183.x
更新日期:1999-02-01 00:00:00
abstract::The fine structure of the intercellular junctions of the hen parathyroid gland was studied using freeze-fracture replicas and thin sections. In the conventional thin sections, desmosomes, intermediate junctions (maculae adherentes) and gap junctions were observed, and in the lanthanum-fixed sections, tight junctions (...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
abstract::Distinguishing arteries from veins in vivo has a great significance in clinical practices and preclinical studies. Optical imaging methods such as two-photon microscopy can provide high-resolution morphological information of tissue and are therefore extremely suitable for imaging small blood vessels. However, few opt...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:10.1111/joa.13080
更新日期:2020-01-01 00:00:00
abstract::Glycosaminoglycans have been demonstrated throughout the cutaneous BMZ at the ultrastructural level. Colloidal iron and cationised ferritin proved of limited value, whilst staining with Alcian blue and application of the critical electrolyte concentration principle has provided evidence for the presence of sulphated G...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::The ultrastructure of the basal lamina of histologically normal human breast tissue was determined in 19 women undergoing operations for removal of a fibroadenoma or reduction mammoplasty. The day of the menstrual cycle was determined by hormone assay and direct questioning. Previously documented ultrastructural appea...
journal_title:Journal of anatomy
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00