Forkhead transcription factors are targets of signalling by the proto-oncogene PKB (C-AKT).

Abstract:

:Following the discovery that the proto-oncogene protein kinase B (PKB) functions as a downstream element in signalling from phosphoinositide 3'-kinase (PI3-kinase) (Burgering & Coffer, 1995), PKB has been shown to mediate a diverse array of PI3-kinase dependent cellular responses. Most recently PKB-dependent phosphorylation of 3 members of the family of Forkhead transcription factors has been demonstrated to play a role in PI3-kinase dependent effects on transcription. This review focuses on this newly discovered function of PKB in conveying the diversity of PI3-kinase dependent cellular responses.

journal_name

J Anat

journal_title

Journal of anatomy

authors

Kops GJ,Burgering BM

doi

10.1046/j.1469-7580.2000.19740571.x

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

571-4

eissn

0021-8782

issn

1469-7580

journal_volume

197 Pt 4

pub_type

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