Intradermal infection model for pathogenesis and vaccine studies of murine visceral leishmaniasis.

abstract：:Complement receptor type 3 (CR3) was initially described as an opsonic receptor. Subsequently, CR3-mediated lectin-sugar recognition mechanisms have been shown to play a major role in the nonopsonic phagocytosis of several pathogens, among them Mycobacterium tuberculosis. Little is known about the binding and signal t...

journal_title：Infection and immunity

authors： Le Cabec V,Cols C,Maridonneau-Parini I

更新日期：2000-08-01 00:00:00

abstract：:A 75-kilodalton major protein (75K protein) was purified to homogeneity from the cell lysate fraction and the envelope of Bacteroides gingivalis 381. The 75K protein was originally present in the outer membrane or the outermost part of this organism as a large, stable complex with an apparent molecular weight of about...

journal_title：Infection and immunity

authors： Yoshimura F,Watanabe K,Takasawa T,Kawanami M,Kato H

更新日期：1989-11-01 00:00:00

abstract：:Organisms of the Mycobacterium avium complex are associated with disseminated infection in patients with AIDS. The mechanisms that account for the survival of the intracellular bacteria are unknown. We document here that infection of C57BL/6 black mice with M. avium 101 triggered interleukin-10 (IL-10) production. The...

journal_title：Infection and immunity

authors： Bermudez LE,Champsi J

更新日期：1993-07-01 00:00:00

abstract：:The effect of human-specific antibody on surface membrane antigens of trypomastigotes of Trypanosoma cruzi was studied in vitro by using immunofluorescence methods. Immune sera induced aggregation of surface antigens in trypomastigotes to form polar cell caps. ...

journal_title：Infection and immunity

authors： Schmuñis GA,Szarfman A,Langembach T,de Souza W

更新日期：1978-05-01 00:00:00

abstract：:Iron is limiting in the human host, and bacterial pathogens respond to this environment by regulating gene expression through the ferric uptake regulator protein (Fur). In vitro studies have demonstrated that Neisseria gonorrhoeae controls the expression of several critical genes through an iron- and Fur-mediated mech...

journal_title：Infection and immunity

authors： Agarwal S,King CA,Klein EK,Soper DE,Rice PA,Wetzler LM,Genco CA

更新日期：2005-07-01 00:00:00

abstract：:To characterize the mechanism by which interleukin 10 (IL-10) inhibits Th1 responses to intracellular pathogens, we evaluated the interaction between IL-10 and Mycobacterium tuberculosis-induced gamma interferon (IFN-gamma) production by peripheral blood mononuclear cells from persons across the spectrum of tuberculou...

journal_title：Infection and immunity

authors： Gong JH,Zhang M,Modlin RL,Linsley PS,Iyer D,Lin Y,Barnes PF

更新日期：1996-03-01 00:00:00

abstract：:Moraxella catarrhalis expresses surface receptor proteins that specifically bind host transferrin (Tf) and lactoferrin (Lf) in the first step of the iron acquisition pathway. Acute- and convalescent-phase antisera from a series of patients with M. catarrhalis pulmonary infections were tested against Tf and Lf receptor...

journal_title：Infection and immunity

authors： Yu RH,Bonnah RA,Ainsworth S,Schryvers AB

更新日期：1999-08-01 00:00:00

abstract：:A Mycoplasma pneumoniae cytadhesin P1 gene with novel nucleotide sequence variation has been identified. Four clinical strains of M. pneumoniae were found to carry this type of P1 gene. This new P1 gene is similar to the known group II P1 genes but possesses novel sequence variation of approximately 300 bp in the RepM...

journal_title：Infection and immunity

authors： Kenri T,Taniguchi R,Sasaki Y,Okazaki N,Narita M,Izumikawa K,Umetsu M,Sasaki T

更新日期：1999-09-01 00:00:00

abstract：:We have cloned and sequenced the d15 gene from two strains of Haemophilus influenzae type b (Hib) and two strains of nontypeable H. influenzae (NTHI). The nucleotide and deduced protein sequences of d15 are highly conserved, with only a small variable region identified near the carboxyl terminus of the protein. Analys...

journal_title：Infection and immunity

authors： Loosmore SM,Yang YP,Coleman DC,Shortreed JM,England DM,Klein MH

更新日期：1997-09-01 00:00:00

abstract：:Strains of Cryptococcus neoformans vary in resistance to phagocytosis in vitro. The binding of isolated capsular polysaccharide (CPS) to a capsule-free mutant of C. neoformans confers resistance to phagocytosis. The importance of capsule composition to differences among strains in susceptibility to phagocytosis was ev...

journal_title：Infection and immunity

authors： Small JM,Mitchell TG

更新日期：1989-12-01 00:00:00

abstract：:A purified human granulocyte colony-stimulating factor (hG-CSF) was studied for its protective effect on the induction of neutropenia and enhanced susceptibility to microbial infections in mice receiving cyclophosphamide (CPA). A severe reduction in peripheral blood neutrophils was induced 4 days after injection with ...

journal_title：Infection and immunity

authors： Matsumoto M,Matsubara S,Matsuno T,Tamura M,Hattori K,Nomura H,Ono M,Yokota T

更新日期：1987-11-01 00:00:00

abstract：:Clostridium difficile causes pseudomembranous colitis through the action of Rho-modifying proteins, toxins A and B. Antibodies directed against C. difficile toxin A prevent or limit C. difficile-induced colitis. We engineered plasmid pETR14, containing the hlyB and hlyD genes of the Escherichia coli hemolysin operon, ...

journal_title：Infection and immunity

authors： Ryan ET,Butterton JR,Smith RN,Carroll PA,Crean TI,Calderwood SB

更新日期：1997-07-01 00:00:00

abstract：:Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches. ...

journal_title：Infection and immunity

authors： Huang Y,Liang W,Pan A,Zhou Z,Huang C,Chen J,Zhang D

更新日期：2003-09-01 00:00:00

abstract：:To study the specific role of transmembrane tumor necrosis factor (tmTNF) in protective and pathological responses against the gastrointestinal helminth Trichinella spiralis, we compared the immune responses of TNF-alpha/lymphotoxin alpha (LTalpha)(-/-) mice expressing noncleavable transgenic tmTNF to those of TNF-alp...

journal_title：Infection and immunity

authors： Ierna MX,Scales HE,Mueller C,Lawrence CE

更新日期：2009-09-01 00:00:00

abstract：:Evidence is presented to indicate that Plasmodium berghei merozoites, but not trophozotites, have an antiphagocytic capsule. The capsule appears to form around the developing merozoties of the schizont in the parasitophorous vacuole. Serum from animals immune to P. berghei reacts with this capsule. After reaction with...

journal_title：Infection and immunity

authors： Brooks C,Kreier JP

更新日期：1978-06-01 00:00:00

abstract：:Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI) gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We characterized the functional role of the gonococcal MetQ protein, which is the methionine binding component of an ABC transporter system, and as...

journal_title：Infection and immunity

authors： Semchenko EA,Day CJ,Seib KL

更新日期：2017-01-26 00:00:00

abstract：:Because combined administration of intramuscular and intravenous interferon has been partially successful in the incubationary treatment of rabies, the effect of direct interferon administration into the cerebrospinal fluid space was tested. After injecting 1,800 U of interferon into the cisterna magna or the lateral ...

journal_title：Infection and immunity

authors： Ho M,Nash C,Morgan CW,Armstrong JA,Carroll RG,Postic B

更新日期：1974-02-01 00:00:00

abstract：:An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of...

journal_title：Infection and immunity

authors： D'Avila H,Almeida PE,Roque NR,Castro-Faria-Neto HC,Bozza PT

更新日期：2007-03-01 00:00:00

abstract：:Studies were performed to determine the optimal sites for primary isolation of Mycoplasma pulmonis from the respiratory system of laboratory rats. In a preliminary study, a group of 42 rats was cultured for respiratory M. pulmonis at several sites. Tracheal washes yielded the highest number of positive cultures (61.9%...

journal_title：Infection and immunity

authors： Lentsch RH,Wagner JE,Owens DR

更新日期：1979-11-01 00:00:00

abstract：:The structural gene of pneumolysin was randomly mutagenized. A screen, developed to identify mutants with reduced hemolytic activity, identified substitutions within the cysteine-containing region and also at residues toward the N terminus of the toxin. These are the first reported changes within the N-terminal region...

journal_title：Infection and immunity

authors： Hill J,Andrew PW,Mitchell TJ

更新日期：1994-02-01 00:00:00

abstract：:A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a multicomponent, multistage DNA vaccine for the simian malaria species Plasmodium knowlesi including two preerythrocytic...

journal_title：Infection and immunity

authors： Rogers WO,Baird JK,Kumar A,Tine JA,Weiss W,Aguiar JC,Gowda K,Gwadz R,Kumar S,Gold M,Hoffman SL

更新日期：2001-09-01 00:00:00

abstract：:Lipopolysaccharide (LPS) from three human and four monkey isolates of Campylobacter jejuni was extracted in high yields that revealed ladder-like structures in polyacrylamide gels by direct silver staining. These observations demonstrate that C. jejuni possesses LPS with O-chain repeating units typical of the family E...

journal_title：Infection and immunity

authors： Blake DC Jr,Russell RG

更新日期：1993-12-01 00:00:00

abstract：:The antihistoplasma activity of recombinant murine gamma interferon (rMuIFN-gamma)-treated macrophages of the RAW 264.7 cell line depends on the generation of nitric oxide (NO.) from L-arginine. Macrophages of the P388D1 cell line treated with rMuIFN-gamma do not produce NO. or inhibit the intracellular growth of Hist...

journal_title：Infection and immunity

authors： Lane TE,Otero GC,Wu-Hsieh BA,Howard DH

更新日期：1994-04-01 00:00:00

abstract：:Pathogen attachment to host cells is a key process during infection, and inhibition of pathogen adhesion is a promising approach to the prevention of infectious disease. We have previously shown that multivalent adhesion molecules (MAMs) are abundant in both pathogenic and commensal bacterial species, mediate early at...

journal_title：Infection and immunity

authors： Al-Saedi F,Stones DH,Vaz DP,Krachler AM

更新日期：2016-05-24 00:00:00

abstract：:Chlamydia trachomatis serovar L2 is an obligate intracellular bacterium which is internalized in target epithelial cells by endocytosis and resides within a membrane-bound vesicle. Over the next several hours following entry, individual serovar L2-containing vesicles fuse with one another to form a single membrane-bou...

journal_title：Infection and immunity

authors： Schramm N,Bagnell CR,Wyrick PB

更新日期：1996-04-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) glycoprotein gC was purified by affinity chromatography with an immunosorbent column containing monoclonal antibody to HSV-1 gC, and its reactivity with rabbit antisera was measured by enzyme-linked immunosorbent assay and sodium dodecyl sulfate-polyacrylamide gel electrophoretic an...

journal_title：Infection and immunity

authors： Zweig M,Heilman CJ Jr,Bladen SV,Showalter SD,Hampar B

更新日期：1983-08-01 00:00:00

abstract：:Restoration of the ability of hypogammaglobulinemic serum to support opsonophagocytosis and intracellular killing of Bacteroides fragilis and Bacteroides thetaiotaomicron by human polymorphonuclear leukocytes was achieved by supplementation with normal human immunoglobulin M, but not with normal human immunoglobulin G...

journal_title：Infection and immunity

authors： Bjornson AB,Bjornson HS,Kitko BP

更新日期：1980-05-01 00:00:00

abstract：:Recent studies have shown that children with blood group A have increased susceptibility to enterotoxigenic Escherichia coli (ETEC) diarrhea and that Lewis blood group "a" antigen (Le(a)) may be a candidate receptor for ETEC colonization factor (CF) antigen I (CFA/I) fimbriae. Based on these findings, we have attempte...

journal_title：Infection and immunity

authors： Ahmed T,Lundgren A,Arifuzzaman M,Qadri F,Teneberg S,Svennerholm AM

更新日期：2009-05-01 00:00:00

abstract：:Deoxyribonucleic acid (DNA) base composition, as measured by guanine plus cytosine (G + C) content, was determined in 17 strains of Sporothrix schenckii and Ceratocystis species. The average G + C content for S. schenckii was 54.7 +/- 0.2 mol%. No strain of Ceratocystis, with the exception of C. minor, gave values for...

journal_title：Infection and immunity

authors： Mendonça-Hagler LC,Travassos LR,Lloyd KO,Phaff HJ

更新日期：1974-05-01 00:00:00

abstract：:Lung dendritic cells were identified by immunohistochemistry in lung tissue sections from C57BL/6 mice. Following isolation from the lungs using CD11c magnetic beads, the flow cytometric analysis of I-A(b+) and CD11c(+) cells indicated a mixed population of dendritic cells at different stages of maturation, with most ...

journal_title：Infection and immunity

authors： Gonzalez-Juarrero M,Orme IM

更新日期：2001-02-01 00:00:00