Abstract:
:Evidence is presented to indicate that Plasmodium berghei merozoites, but not trophozotites, have an antiphagocytic capsule. The capsule appears to form around the developing merozoties of the schizont in the parasitophorous vacuole. Serum from animals immune to P. berghei reacts with this capsule. After reaction with immune serum, the antiphagocytic action of the capsule is lost. By the process of binding serum protein, the capsule becomes electron dense and can be readily visuallzed as the surface coat by electron microscopy. At physiological temperatures, phagocytosis by macrophages rapidly follows adhesion of antibody-coated parasites. Both tight and loose phagosomes are formed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Brooks C,Kreier JPdoi
10.1128/IAI.20.3.827-835.1978subject
Has Abstractpub_date
1978-06-01 00:00:00pages
827-35issue
3eissn
0019-9567issn
1098-5522journal_volume
20pub_type
杂志文章abstract::Classical and El Tor strains of Vibrio cholerae were examined for production of bacteriophage or bacteriophage-related material by electron microscopy of mitomycin C-induced cultures. The strains were also tested for pathogenicity by using the ligated ileal loops of adult rabbits. Of the 27 strains tested, 25 showed a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.1.4.417-420.1970
更新日期:1970-04-01 00:00:00
abstract::A major obstacle to studying the functions of particular gene products in the mouse-tick infectious cycle of Borrelia burgdorferi has been an inability to knock out genes in pathogenic strains. Here, we investigated conditions for site-directed mutagenesis in B31 MI, the low-passage-number, infectious B. burgdorferi s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.4.2139-2150.2002
更新日期:2002-04-01 00:00:00
abstract::Previously we demonstrated that recombinant murine interleukin-12 (rmIL-12) administration can promote a primary Th1 response while suppressing the Th2 response in mice primed with 2,4, 6-trinitrophenyl-keyhole limpet hemocyanin (TNP-KLH). The present studies examined the capacity of rmIL-12 to drive a Th1 response to...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2166-2171.1999
更新日期:1999-05-01 00:00:00
abstract::Passive protection, the administration of antibodies to prevent infection, has garnered significant interest in recent years as a potential prophylactic countermeasure to decrease the prevalence of hospital-acquired infections. Pili, polymerized protein structures covalently anchored to the peptidoglycan wall of many ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01403-13
更新日期:2014-04-01 00:00:00
abstract::The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vaccines and immunodiagnostic tests for tuberculosis (TB). Gene pai...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05344-11
更新日期:2011-10-01 00:00:00
abstract::Tubercle bacilli failed to grow in iron-void media enriched with solutions of iron-containing transferrin (Tr) or ferritin (F) because these substances do not provide the bacilli with iron, which is essential for their growth. Animal serum and macrophages possessed no iron carrier with an ability to satisfy the need o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.1.34-40.1974
更新日期:1974-01-01 00:00:00
abstract::Despite the widely held belief that gastric acid serves as a barrier to bacterial pathogens, there are almost no experimental data to support this hypothesis. We have developed a mouse model to quantify the effectiveness of gastric acid in mediating resistance to infection with ingested bacteria. Mice that were consti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01138-07
更新日期:2008-02-01 00:00:00
abstract::During the recent bioterrorism-related outbreaks, inhalational anthrax had a 45% mortality in spite of appropriate antimicrobial therapy, underscoring the need for better adjuvant therapies. The variable latency between exposure and development of disease suggests an important role for the host's innate immune respons...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.3.1291-1297.2004
更新日期:2004-03-01 00:00:00
abstract::Enterococcus faecalis is a highly stress resistant opportunistic pathogen. The intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. We show in this work that general resistance to very different en...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01299-12
更新日期:2013-08-01 00:00:00
abstract::As an opportunistic bacterial pathogen, Pseudomonas aeruginosa mainly affects immunocompromised individuals as well as patients with cystic fibrosis. In a previous study, we showed that ExoS of P. aeruginosa, when injected into host cells through a type III secretion apparatus, functions as an effector molecule to tri...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.6.3361-3370.2003
更新日期:2003-06-01 00:00:00
abstract::Rhodococcus equi is an intracellular pathogen which causes pneumonia in young horses and in immunocompromised humans. R. equi arrests phagosome maturation in macrophages at a prephagolysosome stage and grows inside a privileged compartment. Here, we show that, in murine macrophages activated with gamma interferon and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00983-10
更新日期:2011-05-01 00:00:00
abstract::Guinea pig peritoneal or alveolar macrophages were inoculated with Mycoplasma pneumoniae cells. Extracellular mycoplasms were killed by complement treatment, and the effect of macrophage action on the number of the remaining viable mycoplasmas was observed. The complement killing was to some extent inhibited by the pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.11-15.1979
更新日期:1979-07-01 00:00:00
abstract::The cell surface hydrophobicity of 10 pigmented and 4 nonpigmented clinical Serratia marcescens strains was studied, based on the ability of the strains to adhere to hydrocarbons and to polystyrene. The cell surface hydrophobicity depended greatly on growth temperature; all of the strains tested were adherent followin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.51.3.932-935.1986
更新日期:1986-03-01 00:00:00
abstract::It was demonstrated that complement-coated sheep erythrocytes bind to Candida albicans cells grown in serum-free RPMI 1640 medium. Testing of purified complement components proved that iC3b and C3d were responsible for the reaction, whereas C3b and C3b-H reacted only slightly if at all. Binding occurred only to C. alb...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.2.598-600.1985
更新日期:1985-11-01 00:00:00
abstract::Mouse spleen cultures were infected with murine cytomegalovirus, either before or after separating the cells into various classes, and the growth of virus and production of infectious centers were measured in each cell class. The separation techniques, which were used in various combinations, comprised: adherence to p...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.3.853-860.1979
更新日期:1979-12-01 00:00:00
abstract::It was found that cells of Nocardia asteroides GUH-2 (virulent) were approximately 10 times more virulent than cells of N. asteroides 14759 (intermediate) and greater that 500 times more virulent than N. asteroides 10905 (avirulent) cells when early-stationary-phase cultures suspended in saline were injected intraven...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.16.3.995-1004.1977
更新日期:1977-06-01 00:00:00
abstract::To study responses to Mycobacterium leprae antigens, we developed an in vitro model system in which latex particles coated with M. leprae sonic extract (MLSON) antigen were presented to monocytes. Uptake and oxidative response as measured by superoxide production to these antigens were investigated. Phagocytosis of ML...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.9.3724-3729.1993
更新日期:1993-09-01 00:00:00
abstract::The ocular surface is continuously exposed to potential pathogens, including free-living amoebae. Acanthamoeba species are among the most ubiquitous amoebae, yet Acanthamoeba keratitis is remarkably rare. The pathogenesis of Acanthamoeba keratitis is a complex, sequential process. Here we show that Acanthamoeba kerati...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.2.1061-1068.2005
更新日期:2005-02-01 00:00:00
abstract::Henle 407 and HeLa cells were compared as hosts for Shigella dysenteriae at a low multiplicity of infection. Efficiency of attachment and invasion without centrifugation, as well as selectivity for pathogenic over nonpathogenic S. dysenteriae without Congo red, were much greater for Henle 407 cells than for HeLa cells...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.7.2401-2403.1990
更新日期:1990-07-01 00:00:00
abstract::Phenethyl alcohol, at the maximum concentration which did not inhibit growth (0.3% [vol/vol]), inhibited the production of alpha-lysin and exoproteases but not that of delta-lysin in Staphylococcus aureus Wood 46. The inhibition of alpha-lysin was reversible, and transient accumulation of cell-associated alpha-lysin o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.112-117.1985
更新日期:1985-01-01 00:00:00
abstract::Mesocricetus auratus (golden hamsters) infected with leishmania developed characteristic B cell immune responses that depended on the infecting species of leishmania. Thus, hamsters infected with viscerotropic leishmania (Leishmania donovani) developed antileishmania antibodies and hypergammaglobulinemia due to polycl...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.3.871-876.1982
更新日期:1982-12-01 00:00:00
abstract::In vivo- and in vitro-grown Mycoplasma hyopneumoniae organisms were inoculated onto newborn piglet tracheal organ cultures to provide a model for interaction of this organism with ciliated respiratory epithelium. Ciliostasis and loss of cilia in tracheal rings were induced by M. hyopneumoniae grown in vivo and with lo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.12.5312-5318.1994
更新日期:1994-12-01 00:00:00
abstract::Brazilian purpuric fever (BPF)-associated Haemophilus influenzae biogroup aegyptius strain F3031 contains two identical copies of a five gene cluster (hifA to hifE) encoding pili similar to well-characterized Hif fimbriae of H. influenzae type b. HifE, the putative pilus tip adhesin of F3031, shares only 40% amino aci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.4.1622-1631.1998
更新日期:1998-04-01 00:00:00
abstract::Synthetic oligosaccharides derived from the capsular polysaccharide (PRP) of Haemophilus influenzae type b were conjugated to carrier proteins via a thioether linkage. Conjugates were made of trimeric and tetrameric ribose-ribitol-phosphate and tetanus toxoid or diphtheria toxin. All conjugates elicited anti-PRP antib...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.5.1826-1833.1992
更新日期:1992-05-01 00:00:00
abstract::Four glycoproteins of Treponema pallidum were identified by intrinsic [14C]glucosamine labeling. Only two glycoproteins were demonstrated in T. phagedenis biotype Reiter with the same technique. Glycoproteins of both treponemes were characterized as antigens and shown to be localized within the outer membranes of the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.3.867-869.1984
更新日期:1984-12-01 00:00:00
abstract::Neisseria meningitidis is a human-specific pathogen and leading cause of meningitis and septicemia. Factor H binding protein (fHbp), a virulence factor which protects N. meningitidis from innate immunity by binding the human complement regulator factor H (fH) with high affinity, is also a key antigen in vaccines being...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01183-13
更新日期:2014-03-01 00:00:00
abstract::A superoxide dismutase (SOD) gene from the obligate intracellular bacterium Coxiella burnetii has been cloned, and its DNA sequence has been determined and expressed in Escherichia coli. The gene was identified on pSJR50, a pHC79-derived genomic clone, by using the polymerase chain reaction with degenerate oligonucleo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.9.3814-3823.1992
更新日期:1992-09-01 00:00:00
abstract::Mice were infected with 170 Trichinella spiralis larvae, and their blood clearance of carbon particles was studied 4, 7, 13, 32, and 135 days later and compared with that of noninfected control mice. Clearance in mice with a 4-day-old infection was comparable to that in the controls; clearances in mice with 7- and 13-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-12-01 00:00:00
abstract::Purified Escherichia coli type 1 fimbriae have been shown previously to stimulate T-cell-independent proliferation of human B lymphocytes. The response is mediated by the mannose-specific, lectin-like adhesin protein FimH. Here we show that type 1 fimbriae also stimulate immunoglobulin (Ig) secretion by B cells. The r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.12.5197-5203.1992
更新日期:1992-12-01 00:00:00
abstract::Acute pyelonephritis, a complication of Escherichia coli bacteriuria, must represent a bacterial invasion through the kidney epithelium. To study this process, we overlaid bacterial suspensions onto monolayers of cultured human kidney proximal tubular epithelial cells and measured cytotoxicity by release of lactate de...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.5.1281-1289.1990
更新日期:1990-05-01 00:00:00