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Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.

Abstract：

:Antigen receptor gene assembly is regulated by transcriptional promoters and enhancers, which control the accessibility of gene segments to a lymphocyte-specific V(D)J recombinase. However, it remained unclear whether accessibility depends on the process of transcription itself or chromatin modifications that accompany transcription. By using T cell receptor beta substrates that integrate stably into nuclear chromatin, we show that promoter location, rather than germ-line transcription or histone acetylation, is a primary determinant of recombination efficiency. These spatial constraints on promoter positioning may reflect an RNA polymerase-independent mechanism to target adjacent gene segments for chromatin remodeling events that facilitate rearrangement.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Sikes ML,Meade A,Tripathi R,Krangel MS,Oltz EM

doi

10.1073/pnas.182166699

keywords:

subject

Has Abstract

pub_date

2002-09-17 00:00:00

pages

12309-14

issue

19

eissn

0027-8424

issn

1091-6490

pii

182166699

journal_volume

99

pub_type

杂志文章

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