Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair.

abstract：:We demonstrate that poly(dA-dT) can adopt two conformations in solution, with the relative proportions dependent on the nature and concentration of the counter ion and cationic ligands. The synthetic DNA exhibits a dinucleotide repeat conformation on addition of CsF and Me4NCl at molar concentrations, with the NMR spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Kozlowski SA,Suggs JW,Cox SD

更新日期：1981-07-01 00:00:00

abstract：:S-nitrosylation, the selective modification of cysteine residues in proteins to form S-nitrosocysteine, is a major emerging mechanism by which nitric oxide acts as a signaling molecule. Even though nitric oxide is intimately involved in the regulation of vascular smooth muscle cell functions, the potential protein tar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greco TM,Hodara R,Parastatidis I,Heijnen HF,Dennehy MK,Liebler DC,Ischiropoulos H

更新日期：2006-05-09 00:00:00

abstract：:Cell-mediated immunity is critical for host resistance to tuberculosis. T lymphocytes recognizing antigens presented by the major histocompatibility complex (MHC) class I and class II molecules have been found to be necessary for control of mycobacterial infection. Mice genetically deficient in the generation of MHC c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teitelbaum R,Cammer M,Maitland ML,Freitag NE,Condeelis J,Bloom BR

更新日期：1999-12-21 00:00:00

abstract：:The induction of antigen-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune tolerance. In addition to their classical role as sentinels of the immune response-inducing T cell reactivity, dendritic cells (DCs) play an important role in maintaining peripheral tolerance through th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chorny A,Gonzalez-Rey E,Fernandez-Martin A,Pozo D,Ganea D,Delgado M

更新日期：2005-09-20 00:00:00

abstract：:Erythropoietin, the hormone that is the primary regulator of erythrocyte production, has been purified from anemic-sheep plasma, with a purification factor of more than 1 million. Gel electrophoresis shows that the major contaminant is desialated erythropoietin. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldwasser E,Kung CK

更新日期：1971-04-01 00:00:00

abstract：:The land plants and their immediate green algal ancestors, the charophytes, form the Streptophyta. There is evidence that both the chloroplast DNA (cpDNA) and mitochondrial DNA (mtDNA) underwent substantial changes in their architecture (intron insertions, gene losses, scrambling in gene order, and genome expansion in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turmel M,Otis C,Lemieux C

更新日期：2002-08-20 00:00:00

abstract：:A number of studies have noted that nucleotide substitution rates at the chloroplast-encoded rbcL locus violate the molecular clock principle. Substitution rate variation at this plastid gene is particularly pronounced between palms and grasses; for example, a previous study estimated that substitution rates in rbcL s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaut BS,Morton BR,McCaig BC,Clegg MT

更新日期：1996-09-17 00:00:00

abstract：:Paired immunoglobulin-like type 2 receptor α (PILRα) and β (PILRβ) belong to the PILR family and are related to innate immune regulation in various species. Despite their high sequence identity, PILRα and PILRβ are shown to have variant sialic acid (SA) binding avidities. To explore the molecular basis of this interac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu Q,Lu G,Qi J,Wang H,Xuan Y,Wang Q,Li Y,Zhang Y,Zheng C,Fan Z,Yan J,Gao GF

更新日期：2014-06-03 00:00:00

abstract：:Examples of finite-dimensional Hopf algebras over a field, whose antipodes have arbitrary even orders >/=4 as mappings, are furnished. The dimension of the Hopf algebra is q(n+1), where the antipode has order 2q, q >/= 2, and n is an arbitrary positive integer. The algebras are not semisimple, and neither they nor the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taft EJ

更新日期：1971-11-01 00:00:00

abstract：:The world's oceans are undergoing profound changes as a result of human activities. However, the consequences of escalating human impacts on marine mammal biodiversity remain poorly understood. The International Union for the Conservation of Nature (IUCN) identifies 25% of marine mammals as at risk of extinction, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davidson AD,Boyer AG,Kim H,Pompa-Mansilla S,Hamilton MJ,Costa DP,Ceballos G,Brown JH

更新日期：2012-02-28 00:00:00

abstract：:Members of the LEF-1/TCF family of transcription factors have been implicated in mediating a nuclear response to Wnt signals by association with beta-catenin. Consistent with this view, mice carrying mutations in either the Wnt3a gene or in both transcription factor genes Lef1 and Tcf1 were previously found to show a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galceran J,Hsu SC,Grosschedl R

更新日期：2001-07-17 00:00:00

abstract：:Adrenal chromaffin granules contain at least 10 peptides, ranging in size from 3 to 5 kilodaltons, that yield, upon digestion with trypsin, peptides that show specific binding to opiate receptors. All are distinctly different from beta-endorphin. Two of these peptides have been purified to homogeneity and subjected to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kimura S,Lewis RV,Stern AS,Rossier J,Stein S,Udenfriend S

更新日期：1980-03-01 00:00:00

abstract：:The formation of complex but highly organized neural circuits requires interactions between neurons and glia. During the assembly of the Drosophila olfactory circuit, 50 olfactory receptor neuron (ORN) classes and 50 projection neuron (PN) classes form synaptic connections in 50 glomerular compartments in the antennal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu B,Li J,Chou YH,Luginbuhl D,Luo L

更新日期：2017-07-18 00:00:00

abstract：:Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Angle closure glaucoma, a common cause of glaucoma in Asia that affects tens of millions of people worldwide, often presents acutely with loss o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chi W,Li F,Chen H,Wang Y,Zhu Y,Yang X,Zhu J,Wu F,Ouyang H,Ge J,Weinreb RN,Zhang K,Zhuo Y

更新日期：2014-07-29 00:00:00

abstract：:T helper (Th) lymphocytes can develop memory for the expression of particular cytokines, like IL-4 or IL-10, in that reexpression of those cytokines is independent of the original costimulatory signal IL-4 and depends only on T cell receptor stimulation. Here, we show that in the course of Th2 cell differentiation in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Löhning M,Richter A,Stamm T,Hu-Li J,Assenmacher M,Paul WE,Radbruch A

更新日期：2003-10-14 00:00:00

abstract：:An array of photoreceptors including cryptochromes, phototropin, and phytochromes regulates various light responses in plants. Among these photoreceptors, phytochromes perceive red and far-red light by switching between two interconvertible spectral forms (Pr and Pfr). The Pfr form promotes light responses partly by d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paik I,Yang S,Choi G

更新日期：2012-01-24 00:00:00

abstract：:Electron micrographs are shown of the first component of human complement (C1) which has been crosslinked with a water-soluble carbodiimide to prevent dissociation into its C1q and C1r2C1s2 subunits. Two projections of the crosslinked molecule are seen in the electron micrographs, which are called "top" and "profile."...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strang CJ,Siegel RC,Phillips ML,Poon PH,Schumaker VN

更新日期：1982-01-01 00:00:00

abstract：:Necessary conditions are derived for a spherical vortex in a perfect fluid to be stationary in the case when the velocities depend on a single surface harmonic. The motion is indeterminate unless an additional condition is imposed. In the case when this condition is incompressibility, the equations are solved, yieldin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pekeris CL

更新日期：1972-09-01 00:00:00

abstract：:After intravitreal injection of gamma-[3H] aminobutyric acid (GAB), 2% of the neurons at the outer margin of the inner plexiform layer were intensely labeled. Reconstructions of these neurons from serial electron microscope autoradiograms showed that they are interplexiform cells, which synapse on bipolar processes in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,McGuire BA,Sterling P

更新日期：1980-01-01 00:00:00

abstract：:Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the direct characterization of amyloid polymorphism in hydrated and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cendrowska U,Silva PJ,Ait-Bouziad N,Müller M,Guven ZP,Vieweg S,Chiki A,Radamaker L,Kumar ST,Fändrich M,Tavanti F,Menziani MC,Alexander-Katz A,Stellacci F,Lashuel HA

更新日期：2020-03-24 00:00:00

abstract：:Infected cell protein 0 (ICP0) is a 775-residue multifunctional herpes simplex virus protein associated with numerous functions related to transactivation of gene expression and repression of host defenses to infection. We report that an uncharted domain of ICP0 located between residues 245 and 510 contains multiple S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang Y,Kurakin A,Roizman B

更新日期：2005-04-19 00:00:00

abstract：:MCF10A mammary epithelial cells form growth-arrested structures when cultured in three-dimensional basement membrane gels. Activation of the receptor tyrosine kinase ErbB2 induces formation of proliferative structures that share properties with noninvasive early stage lesions. We conducted a genetic screen to identify...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seton-Rogers SE,Lu Y,Hines LM,Koundinya M,LaBaer J,Muthuswamy SK,Brugge JS

更新日期：2004-02-03 00:00:00

abstract：:We have used electron microscopy to examine freshly isolated Salmonella typhimurium and Escherichia coli basal flagellar fragments, purified without resort to extremes of pH or ionic strength. Such fragments contain the large bell-like basal structures visualized recently in freeze-substituted or fixed preparations. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan IH,Reese TS,Khan S

更新日期：1992-07-01 00:00:00

abstract：:The resonance Raman excitation profiles of a number of charge transfer transitions in electron donor/acceptor complexes with tetracyanoethylene as acceptor in solution at room temperature are reported and compared with absorption and fluorescence spectra of these complexes. All complexes show distinct anomalies which ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michaelian KH,Rieckhoff KE,Voigt EM

更新日期：1975-11-01 00:00:00

abstract：:Focally evoked calcium waves in astrocyte cultures have been thought to propagate by gap-junction-mediated intercellular passage of chemical signal(s). In contrast to this mechanism we observed isolated astrocytes, which had no physical contact with other astrocytes in the culture, participating in a calcium wave. Thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hassinger TD,Guthrie PB,Atkinson PB,Bennett MV,Kater SB

更新日期：1996-11-12 00:00:00

abstract：:Genome engineering in human pluripotent stem cells (hPSCs) holds great promise for biomedical research and regenerative medicine. Recently, an RNA-guided, DNA-cleaving interference pathway from bacteria [the type II clustered, regularly interspaced, short palindromic repeats (CRISPR)-CRISPR-associated (Cas) pathway] h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou Z,Zhang Y,Propson NE,Howden SE,Chu LF,Sontheimer EJ,Thomson JA

更新日期：2013-09-24 00:00:00

abstract：:The enterotoxigenic Escherichia coli (ETEC) are among the most common causes of diarrheal illness and death due to diarrhea among young children in low-/middle-income countries (LMICs). ETEC have also been associated with important sequelae including malnutrition and stunting, placing children at further risk of death...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheikh A,Tumala B,Vickers TJ,Alvarado D,Ciorba MA,Bhuiyan TR,Qadri F,Singer BB,Fleckenstein JM

更新日期：2020-11-17 00:00:00

abstract：:LINEs are transposable elements found in various eukaryotes such as plants, protists, insects, and mammals. Their transposition is usually difficult to study, particularly in humans, where some diseases have been shown to result from LINE insertion mutations. This is due to the fact that most copies of any particular ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pélisson A,Finnegan DJ,Bucheton A

更新日期：1991-06-01 00:00:00

abstract：:DNA "breathing" is a thermally driven process in which base-paired DNA sequences transiently adopt local conformations that depart from their most stable structures. Polymerases and other proteins of genome expression require access to single-stranded DNA coding templates located in the double-stranded DNA "interior,"...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phelps C,Lee W,Jose D,von Hippel PH,Marcus AH

更新日期：2013-10-22 00:00:00

abstract：:Phenotypic alterations induced by the cytokinin 6-benzylaminopurine in cell suspensions of Nicotiana plumbaginifolia were studied at the level of the NH(2)-terminal sequence of the constituent proteins. Total protein extracts were separated by classical two-dimensional PAGE, and the proteins were recovered by electrob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bauw G,De Loose M,Inzé D,Van Montagu M,Vandekerckhove J

更新日期：1987-07-01 00:00:00