Flavohemoglobin Hmp protects Salmonella enterica serovar typhimurium from nitric oxide-related killing by human macrophages.

abstract：:Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an important host-protective antigen. However, this molecule is toxic and requires inactivation prior to its use as a vaccine. Three genetically toxoided, nonhemolytic PLO molecules, HIS-PLO.F(497), HIS-PLO.Delta P(499), and HI...

journal_title：Infection and immunity

authors： Jost BH,Trinh HT,Songer JG,Billington SJ

更新日期：2003-05-01 00:00:00

abstract：:The proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) induces lethal hepatitis when injected into D-(+)-galactosamine-sensitized mice on the one hand or systemic inflammatory response syndrome (SIRS) in normal mice on the other hand. We studied whether serum amyloid P component (SAP), the major acute-ph...

journal_title：Infection and immunity

authors： Van Molle W,Hochepied T,Brouckaert P,Libert C

更新日期：2000-09-01 00:00:00

abstract：:Using pharmacologic and biochemical criteria, we evaluated whether uptake of four different Chlamydia trachomatis serovars, D, E, K, and L2, was dependent upon lipid rafts. Our data suggest that lipid raft-mediated entry is not required for C. trachomatis infection of cultured epithelial cells. ...

journal_title：Infection and immunity

authors： Gabel BR,Elwell C,van Ijzendoorn SC,Engel JN

更新日期：2004-12-01 00:00:00

abstract：:The attachment of Staphylococcus aureus (Cowan I) and two strains of group A and G streptococci on glass cover slips coated with fibronectin, fibronectin fragments, or fibrinogen was studied. The attachment was quantitated by counting the attached bacteria on glass surfaces coated with a similar molarity of the protei...

journal_title：Infection and immunity

authors： Kuusela P,Vartio T,Vuento M,Myhre EB

更新日期：1985-10-01 00:00:00

abstract：:Secretory immunoglobulin A (SIgA) antibodies directed against the O antigen of lipopolysaccharide (LPS) are the primary determinants of mucosal immunity to gram-negative enteric pathogens. However, the underlying mechanisms by which these antibodies interfere with bacterial colonization and invasion of intestinal epit...

journal_title：Infection and immunity

authors： Forbes SJ,Eschmann M,Mantis NJ

更新日期：2008-09-01 00:00:00

abstract：:The purpose of the present study was to determine the extent of immunologic responses, particularly immunopathologic responses, within the upper and lower respiratory tracts after intranasal immunization using the mucosal adjuvant cholera toxin (CT). BALB/c mice were nasally immunized with influenza virus vaccine comb...

journal_title：Infection and immunity

authors： Hodge LM,Marinaro M,Jones HP,McGhee JR,Kiyono H,Simecka JW

更新日期：2001-04-01 00:00:00

abstract：:The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

journal_title：Infection and immunity

authors： Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

更新日期：1980-11-01 00:00:00

abstract：:In this study, the role of the hepatobiliary system in the early pathogenesis of Salmonella enteritidis infection was investigated in a rat model. Intravenous (i.v.) challenge with lipopolysaccharide (LPS) has previously been shown to enhance the translocation of normal gut flora. We first confirmed that LPS can simil...

journal_title：Infection and immunity

authors： Islam AF,Moss ND,Dai Y,Smith MS,Collins AM,Jackson GD

更新日期：2000-01-01 00:00:00

abstract：:The role of the alternative sigma factor sigma(B) in Staphylococcus epidermidis was investigated by the construction, complementation, and characterization of a sigB deletion mutant. Electrophoretic analyses confirmed a profound influence of sigma(B) on the expression of exoproteins and cytoplasmic proteins. Detailed ...

journal_title：Infection and immunity

authors： Kies S,Otto M,Vuong C,Götz F

更新日期：2001-12-01 00:00:00

abstract：:Oxygen consumption by Treponema pallidum was observed to be glucose dependent. Treponemes consumed O2 to a low dissolved O2 concentration of 0.01 mumol of O2 per ml when respiration ceased. A fermentative degradation of glucose occurred during the maintenance of treponemes at 0.01 mumol of O2 per ml. Although the init...

journal_title：Infection and immunity

authors： Barbieri JT,Cox CD

更新日期：1981-03-01 00:00:00

abstract：:Trefoil family factor 2 (TFF2), also known as spasmolytic peptide, is a low-molecular-weight protein that is upregulated in gastric tissues infected with Helicobacter or having other inflammatory conditions, but a precise function is yet to be elucidated. The role of TFF2 in the development of gastritis, colitis, and ...

journal_title：Infection and immunity

authors： Kurt-Jones EA,Cao L,Sandor F,Rogers AB,Whary MT,Nambiar PR,Cerny A,Bowen G,Yan J,Takaishi S,Chi AL,Reed G,Houghton J,Fox JG,Wang TC

更新日期：2007-01-01 00:00:00

abstract：:In previous work, we identified xanthine oxidase (XO) as an important enzyme in the interaction between the host and enteropathogenic Escherichia coli(EPEC) and Shiga-toxigenic E. coli(STEC). Many of the biological effects of XO were due to the hydrogen peroxide produced by the enzyme. We wondered, however, if uric ac...

journal_title：Infection and immunity

authors： Crane JK,Broome JE,Lis A

更新日期：2016-03-24 00:00:00

abstract：:The gram-negative gastric pathogen Helicobacter pylori is equipped with an extraordinarily large set of outer membrane proteins (OMPs), whose role in the infection process is not well understood. The Hop (Helicobacter outer membrane porins) and Hor (Hop-related proteins) groups constitute a large paralogous family con...

journal_title：Infection and immunity

authors： Odenbreit S,Swoboda K,Barwig I,Ruhl S,Borén T,Koletzko S,Haas R

更新日期：2009-09-01 00:00:00

abstract：:We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in th...

journal_title：Infection and immunity

authors： Babu S,Ganley LM,Klei TR,Shultz LD,Rajan TV

更新日期：2000-05-01 00:00:00

abstract：:Bactericidal activity and binding of a 57,000-dalton cationic antimicrobial neutrophil granule protein (CAP57) are determined by the presence on bacteria of O-antigen polysaccharide chains and the availability of negatively charged groups in the lipid A region, the inner core region, or both regions of lipopolysacchar...

journal_title：Infection and immunity

authors： Farley MM,Shafer WM,Spitznagel JK

更新日期：1988-06-01 00:00:00

abstract：:Gardnerella vaginalis, the bacterial species most frequently isolated from women with bacterial vaginosis (BV), produces a cholesterol-dependent cytolysin (CDC), vaginolysin (VLY). At sublytic concentrations, CDCs may initiate complex signaling cascades crucial to target cell survival. Using live-cell imaging, we obse...

journal_title：Infection and immunity

authors： Randis TM,Zaklama J,LaRocca TJ,Los FC,Lewis EL,Desai P,Rampersaud R,Amaral FE,Ratner AJ

更新日期：2013-12-01 00:00:00

abstract：:The toxicity of Chlamydia trachomatis was studied with mouse peritoneal macrophage culture. Inoculation of 30 inclusion-forming units of trachoma B/TW-5/OT organisms and 250 inclusion-forming units of lymphogranuloma venereum L2/434/Bu organisms per cell caused immediated toxicity, with the killing of 40 to 90% of the...

journal_title：Infection and immunity

authors： Kuo CC

更新日期：1978-06-01 00:00:00

abstract：:Chemokines (CK) are potent leukocyte activators and chemoattractants and aid in granuloma formation, functions critical for the immune response to Mycobacterium tuberculosis. We hypothesized that infection of alveolar macrophages (AM) with different strains of M. tuberculosis elicits distinct profiles of CK, which cou...

journal_title：Infection and immunity

authors： Saukkonen JJ,Bazydlo B,Thomas M,Strieter RM,Keane J,Kornfeld H

更新日期：2002-04-01 00:00:00

abstract：:There is an emerging paradigm shift from coronary heart disease having a purely hereditary and nutritional causation to possibly having an infectious etiology. Recent epidemiological studies have shown a correlation between periodontal disease and coronary heart disease. However, to date, there is minimal information ...

journal_title：Infection and immunity

authors： Dorn BR,Dunn WA Jr,Progulske-Fox A

更新日期：1999-11-01 00:00:00

abstract：:The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp protein and activity are ...

journal_title：Infection and immunity

authors： Szeto L,Shuman HA

更新日期：1990-08-01 00:00:00

abstract：:Susceptibility of Syrian hamsters of the inbred LSH and MHA strains to injection of as few as 10 plaque-forming units of vesicular stomatitis virus (VSV) was shown to occur only after intraperitoneal and intrapleural injection and not after injection of VSV intravenously, intranasally, or in the footpads. Despite the ...

journal_title：Infection and immunity

authors： Fultz PN,Shadduck JA,Kang CY,Streilein JW

更新日期：1981-11-01 00:00:00

abstract：:Bovine tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) cDNAs were generated by reverse transcription and then by PCR amplification from lipopolysaccharide (LPS)-stimulated alveolar macrophage RNA. The amplified cDNAs were cloned into pPow and expressed in Escherichia coli DH5 alpha. The expr...

journal_title：Infection and immunity

authors： Yoo HS,Maheswaran SK,Lin G,Townsend EL,Ames TR

更新日期：1995-02-01 00:00:00

abstract：:No effective therapy exists for Cryptosporidium parvum, a coccidial protozoan parasite that causes severe diarrhea in patients with AIDS. The role of microtubules in parasite invasion of host cells was investigated by incubating 10(7) oocysts with a HT 29.74 cell line for 24 h in the presence of microtubule-disrupting...

journal_title：Infection and immunity

authors： Wiest PM,Johnson JH,Flanigan TP

更新日期：1993-11-01 00:00:00

abstract：:In vitro studies have shown that enterotoxigenic Escherichia coli (ETEC) strains are capable of invading cultured epithelial cells derived from the human ileum and colon. Two separate invasion loci (tia and tib) have previously been isolated from the classical ETEC strain H10407. The tia locus has been shown to direct...

journal_title：Infection and immunity

authors： Mammarappallil JG,Elsinghorst EA

更新日期：2000-12-01 00:00:00

abstract：:A modified version of the Bacteroides fragilis transposon Tn4400, designated Tn4400', enabling rapid isolation and analysis of B. fragilis mutants has been constructed. To identify potential virulence factors, Tn4400'-generated mutants were screened by a new method; this resulted in the isolation of 21 mutant strains ...

journal_title：Infection and immunity

authors： Tang YP,Malamy MH

更新日期：2000-01-01 00:00:00

abstract：:We report on the colonization of murine trigeminal ganglia after sequential infection of mice by herpes simplex viruses (HSVs). In preliminary studies, we have established that whereas the HSV-1(F) strain efficiently colonizes ganglia when inoculated by either the ear or eye routes, the HSV-1 X HSV-2 recombinant C7D c...

journal_title：Infection and immunity

authors： Meignier B,Norrild B,Roizman B

更新日期：1983-08-01 00:00:00

abstract：:After aerosol deposition of Serratia marcescens in mice, initial delayed pulmonary clearance was followed between 4 and 24 hr later by progressive elimination. ...

journal_title：Infection and immunity

authors： Southern PM,Pierce AK,Sanford JP

更新日期：1971-01-01 00:00:00

abstract：:Agglutinogen 1 of Bordetella pertussis strain 353/Z (serotype 1) was separated from protective antigen and histamine-sensitizing factor by starch-block electrophoresis. Most of the agglutinogen 1 migrated towards the cathode in starch-block electrophoresis, although some remained near the origin. Fractions containing ...

journal_title：Infection and immunity

authors： Ross RF,Munoz J

更新日期：1971-02-01 00:00:00

abstract：:Merozoite surface proteins of Plasmodium falciparum play a critical role in the invasion of human erythrocytes by the malaria parasite. Here we describe the identification of a novel protein with a molecular mass of 40 kDa that is found on the merozoite surface of P. falciparum. We call this protein merozoite surface ...

journal_title：Infection and immunity

authors： Marshall VM,Silva A,Foley M,Cranmer S,Wang L,McColl DJ,Kemp DJ,Coppel RL

更新日期：1997-11-01 00:00:00

abstract：:Cytokine gene expression in cells migrating in afferent and efferent intestinal lymph was monitored for extended time periods in individual sheep experimentally infected with the nematode Trichostrongylus colubriformis. Animals from stable selection lines with increased levels of either genetic resistance (R) or susce...

journal_title：Infection and immunity

authors： Pernthaner A,Cole SA,Morrison L,Hein WR

更新日期：2005-04-01 00:00:00