Abstract:
:The proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) induces lethal hepatitis when injected into D-(+)-galactosamine-sensitized mice on the one hand or systemic inflammatory response syndrome (SIRS) in normal mice on the other hand. We studied whether serum amyloid P component (SAP), the major acute-phase protein in mice, plays a protective role in both lethal models. For this purpose, we used SAP(0/0) mice generated by gene targeting. We studied the lethal response of SAP(0/0) or SAP(+/+) mice to both lethal triggers but found no differences in the sensitivity of both types of mice. We also investigated whether SAP is involved in establishing two types of endogenous protection: one using a single injection of interleukin-1beta (IL-1beta) for desensitization and clearly involving a liver protein, the other by tolerizing mice for 5 days using small doses of human TNF-alpha. Although after IL-1beta or after tolerization the SAP levels in the serum had risen fourfold in the control mice and not in the SAP(0/0) mice, the same extents of desensitization and tolerization were achieved. Finally, we observed that the induction of hemorrhagic necrosis in the skin of mice by two consecutive local injections with TNF-alpha was not altered in SAP(0/0) mice. We conclude that the presence or absence of SAP has no influence on the sensitivity of mice to TNF-alpha-induced hepatitis, SIRS, and hemorrhagic necrosis or on the endogenous protective mechanisms of desensitization or tolerization.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Van Molle W,Hochepied T,Brouckaert P,Libert Cdoi
10.1128/iai.68.9.5026-5029.2000keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
5026-9issue
9eissn
0019-9567issn
1098-5522journal_volume
68pub_type
杂志文章abstract::Stimulation of the rabbit reticuloendothelial system with viable Mycobacterium bovis (strain BCG), and other agents, had no effect on the development of syphilitic lesions after intradermal or intravenous inoculation with graded doses of Treponema pallidum (virulent Nichol's strain; mean infective doses less than 10)....
journal_title:Infection and immunity
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doi:10.1128/IAI.12.5.1029-1036.1975
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.9.3928-3932.1993
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pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3199-3208.1993
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.8.1942-1949.1988
更新日期:1988-08-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.12.6.1415-1425.1975
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.43.2.531-535.1984
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1988-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.3.886-892.1986
更新日期:1986-12-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1994-10-01 00:00:00