Abstract：
:Recent investigations have suggested that changes in contractile protein expression contribute to reductions in skeletal muscle function during congestive heart failure (CHF). Myosin heavy chain (MHC), a major contractile protein, has been shown to undergo alterations in protein isoform expression during CHF. The purpose of this investigation was twofold: (1) to determine whether muscles of the same functional group undergo similar changes in MHC expression, and (2) determine whether the magnitude of alterations in MHC is related to the severity of CHF. Using the rat coronary ligation model, mild and severe forms of CHF were produced and muscles of the plantar flexor group were analyzed. Whole-muscle MHC isoform proportions were not altered in the soleus and white gastrocnemius muscle, however significant increases in the percentage of fast MHC isoforms (7-9% increases in MHC IIx and IIb expression) were found in the red gastrocnemius muscle. In addition, there were significant proportional increases (8%) in MHC type IIb at the expense of MHC type IIx in the plantaris muscle. Many of the changes in the proportions of MHC isoforms were significantly correlated with indices of CHF severity. This indicates that changes in skeletal muscle MHC isoform expression are related to the severity of CHF and suggests that some peripheral skeletal muscles are more susceptible to shifts in MHC expression due to CHF. These changes in MHC isoform expression may contribute to alterations in the physiological performance of skeletal muscle and exercise capacity during CHF.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Spangenburg EE,Talmadge RJ,Musch TI,Pfeifer PC,McAllister RM,Williams JHdoi
10.1007/s00421-002-0615-3keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
182-6issue
2eissn
1439-6319issn
1439-6327journal_volume
87pub_type
杂志文章abstract：:This study systematically examined the role of work rate (WR) increment on the kinetics of pulmonary oxygen uptake (VO(2p)) and near-infrared spectroscopy (NIRS)-derived muscle deoxygenation (Δ[HHb]) during moderate-intensity (Mod) cycling. Fourteen males (24 ± 5 years) each completed four to eight repetitions of Mod ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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更新日期：2007-04-01 00:00:00
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
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journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
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abstract：:Whole body vibration (WBV) is a novel modality that has been demonstrated to enhance muscular and cardiovascular functions reported to increase fibrinolytic activity. The purpose of this study was to examine the fibrinolytic response to WBV and exercise in men. Twenty healthy males (23.8 ± 0.9 years, 25.6 ± 0.2 kg m(-...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
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更新日期：2010-11-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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