Abstract：
:A common null polymorphism (rs1815739; R577X) in the gene that codes for α-actinin-3 (ACTN3) has been related to different aspects of exercise performance. Individuals who are homozygous for the X allele are unable to express the α-actinin-3 protein in the muscle as opposed to those with the RX or RR genotype. α-actinin-3 deficiency in the muscle does not result in any disease. However, the different ACTN3 genotypes can modify the functioning of skeletal muscle during exercise through structural, metabolic or signaling changes, as shown in both humans and in the mouse model. Specifically, the ACTN3 RR genotype might favor the ability to generate powerful and forceful muscle contractions. Leading to an overall advantage of the RR genotype for enhanced performance in some speed and power-oriented sports. In addition, RR genotype might also favor the ability to withstand exercise-induced muscle damage, while the beneficial influence of the XX genotype on aerobic exercise performance needs to be validated in human studies. More information is required to unveil the association of ACTN3 genotype with trainability and injury risk during acute or chronic exercise.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Del Coso J,Hiam D,Houweling P,Pérez LM,Eynon N,Lucía Adoi
10.1007/s00421-018-4010-0subject
Has Abstractpub_date
2019-01-01 00:00:00pages
49-60issue
1eissn
1439-6319issn
1439-6327pii
10.1007/s00421-018-4010-0journal_volume
119pub_type
杂志文章,评审abstract：PURPOSE:Equations for blood oxyhemoglobin (HbO2) and carbaminohemoglobin (HbCO2) dissociation curves that incorporate nonlinear biochemical interactions of oxygen and carbon dioxide with hemoglobin (Hb), covering a wide range of physiological conditions, are crucial for a number of practical applications. These include...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-015-3228-3
更新日期：2016-01-01 00:00:00
abstract：: ...
journal_title：European journal of applied physiology
pub_type： 评论,信件
doi：10.1007/s00421-018-3990-0
更新日期：2018-12-01 00:00:00
abstract：:We tested the hypothesis that a low level of regular daily physical activity in elderly individuals would be associated with a clinically significant degree of sarcopenia. Subjects were 78 male and 97 female free-living Japanese, aged 65-84 years. A pedometer/accelerometer measured continuously the number of steps tak...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1424-8
更新日期：2010-07-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-019-04097-7
更新日期：2019-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2010-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3631-z
更新日期：2017-07-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04300-0
更新日期：2020-02-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-001-0557-1
更新日期：2002-02-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-009-1140-4
更新日期：2009-11-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2305-5
更新日期：2012-09-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-010-1801-3
更新日期：2011-08-01 00:00:00
abstract：:Information concerning the validity and reliability of commercial on-line gas analysis systems is limited. The aim of this study was to provide a comparison of the validity and reliability of three on-line systems (Oxycon Alpha, Oxycon Pro and Pulmolab EX670) with that of Douglas bags. Two separate studies were conduc...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-001-0572-2
更新日期：2002-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-016-3357-3
更新日期：2016-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2119-5
更新日期：2012-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-0090-8
更新日期：2006-03-01 00:00:00
abstract：:In order to quantify the seasonal variability of haemoglobin mass (Hb(mass)) in cyclists during a competitive season, and investigate whether variability is associated with changes in training load or performance, Hb(mass) was measured in 10 internationally competitive female road cyclists approximately once per month...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-009-1349-2
更新日期：2010-05-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-0016-5
更新日期：2005-12-01 00:00:00
abstract：:Thirty-two untrained men [mean (SD) age 22.5 (5.8) years, height 178.3 (7.2) cm, body mass 77.8 (11.9) kg] participated in an 8-week progressive resistance-training program to investigate the "strength-endurance continuum". Subjects were divided into four groups: a low repetition group (Low Rep, n = 9) performing 3-5 ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-002-0681-6
更新日期：2002-11-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-012-2434-5
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:Changes in mean skin temperature (Tsk) have been shown to modify the maximum rate of sweat ion reabsorption. This study aims to extend this knowledge by investigating if modifications could also be caused by local Tsk. METHODS:The influence of local Tsk on the sweat gland maximum ion reabsorption rates was inv...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-018-04059-5
更新日期：2019-03-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210100484
更新日期：2001-08-01 00:00:00
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journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-015-3127-7
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:Swimming exercise leads to a nonpathological, physiological left ventricular hypertrophy. However, the potential molecular mechanisms are unknown. We investigated the role of microRNAs (miRNA) regulating the cardiac signal cascades were studied in exercised rats. METHODS:Female Wistar rats were assigned into t...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-013-2685-9
更新日期：2013-10-01 00:00:00
abstract：PURPOSE:The present study was designed to determine the stimulation intensity necessary for an adequate assessment of central and peripheral components of neuromuscular fatigue of the knee extensors. METHODS:Three different stimulation intensities (100, 120 and 150% of the lowest intensity evoking a plateau in M-waves...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-013-2760-2
更新日期：2014-01-01 00:00:00
abstract：:The aim of our study was to compare long distance runners to body mass index (BMI)- and age-matched healthy controls with respect to bone parameters at all relevant loaded and nonloaded skeletal sites. Furthermore, we assessed the effect of running volume on bone parameters. Twenty elite male runners (21.1 km<1:15 h; ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-0060-1
更新日期：2006-01-01 00:00:00
abstract：:Future activities in space will require greater periods of time in extreme environments in which the body periphery will be vulnerable to chilling. Maintaining the hands and fingers in comfortable conditions enhances finger flexibility and dexterity, and thus effects better work performance. We have evaluated the effi...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210050658
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:The purpose of this double-blind, placebo-controlled study was to examine the effect of two fish oil supplements, one high in EPA (750 mg EPA, 50 mg DHA) and one low in EPA (150 mg EPA, 100 mg DHA), taken acutely as a recovery strategy following EIMD. METHODS:Twenty-seven physically active males (26 ± 4 year, ...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3543-y
更新日期：2017-03-01 00:00:00
abstract：PURPOSE:We investigated the effects of a 3-week dietary periodization on immunity and sleep in triathletes. METHODS:21 triathletes were divided into two groups with different nutritional guidelines during a 3-week endurance training program including nine twice a day sessions with lowered (SL group) or maintained (CON...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-016-3446-3
更新日期：2016-10-01 00:00:00
abstract：:Prolonged immobilization of the human body results in functional impairments and musculoskeletal system deconditioning that may be attenuated by adequate muscle exercise. In a 56-day horizontal bed rest campaign involving voluntary males we investigated the effects of vibration muscle exercise (RVE, 2x6 min daily) on ...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-006-0160-6
更新日期：2006-06-01 00:00:00
abstract：PURPOSE:With aging, there tends to be an increase in retrograde and oscillatory shear in peripheral conduit arteries of humans. Whether the increase in shear rate is due to the aging process or an effect of a less active lifestyle that often accompanies aging is unknown. Therefore, we examined whether chronic endurance...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-016-3445-4
更新日期：2016-10-01 00:00:00
