Abstract:
:Radiolabelled recombinant human interleukin-8 (IL-8) with its homologue neutrophil-activating peptide-2 (NAP-2) have been compared for imaging acute sterile inflammatory lesions in rats. 125I-IL-8 and 125I-NAP-2 were prepared by reaction with chloramine-T and injected intravenously into male rats bearing subcutaneous carrageenan abscesses in their left hindlimbs. Left hindlimb and right hindlimb activities were determined from serial total-body scintigrams between 1 h and 96 h post-injection as regional per cent injected activity corrected for physical decay (%IA). Time-activity curves for 125I-IL-8 and 125I-NAP-2 in the carrageenan-containing left hindlimbs were similar in that both peaked at 1-3 h post-injection (IL-8, 4.9+/-0.5%IA; NAP-2, 4.8+/-1.9%IA) and decreased exponentially thereafter. However, while the lesioned-to-control limb activity ratio (L/C) for 125I-IL-8 only approximately doubled during the imaging period (1.7+/-0.3 at 1 h vs 3.7+/-1.0 at 24 h post-injection), L/C for 125I-NAP-2 more than tripled, rising from 1.5+/-0.4 at 1 h to 5.3+/-0.7 by 72 h post-injection. It is concluded that while both radiolabelled IL-8 and NAP-2 may prove useful for clinical imaging, radiolabelled NAP-2 may provide better discrimination of inflammatory lesions from normal tissue at later times post-injection.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Hay RV,Skinner RS,Newman OC,Kunkel SL,Lyle LR,Shapiro B,Gross MDdoi
10.1097/00006231-200204000-00010keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
367-72issue
4eissn
0143-3636issn
1473-5628journal_volume
23pub_type
杂志文章abstract::Uterine leiomyomas, benign tumours of the human uterus, are the most common uterine neoplasm and are composed of smooth muscle with varying amounts of fibrous connective tissue. As a functional imaging modality, 2-[F]fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography can be used to obtain information about ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200409000-00012
更新日期:2004-09-01 00:00:00
abstract:AIM:The first pathogenetic step in multiple myeloma is the emergence of a limited number of clonal plasma cells, clinically known as monoclonal gammopathy of undetermined significance (MGUS). Patients with MGUS do not have symptoms or end-organ damage but they do have a 1% annual risk of progression to multiple myeloma...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f5e5df
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:This study aimed to assess the efficacy of fluorine-18 fluorodeoxyglucose (F-FDG)-PET for predicting overall survival (OS) and disease-free survival (DFS) in oesophageal cancer patients after definitive chemoradiotherapy (CRT) and prognostic importance of metabolic response detected by post-treatment PET at ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000594
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The regions of significant correlation between cerebral hypoperfusion and neuropsychological assessment scores were evaluated using (99m)Tc-HMPAO SPECT in patients with mild cognitive impairment (MCI) on the basis of its three subtypes, namely, single-domain amnestic MCI (aMCI-s), multiple-domain amnestic MCI (...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32835587f8
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Paediatric dual X-ray absorptiometry (DXA) studies present a number of technical problems. One of these is that the edge detection algorithms designed for the adult skeleton may fail for paediatric studies. Hologic provide alternative algorithms for low bone density studies. AIM:To assess low-density softwa...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200506000-00002
更新日期:2005-06-01 00:00:00
abstract:AIM:This study aims to assess the diagnostic role of F-FDG PET/computed tomography in primary staging and restaging of testicular cancer in comparison with contrast-enhanced diagnostic thoracic-abdominopelvic computed tomography. MATERIAL AND METHOD:Thirty-two consecutive male patients with testicular carcinoma (media...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001093
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Trastuzumab (T) and anthracycline (A)-based chemotherapy is considered the standard of care in human epidermal growth factor receptor-2+ overexpressing breast cancer, but requires monitoring for known cardiotoxicity using left ventricular (LV) ejection fraction (EF) every 3-4 months during treatment. It is n...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000941
更新日期:2019-01-01 00:00:00
abstract::We investigated a simple and reliable method for the preparation of 99Tcm-dimercaptosuccinic acid (99Tcm(V)-DMSA) without the addition of oxygen. The effect of pH, amount of reducing agent, and oxygen addition in the synthesis of 99Tcm(V)-DMSA were evaluated. At pH 9, we obtained a radiochemical yield of 95% +/- 1.2% ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200106000-00002
更新日期:2001-06-01 00:00:00
abstract::Reticuloendothelial system (RES) phagocytic function or capacity can be measured by clearance studies with test substances. This study in the rat examines three commercially available 99Tcm-labelled test substances, and different methods of calculating RES capacity. Albures size 500 nm and sulphur colloid size 600 nm ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198705000-00004
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVES:Ewing sarcoma breakpoint region 1 (EWSR1) translocation-negative tumors represent a minor portion of small round cell tumors consistent with Ewing sarcoma morphology. The purpose of this study was to differentiate EWSR1 translocation-positive tumors from EWSR1 translocation-negative tumors using PET-computed...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001031
更新日期:2019-08-01 00:00:00
abstract::Esophageal cancer is the third most common malignancy of the alimentary tract. The incidence of esophageal cancer has steadily increased over the past three decades. Almost all therapeutic modalities for esophageal cancer are associated with a considerable mortality and morbidity. Consequently, there has been growing ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e32831af204
更新日期:2009-02-01 00:00:00
abstract::A technique is described for the quantification of the three-dimensional distribution of 131I radiopharmaceuticals using single photon emission computed tomography (SPECT). A theoretical discussion of the problems of scatter and septal penetration in 131I SPECT is presented. The correction of these effects using the g...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199306000-00014
更新日期:1993-06-01 00:00:00
abstract::To assess the precision of gated equilibrium radioventriculography in measuring changes in left ventricular stroke volume (LVSV), we studied five dogs each with a chronically implanted electromagnetic flowmeter on the ascending aorta. Per cent changes in left ventricular stroke counts (LVSC) were compared to those in ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198812000-00009
更新日期:1988-12-01 00:00:00
abstract:BACKGROUND:To compare the accuracy of various equations for estimating glomerular filtration rate. METHODS:Chronic kidney disease was classified by Tc-DTPA scintigraphy (reference glomerular filtration rate), estimating glomerular filtration rate was estimated using various formulas. The similarity to reference glomer...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001141
更新日期:2020-03-01 00:00:00
abstract:AIM:99mTc-HL91 is a new hypoxia agent and can identify acutely ischaemic viable myocardium in a canine model using a standard gamma camera. The purpose of the study was to determine whether this tracer could be used to detect regional ischaemia in chronic ischaemic myocardium in a swine model. METHOD:Using a porcine m...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200512000-00012
更新日期:2005-12-01 00:00:00
abstract::Positron emission tomography (PET) is increasingly used clinically to provide functional information on disease processes, especially in oncology using the glucose analogue 2-[18F]fluoro-2-deoxy-D-glucose (F-FDG). In the clinical setting it has become standard practice to use simplified imaging protocols compared to t...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/01.mnm.0000134327.85170.6b
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:Concurrent inflammation or anemia at the time of PET/computed tomography (CT) could be one of several causes of diffuse splenic (18)F-fluorodeoxyglucose ((18)F-FDG) uptake. In this study, we focused on cytokines to investigate interactions during this phenomenon and clarify the significance of splenic (18)F-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e3283595cac
更新日期:2013-01-01 00:00:00
abstract::One hundred and twenty-eight patients had a stress test with sestamibi injection and a coronarography within 2 months of the sestamibi study. Sestamibi studies were reconstructed using Hanning 0.65 and Wiener 1.0 filters; the latter improved the results significantly (P < 0.05). Significant correlations were found bet...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199301000-00006
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Positron emission tomography (PET) imaging using [18F]fluorodeoxyglucose (18F-FDG) is recognized to have a major role in oncological imaging. Over recent years there has been a steady increase in the use of gamma camera PET (GCPET) systems as these are less expensive than dedicated PET scanners and facilitat...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000130239.76326.ca
更新日期:2004-07-01 00:00:00
abstract:AIM:To test the applicability of Tc-dextran joint scintigraphy in the assessment of disease activity in patients with rheumatoid arthritis (RA), and to compare it with the clinical disease activity scores and laboratory parameters. METHODS:Twenty-seven patients with RA were investigated using Tc-dextran joint scintigr...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/01.mnm.0000126632.32413.2e
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the efficacy of low-dose and high-dose (99m)Tc methoxy isobutyl isonitrile (MIBI) protocols in intraoperative localization of parathyroid adenomas by means of a gamma probe in patients with primary hyperparathyroidism (PHPT). PATIENTS AND METHODS:The study included 62 pat...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000056
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:To prevent salivary dysfunction in thyroid cancer patients who have undergone radioiodine ablation, massaging the parotid gland (PG) is presumed to be helpful for the removal of radioiodine. The purpose of this study was to evaluate the effect of PG massage in the removal of radioiodine from the PG. METHODS...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,随机对照试验
doi:10.1097/MNM.0000000000000176
更新日期:2014-11-01 00:00:00
abstract::The aims of this study were to develop an objective method for assessing rCBF deficits using a statistical image analysis protocol and to validate its effective use in clinical practice. 99Tcm-HMPAO brain SPET images were acquired for 40 normal subjects, 10 patients with Alzheimer's disease and 10 patients with depres...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199901000-00006
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Radium-223 was a treatment approved for patients with metastatic castrate-resistant prostate cancer, symptomatic bone metastases and no-visceral metastases, in progression after at least two prior lines of systemic therapy, or ineligible for any available systemic treatment. The aim of this study was to prov...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001164
更新日期:2020-04-01 00:00:00
abstract::Chronic synovitis often occurs in people with haemophilia. Untreated chronic haemophilic synovitis affects the metabolism of chondrocytes, thus leading to haemophilic arthropathy. A recently introduced therapeutic protocol includes radiation synovectomy (RS), a safe and cost-effective therapeutic method, which has giv...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:10.1097/MNM.0b013e32835ed50c
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:Collecting positron emission tomography data in three-dimensional (3D) mode may potentially allow reduction of the tracer dose and/or the acquisition time without compromising image quality thereby making the procedure more patient-friendly and cost effective. The objective of our study was to compare VUE Poi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/mnm.0b013e328315a22a
更新日期:2009-01-01 00:00:00
abstract:AIM:The objective of this study was to assess the relevance of physiological (68)Ga-DOTATATE PET/CT findings in the pancreas guided by morphological imaging (MI) in comparison with pathological tumour uptake in patients with neuroendocrine tumours (NETs). METHODS:A total of 138 patients with pancreatic NET (pNET; n=38...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000106
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Respiratory gated perfusion single photon emission computed tomography (SPECT) was applied to reduce respiratory lung motion effects and to reliably assess perfusion impairment in various lung diseases. METHODS:After injection of 259 MBq of 99mTc macroaggretated albumin (99mTc-MAA), gating was performed using ...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200402000-00016
更新日期:2004-02-01 00:00:00
abstract::The physical considerations of using dual isotope brain SPECT imaging to monitor blood flow changes during cognitive activation studies were investigated. These factors included field uniformity, spatial resolution and crosstalk. Serial dual isotope single photon emission computed tomographic (SPECT) studies of a test...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199305000-00008
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the diagnostic value of function volume/morphological volume ratio calculated from ventilation/perfusion single-photon emission computed tomography/computed tomography in distinguishing the lungs with bronchiolitis obliterans syndrome (BOS) from the lungs without this syndrome after lung transplan...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001021
更新日期:2019-07-01 00:00:00