Biomarkers specific to densely-ionising (high LET) radiations.

Abstract:

:There have been several suggestions of biomarkers that are specific to high LET radiation. Such a biomarker could significantly increase the power of epidemiological studies of individuals exposed to densely-ionising radiations such as alpha particles (e.g. radon, plutonium workers, individuals exposed to depleted uranium) or neutrons (e.g. radiation workers, airline personnel. We discuss here a potentially powerful high LET biomarker (the H value) which is the ratio of induced inter-chromosomal aberrations to intra-arm aberrations. Both theoretical and experimental studies have suggested that this ratio should differ by a factor of about three between high LET radiation and any other likely clastogen, and will yield more discrimination than the previously suggested F value (ratio of inter-chromosomal aberrations to intra-chromosomal inter-arm aberrations). Evidence of the long-term stability of such chromosomal biomarkers has also been generated. Because these stable intra-arm anld inter-chromosomal aberrations are (1) frequent and (2) measurable at long times after exposure, this H value appears to be a practical biomarker of high LET exposure, and several in vitro studies have confirmed the approach for unstable aberrations. The approach is currently being tested in a population of Russian radiation workers exposed several decades ago to high- or low LET radiation.

journal_name

Radiat Prot Dosimetry

authors

Brenner DJ,Okladnikova N,Hande P,Burak L,Geard CR,Azizova T

doi

10.1093/oxfordjournals.rpd.a006640

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

69-73

issue

1

eissn

0144-8420

issn

1742-3406

journal_volume

97

pub_type

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