Filter, collimator and moderating material to achieve boron neutron capture enhanced fast neutron therapy.

Abstract:

:The combination of fast neutron therapy and boron neutron capture therapy is currently being studied as a possible treatment for some radio-resistant brain tumours. In an attempt to design a boron-enhanced fast neutron therapy beam for the Fermilab Fast Neutron Therapy Facility, the use of moderating material surrounding the patient's head has been investigated. Graphite, polyethylene, water and heavy water were studied as moderating materials, using MCNP. The use of tungsten, iron, lead and bismuth as materials for a small filter and collimator near the patient's head was investigated. Calculations showed that a filter and collimator made of tungsten with a graphite moderator was capable of producing a dose enhancement of 17.3 +/- 0.6% for a 100 microg g(-1) loading of 10B for a 5.6 cm diameter beam while delivering 1.5 Gy in 7 min.

journal_name

Radiat Prot Dosimetry

authors

Sweezy J,Hertel N,Lennox A

doi

10.1093/rpd/nci256

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

470-4

issue

1-4 Pt 2

eissn

0144-8420

issn

1742-3406

journal_volume

116

pub_type

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