Abstract:
:Adenoviral DNA was examined within capsids by dimethyl sulfate footprinting. Protein-DNA interactions were visualized through ligation-mediated PCR (LM-PCR). Signals for protein binding were found adjacent to both inverted terminal repeats (ITR). There were no indications of close protein binding at several other loci of the viral genome. Therefore, adenovirus type 5 seems to contain sequence- or locus-specific DNA binding proteins within the virion.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Dobner T,Büchner D,Zeller T,Wolf H,Niller HHdoi
10.1515/BC.2001.169keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
1373-7issue
9eissn
1431-6730issn
1437-4315journal_volume
382pub_type
杂志文章abstract::The 15 human kallikrein-related peptidases (KLKs) are clinically important biomarkers and therapeutic targets of interest in inflammation, cancer, and neurodegenerative disease. KLKs are secreted as inactive pro-forms (pro-KLKs) that are activated extracellularly by specific proteolytic release of their amino-terminal...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/hsz-2012-0249
更新日期:2013-01-01 00:00:00
abstract::Cysteine cathepsins are expressed in most tissues, including the gastrointestinal tract. We demonstrated an involvement of mouse intestinal cathepsin B in extracellular matrix remodeling for regeneration from trauma. The present study aimed at elucidating roles of cysteine cathepsins in the non-traumatized gastrointes...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/hsz-2014-0151
更新日期:2014-10-01 00:00:00
abstract::The albumin gene family arose in a series of duplication events which gave rise to symmetry in its structure. The four genes are tandemly linked on human chromosome 4q in the order: 5'ALB-5'AFP-5'ALF-5'DBP-centromere, and their introns display a symmetrical and repetitive pattern that is shared by members of the gene ...
journal_title:Biological chemistry
pub_type: 杂志文章
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abstract::Protein transport, especially into different cellular compartments, is a highly coordinated and regulated process. The molecular machineries which carry out these transport processes are highly complex in structure, function, and regulation. In the case of chloroplasts, thousands of protein molecules have been estimat...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2009.051
更新日期:2009-08-01 00:00:00
abstract::DNA-based immunization has been shown to induce protective immunity against several microbial pathogens including HIV-1. Several routes of DNA vaccination have been exploited. However, the properties of the immune responses seem to differ with the different routes used for DNA delivery, ultimately affecting the outcom...
journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:1999-03-01 00:00:00
abstract::The possible application of proteinase inhibitors in the support of anti-tumor chemotherapy requires profound knowledge of the proteinases involved in malignant processes. Therefore, the occurrence of cathepsins B, D, H, L and S and of gelatinases, urokinase plasminogen activator and stromelysins was studied in biopsi...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/bchm3.1996.377.11.695
更新日期:1996-11-01 00:00:00
abstract::We present a novel strategy, termed CISTEM, which allows direct in vivo screening of polypeptides displayed on the surface of E. coli cells by a combination of ligand-mediated protection and phage-mediated selection. The effectiveness of this new approach was demonstrated by displaying the T7.tag on the surface of E. ...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2001.202
更新日期:2001-12-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2020-11-26 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
abstract::Bone morphogenetic proteins (BMP) are dimeric factors initiating several distinct signaling cascades by binding to two types of transmembrane serine/threonine kinase receptors (BRI and BRII), and are thus regulating several steps in embryonal development and adult tissue homeostasis. BMP-2 contains two symmetrical pai...
journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2002.217
更新日期:2002-12-01 00:00:00
abstract::The Sialyl-Tn antigen (Sialyl alpha-Ser/Thr) is expressed as a cancer-associated antigen on the surface of cancer cells. Its presence is associated with a poor prognosis in patients with colorectal and other cancers. We previously reported that Sialyl-Tn expression in LSC human colon cancer cells could be explained by...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2001.029
更新日期:2001-02-01 00:00:00
abstract::Family with sequence similarity 134, Member B (FAM134B), is a cis-Golgi transmembrane protein that is known to be necessary for the long-term survival of nociceptive and autonomic ganglion neurons. Recent work has shown that FAM134B plays a pivotal role in autophagy-mediated turnover of endoplasmic reticulum (ER) memb...
journal_title:Biological chemistry
pub_type: 杂志文章
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更新日期:2019-03-26 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2003-05-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2001.195
更新日期:2001-11-01 00:00:00
abstract::Type I interferons (IFNs) produced primarily by plasmacytoid dendritic cells (pDCs) as part of the innate immune response to infectious agents induce the maturation of myeloid DCs and enhance antigen presentation. Type I IFNs also enhance apoptosis of virus-infected cells, stimulate cross priming and enhanced presenta...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2008-05-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2010.114
更新日期:2010-09-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2002.126
更新日期:2002-07-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
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journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2010.093
更新日期:2010-07-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization t...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/hsz-2013-0295
更新日期:2014-10-01 00:00:00
abstract::In mammals, betaine of the mitochondrial matrix is used in the cytosol by betaine-homocysteine S-methyltransferase for methionine synthesis. The resulting dimethylglycine is shuttled back into the mitochondrial matrix for further degradation. Nanospray tandem mass spectrometry and N-terminal amino acid sequencing of m...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2000.080
更新日期:2000-07-01 00:00:00
abstract::Major vault protein (MVP) is the predominant member of a large cytosolic ribonucleoprotein particle, termed vault. We have previously shown that MVP derived from electric ray electric organ becomes phosphorylated by protein kinase C in vitro and by tyrosine kinase in vivo. Here we show that MVP from two mammalian cell...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2001.180
更新日期:2001-10-01 00:00:00
abstract::Meprins are zinc-endopeptidases of the astacin family, which are expressed as membrane-bound or secreted forms in renal and intestinal brush-border membranes of mouse, rat and man. There are two types of meprin subunits, alpha and beta, which form disulfide-bonded homo- and heterodimers; further oligomerization is med...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2003.092
更新日期:2003-05-01 00:00:00
abstract::Malaria can be a very severe disease, particularly in young children, pregnant women (mostly in primipara), and malaria naïve adults, and currently ranks among the most prevalent infections in tropical and subtropical areas throughout the world. The widespread occurrence and the increased incidence of malaria in many ...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2001.069
更新日期:2001-04-01 00:00:00
abstract::The lysosomal cysteine proteinase cathepsin B has been implicated in the progression of various human tumors including ovarian cancer. Included in this study were 63 patients with epithelial ovarian carcinoma. Follow-up information (median follow-up period 7 years) was available for all patients, among whom 42 (66.7%)...
journal_title:Biological chemistry
pub_type: 杂志文章
doi:10.1515/BC.2002.146
更新日期:2002-07-01 00:00:00
abstract::Amphetamine ('Speed'), methamphetamine ('Ice') and its congener 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') are illicit drugs abused worldwide for their euphoric and stimulant effects. Despite compelling evidence for chronic MDMA neurotoxicity in animal models, the physiological consequences of such toxicity i...
journal_title:Biological chemistry
pub_type: 杂志文章,评审
doi:10.1515/BC.2011.016
更新日期:2011-01-01 00:00:00