Abstract:
:In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, the mechanism and the potential of the method with regard to overcoming physical limitations to gene delivery. Magnetic particle chemistry and physics are discussed, followed by a detailed presentation of vector formulation and optimization work. While magnetofection does not necessarily improve the overall performance of any given standard gene transfer method in vitro, its major potential lies in the extraordinarily rapid and efficient transfection at low vector doses and the possibility of remotely controlled vector targeting in vivo.
journal_name
Biol Chemjournal_title
Biological chemistryauthors
Plank C,Schillinger U,Scherer F,Bergemann C,Rémy JS,Krötz F,Anton M,Lausier J,Rosenecker Jdoi
10.1515/BC.2003.082keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
737-47issue
5eissn
1431-6730issn
1437-4315journal_volume
384pub_type
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