Abstract：
:Chaperonins mediate protein folding in an ATP-dependent manner. ATP binding and hydrolysis by chaperonins are subject to both homotropic and heterotropic allosteric regulation. In the case of GroEL and CCT, homotropic regulation by ATP is manifested in nested cooperativity, which involves positive intra-ring cooperativity and negative inter-ring cooperativity in ATP binding. Both types of cooperativity are modulated by various heterotropic allosteric effectors, which include nonfolded proteins, ADP, Mg2+, monovalent ions such as K+, and cochaperonins in the case of type I chaperonins such as GroEL. Here, the allosteric properties of chaperonins are reviewed and new results of ours are presented with regard to allosteric effects of ADP. The role of allostery in the reaction cycle and folding function of chaperonins is discussed.
journal_name
J Struct Bioljournal_title
Journal of structural biologyauthors
Horovitz A,Fridmann Y,Kafri G,Yifrach Odoi
10.1006/jsbi.2001.4377keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
104-14issue
2eissn
1047-8477issn
1095-8657pii
S1047-8477(01)94377-1journal_volume
135pub_type
杂志文章,评审abstract：:Uptake and metabolism of silicon by diatoms are studied by the combined use of solid-state 29Si NMR spectroscopy and confocal laser fluorescence microscopy especially with respect to the presence and nature of an intracellular silicon-storage pool. Cells of the marine diatom Thalassiosira pseudonana were synchronized ...
journal_title：Journal of structural biology
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journal_title：Journal of structural biology
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更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of structural biology
pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Journal of structural biology
pub_type： 杂志文章
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journal_title：Journal of structural biology
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pub_type： 杂志文章
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更新日期：1991-02-01 00:00:00
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journal_title：Journal of structural biology
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journal_title：Journal of structural biology
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更新日期：2010-06-01 00:00:00
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journal_title：Journal of structural biology
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journal_title：Journal of structural biology
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journal_title：Journal of structural biology
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更新日期：2010-09-01 00:00:00
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journal_title：Journal of structural biology
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abstract：:Cryo-electron tomography of vitreous sections is currently the most promising technique for visualizing arbitrary regions of eukaryotic cells or tissue at molecular resolution. Despite significant progress in the sample preparation techniques over the past few years, the three dimensional reconstruction using electron...
journal_title：Journal of structural biology
pub_type： 杂志文章
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