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Variation in human hair ultrastructure among three biogeographic populations.

Abstract：

:Human scalp hairs are often examined microscopically to study the variation and diversity among a range of visible morphological traits. In this study, we focused on the ultrastructure of human scalp hair within its keratinized matrix, emphasizing, the density and distribution of melanosomes, variation in cuticle thickness within populations, and the relationship of hair fiber ultrastructure with biogeographic ancestry. We used transmission electron microscopy (TEM) to visualize hair cross-sections and generate micron-scale resolution images for analysis of particle morphology and the layered hair matrix. Our results revealed considerable variation in all parameters examined, including the relationship of ultrastructure to biogeographic ancestry. Among the three metapopulations studied (European, African, and East Asian), we identified hair cross-sectional shape, cuticle dimensions, and melanosome distribution as traits that reveal statistically significant ancestry-related patterns. This study establishes trait patterns in hair morphology and ultrastructure among three biogeographically defined metapopulations to improve the current understanding of human variation in hair form and establish a foundation for future studies on the genetic and developmental bases of phenotypic variation in hair ultrastructure related to genotype.

journal_name

J Struct Biol

journal_title

Journal of structural biology

authors

Koch SL,Shriver MD,Jablonski NG

doi

10.1016/j.jsb.2018.11.008

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

60-66

issue

1

eissn

1047-8477

issn

1095-8657

pii

S1047-8477(18)30308-3

journal_volume

205

pub_type

杂志文章

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