Abstract：
OBJECTIVE:The aim of the present work was to study the association between HLA alleles and Takayasu's arteritis in Mexican Mestizo patients. METHODS:The study included 26 Mexican Mestizo patients with Takayasu's arteritis and 99 healthy unrelated individuals. HLA-A, -B and -DR alleles were determined by polymerase chain reaction PCR-SSP RESULTS: Increased gene frequencies were demonstrated for HLA-B15(p=0.009,pC=0.020,OR=3.24,EF=11.9%) and HLA-B52 (p=0.008, pC=0.027, OR=5.16, EF=7.7%), and a decreased frequency for the HLA-A24 allele in patients compared to normal controls (p=0.035, pC=NS, PF=11.1%). When HLA typing was correlated to clinicalfeatures in 24 cases, wefound an increasedfrequencies of HLA-DR14 in patients with systemic arterial hypertension (p=0.005, pC=0.004, OR=24.6, EF=38.3%) and HLA-A2 on patients with pulmonary involvement (p=0.034, pC=0.036, OR=3.67, EF=40.4%) when compared to patients without these clinical manifestations. CONCLUSION:These data confirm HLA-B52 as a relevant susceptibility allele for Takayasu's arteritis and suggest that HLA-B15 could be important as a marker of the disease in Mexican patients. Other class I and/or class II alleles could also be relevant as markers for the clinical features present in these patients.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Vargas-Alarcón G,Flores-Domínguez C,Hernández-Pacheco G,Zuñiga J,Gamboa R,Soto ME,Granados J,Reyes PAkeywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
439-43issue
4eissn
0392-856Xissn
1593-098Xjournal_volume
19pub_type
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2005-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2015-09-01 00:00:00
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