Abstract:
OBJECTIVES:To assess in daily practice in patients with rheumatoid arthritis (RA) the effect of treatment with first tumour necrosis factor-α inhibitor (TNFi) in quality of life (Qol), disease activity and depict possible baseline predictors for gains in Qol. METHODS:Patients followed prospectively by the Hellenic Registry of Biologic Therapies were analysed. Demographics were recorded at baseline, while RA-related characteristics at baseline and every 6 months. Paired t-tests were used to detect divergences between patient-reported (Health Assessment Questionnaire (HAQ), EuroQol (EQ-5D)) and clinical tools (Disease Activity Score-28 joints (DAS28)). Clinical versus self-reported outcomes were examined via cross-tabulation analysis. Multiple regression analysis was performed for identifying baseline predictors of improvements in QALYs. RESULTS:We analysed 255 patients (age (mean±SD) 57.1±13.0, disease duration 9.2±9.1 years, prior non-biologic disease-modifying anti-rheumatic drugs 2.3±1.2). Baseline EQ-5D, HAQ and DAS28 were 0.36 (0.28), 1.01 (0.72) and 5.9 (1.3), respectively, and were all significantly improved after 12 months (0.77 (0.35), 0.50 (0.66), 3.9 (1.5), respectively, p<0.05 for all). 90% of patients who improved from high to a lower DAS28 status (low-remission or moderate) had clinically important improvement in Qol (phi-coefficient=0.531,p<0.05). Independent predictors of gains in Qol were lower baseline HAQ, VAS global and younger age (adjusted R2=0.27). CONCLUSIONS:In daily practice TNFi improve both disease activity and Qol for the first 12 months of therapy. 90% of patients who improved from high to a lower DAS28 status had clinically important improvement in Qol. Younger patients starting with lower HAQ and VAS global are more likely to benefit.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Boubouchairopoulou N,Flouri I,Drosos AA,Boki K,Settas L,Zisopoulos D,Skopouli FN,Papadopoulos I,Iliopoulos A,Kyriopoulos J,Boumpas DT,Athanasakis K,Sidiropoulos Psubject
Has Abstractpub_date
2016-11-01 00:00:00pages
999-1005issue
6eissn
0392-856Xissn
1593-098Xpii
10426journal_volume
34pub_type
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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doi:
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doi:
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doi:
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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doi:
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