Abstract:
OBJECTIVES:The burden of depressive symptoms and how demographic and disease characteristics relate to depressive symptoms in patients with rheumatoid arthritis (RA) that belong to developing populations, are currently unknown and were therefore assessed in a case-control study in public healthcare patients in South Africa, a lower-middle income country. Public healthcare attendance is a surrogate of belonging to the developing population in South Africa. METHODS:Demographic and RA features were recorded in 441 public and 202 private healthcare patients. The outcome characteristic was the Arthritis Impact Measure Scales (AIMS) depression score. Relationships of patient characteristics and public healthcare attendance with depressive symptoms were determined in multivariable regression models. RESULTS:The mean ± SD AIMS depression score was 3.6±2.1 and 2.3±1.7 in public and private healthcare patients, respectively (p<0.0001 before and after adjustment for covariates). Physical disability was associated with depressive symptoms in both healthcare sectors. Other characteristics that were related to depressive symptoms comprised younger age, male sex and pain in public healthcare patients and fatigue and non-use of disease modifying agents in private healthcare patients. In all patients, public healthcare attendance (standardised ß [95% CI]=0.22 [0.12, 0.32], p<0.0001) and physical disability (standardised β [95% CI]=0.25 [0.16, 0.34], p<0.0001) were most strongly associated with depressive symptoms. CONCLUSIONS:The burden of depressive symptoms is markedly enhanced in our developing population with RA, independent of age, sex, ethnic origin and disease characteristics. In this setting, the role of social factors should be assessed and, despite restricted resources, depressive symptoms should be routinely addressed.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Solomon A,Christian BF,Woodiwiss AJ,Norton GR,Dessein PHsubject
Has Abstractpub_date
2011-05-01 00:00:00pages
506-12issue
3eissn
0392-856Xissn
1593-098Xpii
4218journal_volume
29pub_type
杂志文章abstract::The lysosomal endopeptidase cathepsin D is the most abundant proteinase in chondrocytes. Its significance in the pathogenesis of cartilage matrix proteoglycan (PG) degradation in osteoarthritis (OA) is unclear. The extracellular localization of cathepsin D and its potential spatial relationship to areas of PG depletio...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVES:Coeliac disease (CD) is a chronic autoimmune disease of the small intestine caused by the ingestion of gluten, in which musculoskeletal manifestations may occur. Aim of this study was to evaluate the prevalence and severity of joint involvement in paediatric patients with CD using musculoskeletal ultrasound ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To determine if quantitative hand images obtained from an office-based MRI extremity scanner reliably distinguish patients with rheumatoid arthritis from controls. METHODS:The hands of 39 patients suffering from rheumatoid arthritis were imaged using a small bore, 1.0 Tesla Magnetic Resonance Imager. Non-con...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:Superior vena cava syndrome (SVCS) is a medical emergency which can also be seen in Behçet's syndrome (BS). Having noted that BS patients with SVCS frequently complained of sleep disturbances, snoring and sleep apnea, suggesting obstructive sleep apnea (OSA), we formally surveyed the risk for OSA among BS pa...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2019-11-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2021-01-28 00:00:00
abstract::The antiperinuclear factor (APF) test is as sensitive and specific for rheumatoid arthritis as the classical rheumatoid factor tests. Five European laboratories decided to perform a consensus study on the interlaboratory variability of the APF test. They used different donor cells, different conjugates and different c...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Unprovoked activation of innate immune pathways and increased secretion of interleukin (IL)-1β and IL-18 are responsible for the protean clinical manifestations and the marked inflammatory response that characterise most hereditary autoinflammatory disorders. The kidney is a major target organ of this inflammatory pro...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2018-01-01 00:00:00
abstract::Histomorphological analysis of inflammatory lesions in rheumatoid arthritis (RA) and ankylosing spondylitis (AS) display similarities but also major differences. Ankylosing spondylitis is characterised by two key pathological findings: sacroiliac joint and spinal inflammation and new bone formation with the possible c...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:Recently, research has been focused on the identification of predictors of response to treatment in patients with active psoriatic arthritis (PsA). The objective of this study was to develop a model to predict the clinical response at 6 months in patients with PsA starting the anti-tumour necrosis factor-α g...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2020-01-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2019-09-01 00:00:00
abstract::Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15-30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflamma...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To determine the value of serial measurements of circulating cytokines in patients with rheumatoid arthritis in response to the introduction of disease modifying anti-rheumatic drugs (DMARDs). METHODS:A prospective 12-week study of 98 patients starting second line therapy with serial measurements of IL1 beta...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::In patients with SLE in remission pregnancy does not confer a special risk to either the mother or foetus, and immunoregulatory drugs should not be withdrawn prior to a pregnancy where these are required for disease control. Likewise therapy to treat disease flares during pregnancy should not be withheld as the foetus...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1988-04-01 00:00:00
abstract::There is a clear need to assess patients presenting with a new onset of inflammatory peripheral arthritis and/or back pain early. Indeed, the clinical presentation of rheumatoid arthritis (RA) is not always characteristic but its early diagnosis is crucial to prevent irreversible structural damage. Likewise low back p...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2018-11-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 临床试验,杂志文章
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVES:To examine the feasibility and efficacy of a multidisciplinary health care programme for patients with knee OA. METHODS:A 12-month follow-up care programme for knee OA, based on clinical evidence and expert opinion was implemented in primary care settings. It included recommendations on diagnosis, managemen...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To assess whether obesity and systemic inflammation are potential determinants of circulating adiponectin concentrations and whether low adiponectin levels cluster with metabolic syndrome features that are previously documented cardiovascular risk factors in rheumatoid arthritis (RA). METHODS:We investigated...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2008-07-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2020-09-01 00:00:00
abstract::The prevalence of antinuclear antibodies (ANA) was studied in 290 healthy adults, aged 20-88 years, and in 219 children, aged 1 month to 15 years. Two antigen substrates, rat liver tissue sections and HEp-2 cells, were compared at different serum dilutions. At titre 1/40, the number of positive adult samples was 6.9% ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract:OBJECTIVES:To evaluate early and late responses in biological-naïve patients with rheumatoid arthritis (RA) initiating tocilizumab and early tocilizumab non-responders who switched to rituximab. METHODS:In this open-label, non-randomised phase 3 study, RA patients with inadequate response to conventional synthetic DMA...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2019-11-01 00:00:00
abstract::Early arthritis is challenging because the clinical picture often does not allow a distinction between rheumatoid arthritis (RA), self-limiting disease, and other forms of inflammatory arthritis. In Germany the first early synovitis clinic and several inception cohorts of patients with early RA were initiated and eval...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:To study the health-related quality of life (HRQOL) in severe cryoglobulinaemic vasculitis (CV) associated with hepatitis C virus infection (HCV) and to describe the effect of rituximab on HRQOL. METHODS:HRQOL was evaluated with the Medical Outcomes Study Short Form 36 (SF-36). Health Survey questionnaire w...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::Alteration of the distribution pattern and composition of glycosaminoglycans (GAG) and proteoglycans may play an important role in the development of autoimmune diseases. Recent experiments indicate that anti-DNA antibodies cross-reacting with hyaluronic acid, heparan sulphate and chondroitin sulphate are present in p...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:Osteoarthritis (OA) is a common degenerative disease of the synovial joints. Although numerous studies have been performed, the aetiology of OA remains unclear. Evidence suggests that DNA methylation plays important roles in OA. METHODS:Integrated analysis of five gene expression and one methylation profili...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2017-11-01 00:00:00