Comparison of the quantitative measurement of 18F-FDG PET/CT and histopathological findings in IgG4-related disease.

Abstract:

OBJECTIVES:To investigate the utility of 18F-FDG PET/CT in the diagnostic procedure of IgG4-related disease (IgG4-RD), we analysed the association between quantitative method of 18F-FDG PET/CT and histological findings. METHODS:Twenty-one patients with IgG4-RD in whom 18F-FDG PET/CT was performed at the time of diagnosis were enrolled. Tissue biopsy was performed at 24 sites in 21 patients. To perform quantitative analysis of 18F-FDG PET/CT imaging, the highest standardised uptake value (SUV) of the pixels (SUVmax) and the average SUV (SUVmean) within the biopsied lesion were measured. The SUVmean of the liver was also measured as a reference. RESULTS:The mean age at diagnosis was 64.6±11.9 years, and the median serum IgG4 level was 650 mg/dl. Histological findings were consistent with IgG4-RD (histopathology-positive) at 19 out of 24 sites. Although there was no significant difference in the values of SUVmax between histopathology-positive and histopathology-negative tissues, the values of SUVmean were significantly higher in the histopathology-positive tissue (4.98 and 3.54, respectively p<0.05). The values of SUVmean/liver were also higher in the histopathology-positive tissue (2.17 and 1.52, respectively p<0.05). To establish a cut-off value of SUVmean to determine which of multiple lesions should be biopsied, a ROC curve was constructed. ROC curve analysis indicated SUVmean=4.07 or SUVmean/liver=1.66 as a cut-off value. CONCLUSIONS:Our present study suggested that quantitative analysis of 18F-FDG-PET/CT imaging might be useful for selecting the biopsy site in IgG4-RD. The calculation of SUVmean, not of SUVmax, is important for evaluating IgG4-RD-related lesions in 18F-FDG PET/CT imaging.

journal_name

Clin Exp Rheumatol

authors

Tsuji S,Iwamoto N,Horai Y,Fujikawa K,Fujita Y,Fukui S,Ideguchi R,Michitsuji T,Nishihata S,Okamoto M,Tsuji Y,Endo Y,Shimizu T,Sumiyoshi R,Koga T,Kawashiri SY,Igawa T,Ichinose K,Tamai M,Nakamura H,Origuchi T,Kudo

subject

Has Abstract

pub_date

2021-01-28 00:00:00

eissn

0392-856X

issn

1593-098X

pii

16288

pub_type

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