New insights in the pathogenesis and therapy of idiopathic recurrent pericarditis in children.

Abstract:

:Pericarditis has several different causes, however, in about 70% of paediatric patients, a specific aetiology cannot be detected and the pericarditis is considered idiopathic. Recurrences may occur in up to 15-30% of cases. The pathogenesis of recurrent disease is controversial. Infectious, autoimmune and autoinflammatory pathways have been proposed as mechanisms involved in recurrences. Therapeutic strategies are not standardised, non-steroidal anti-inflammatory drugs at high dosages being the mainstay of therapy with the possible addition of low dose colchicine to prevent recurrences. Biological agents are considered a possible new therapeutic frontiers in the care of idiopathic recurrent pericarditis.

journal_name

Clin Exp Rheumatol

authors

Gaspari S,Marsili M,Imazio M,Brucato A,Di Blasi Lo Cuccio C,Chiarelli F,Breda L

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

788-94

issue

5

eissn

0392-856X

issn

1593-098X

pii

6780

journal_volume

31

pub_type

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