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Digestive involvement in primary Sjögren's syndrome: analysis from the Sjögrenser registry.

Abstract：

OBJECTIVES:Digestive involvement (DI) has been reported in 10-30% of primary Sjögren's syndrome (pSS) patients, and few studies have systematically analysed the prevalence of DI in pSS patients. The aim of this study was to describe DI prevalence in pSS patients from the Sjögrenser Study, and to analyse its clinical associations. METHODS:All patients included in the Sjögrenser study, a Spanish multicentre randomised cohort, containing demographic, clinical and histologic data, have been analysed retrospectively. Patients were classified according to the presence of DI (oesophageal, gastric, intestinal, hepatic and pancreatic), and we have performed DI clinical associations, descriptive statistics, Student t or χ2 test, and uni and multivariate logistic regression. RESULTS:From 437 included patients, 95% were women, with a median age of 58 years, 71 (16.2%) presented DI: 21 (29.5%) chronic atrophic gastritis, 12 (16.9%) oesophageal motility dysfunction, 3 (4.2%) lymphocytic colitis, 18 (25.3%) primary biliary cholangitis, 15 (21.1%) autoimmune hepatitis, 7 (9.8%) pancreatic involvement and 5 (7%) coeliac disease. Half of them developed DI at the same time or after pSS diagnosis. Patients with DI were significantly older at pSS diagnosis (p=0.032), more frequently women (p=0.009), presented more autoimmune hypothyroidism and C3 hypocomplementaemia (p=0.040), and were treated more frequently with glucocorticoids, immunosuppressant and biologic therapies. Patients with pancreatic involvement presented more central nervous system and renal involvement, Raynaud's phenomenon, lymphoma and C3/C4 hypocomplementaemia. CONCLUSIONS:DI is frequent in Sjögrenser patients, mainly in the form of autoimmune disorders, and seem to be associated with a more severe phenotype. Our results suggest that DI should be evaluated in pSS patients, especially those with more severe disease.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Melchor S,Sánchez-Piedra C,Fernández Castro M,Andreu JL,Martínez Taboada V,Olivé A,Rosas J,Menor R,García-Aparicio Á,López Longo FJ,Manrique-Arija S,García Vadillo JA,López González R,Narváez J,Galisteo C,González Martín J

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

110-115

issue

eissn

0392-856X

issn

1593-098X

pii

16119

journal_volume

38 Suppl 126

pub_type

杂志文章,多中心研究

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Digestive involvement in primary Sjögren's syndrome: analysis from the Sjögrenser registry.