Abstract:
OBJECTIVES:There is no information on how patella cartilage relates to the radiological grade of individual features of patellofemoral osteoarthritis (osteophytes or joint space narrowing) which have been used in most epidemiological and clinical studies. In this study we compared patella cartilage volume as measured by magnetic resonance imaging (MRI) with radiological assessment of the patellofemoral joint. METHODS:157 subjects with specific features of patellofemoral osteoarthritis (osteophytes and joint space narrowing) ranging from grade 0-3 were examined (age 62 +/- 10 years, 62% female). Each subject had skyline and lateral patellofemoral radiographs performed. Patella cartilage volume was determined by processing images acquired in the sagittal plane using T1-weighted fat saturated MRI at an independent work station. RESULTS:Grade of joint space narrowing (JSN) as measured on skyline and lateral patellofemoral radiographs was inversely associated with patella cartilage volume. After adjusting for age, gender and body mass index, for every increase in grade of skyline JSN (0-3), the patella cartilage volume was reduced by 411 mm3. For every increase in lateral patellofemoral JSN grade (0-3), the adjusted patella cartilage volume was reduced by 125 mm3. The relationship was stronger for patella cartilage volume and skyline JSN (r = -0.54, p < 0.001) than for lateral patellofemoral JSN (r = -0.16, p = 0.015). There was no significant association between patella cartilage volume and osteophytes measured on skyline or lateral radiographs. CONCLUSIONS:There is a significant negative association between patella cartilage volume and JSN, but not osteophytes. This association was strongest for the skyline rather than lateral radiographs. Longitudinal studies will be needed to determine the role of patella cartilage measurement in assessing progression of patellofemoral osteoarthritis.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Cicuttini FM,Wang YY,Forbes A,Wluka AE,Glisson Mkeywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
321-6issue
3eissn
0392-856Xissn
1593-098Xjournal_volume
21pub_type
杂志文章abstract:OBJECTIVES:We sought to determine the prevalence and clinical and laboratory associations of fibromyalgia in adults with primary immunodeficiency (immunoglobulin (Ig) G subclass deficiency (IgGSD) and common variable immunodeficiency (CVID). METHODS:We performed a retrospective analysis of these observations in 300 no...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Selectively targeting signalling pathways represents a promising pharmacological approach in rheumatoid arthritis (RA). Abundant levels of epidermal growth factor receptor (EGFR) are expressed in the synovial lining layers, and the anti-arthritis effect of erlotinib and lapatinib, small-molecule EGFR tyrosin...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:The present study aimed to investigate the interactions among salivary S. mutans colonisation, serum mannose binding lectin level (MBL), oral ulcer activity and disease course in patients with Behçet's disease (BD). METHODS:One hundred and six BD patients, 25 patients with rheumatoid arthritis (RA) and 42 he...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:To estimate the number and costs of hospitalisations associated with osteoporosis in France. METHODS:Data for women aged 50 years and over were extracted from the 2008 French Hospital National Database. Criteria for acute care were established according to ICD-10 codes related to osteoporosis. As coding rul...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract::A 61-year-old woman, suffering from classic seropositive rheumatoid arthritis with rheumatoid nodule histologically documented, developed temporal arteritis. HLA-DR typing revealed the presence of DR3 and DR4 antigens. The findings from previous studies support the association of HLA-DR antigens, giant cell arteritis-...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVE:Synovial inflammation in rheumatoid arthritis (RA) leads to pannus tissue invasion and destruction of cartilage/bone matrix by proteinases. Our intention was to analyze some of the key matrix metalloproteinases (MMPs) in pannus tissue overlying evolving cartilage erosions in RA. METHODS:Frozen tissue samples...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:Digestive involvement (DI) has been reported in 10-30% of primary Sjögren's syndrome (pSS) patients, and few studies have systematically analysed the prevalence of DI in pSS patients. The aim of this study was to describe DI prevalence in pSS patients from the Sjögrenser Study, and to analyse its clinical as...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,多中心研究
doi:
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVES:Patients with clinically evident autoimmune disease are at increased risk for premature cardiovascular disease (CVD). Markers of serological autoimmunity such as anti-nuclear antibodies (ANA) are found in approximately 25% of the general population. Yet, the vast majority will not develop clinical autoimmune...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:Eosinophilic granulomatosis with polyangiitis (EGPA) is associated with an inflammation and the presence of antineutrophil cytoplasmic antibodies (ANCA). Thus, we investigated the impact of ANCAs and eosinophilic inflammation on neutrophil activation and extracellular traps (NETs) formation. METHODS:We recr...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2017-03-01 00:00:00
abstract::Ultrasound (US) has acquired an increasing role in the assessment of joint and periarticular abnormalities in osteoarthritis (OA). It is able to image a large set of abnormalities in this disease which include both inflammatory and structural changes at different peripheral joint sites and it is helpful in guiding loc...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2017-05-01 00:00:00
abstract::Cognitive functions were assessed in 12 elderly patients prior to and following a three-week therapeutic course of Naproxen, 750 mg/day. Four of the patients deteriorated in one of the four cognitive tests, one of these patients in two tests. However, none of these changes reached statistical significance. Although no...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVES:To analyse clinical severity/activity of rheumatoid arthritis (RA) according to smoking status. METHODS:The QUEST-RA multinational database reviews patients for Core Data Set measures including 28 swollen and tender joint count, physician global estimate, erythrocyte sedimentation rate (ESR), HAQ-function, ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:Osteoporosis is infrequent in young premenopausal women and is often associated with secondary disorders. However, idiopathic osteoporosis may be found in this setting and few data are known on this condition. Therefore, the aim of this study was to analyse the clinical characteristics and bone remodelling ab...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:Osteopontin (OPN) is a non-traditional pro-inflammatory cytokine and is involved in muscle regeneration and inflammation. The aim of this study was to investigate the expression of OPN in skeletal muscle and serum of patients with IIMs. METHODS:45 patients with IIMs (27 with PM and 18 with DM) were included...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:Fibromyalgia syndrome (FM) is an idiopathic chronic pain syndrome characterised by widespread nonarticular musculoskeletal pain, generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities, accompanied by a constellation of symptoms that include fatigue and disturban...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract::Surgical treatment of rheumatoid arthritis dates back some fifty years to when rheumatology developed into a separate branch of medicine. An interdisciplinary approach to rheumatoid arthritis was then introduced at a few specialized centres. By refining the surgical techniques, increasing the number of surgical option...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract::In this paper we report a 47 year old woman with septic arthritis due to Streptococcus pneumoniae. No known predisposing factor was found. After an extensive workup a multiple myeloma was discovered. In our case septic arthritis was the first manifestation of multiple myeloma. ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVES:To determine the preferred treatment for patients with Behçet's syndrome. METHODS:A questionnaire was given to all participants of the 2010 meeting of the International Society for Behçet's Disease. RESULTS:Forty-one respondents from 6 different subspecialties. In the case of a patient with (severe) poster...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:Rheumatoid arthritis (RA) is a chronic, devastating disease. Treat-to-target strategy (T2T) more than the usual care, reduces disease activity by using aggressively all therapeutic options. The aim of the study was to evaluate our hypothesis that T2T strategy using biologic disease-modifying anti-rheumatic d...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2017-03-01 00:00:00
abstract::Fibromyalgia syndrome (FMS) is a common form of non-inflammatory rheumatism within the general population with symptoms often mimicking those of arthritis or muscle disorders. Arthralgic symptoms in the region of the hip are commonly mentioned by patients with FMS and one of the diagnostic trigger points for the condi...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,多中心研究
doi:
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:To develop a standardized scoring system to assess the severity of DUs in SSc patients and correlate it with functional outcomes. METHODS:In this cross-sectional, longitudinal study in SSc patients with DUs (n=65) we developed a digital ulcers score (DUS) for the assessment of DUs. DUS and the ABILHAND scor...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:The present study was designed to investigate the effects of bindarit on animal survival and renal damage in murine lupus autoimmune disease. METHODS:Female NZB/W mice were used. Bindarit was administered, as a 0.5% medicated diet, starting either before the onset of the pathology or early in the course of t...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:Literature shows high rates of comorbidity between fibromyalgia (FM) and mood disorders, especially major depressive disorder (MMD), reported in more than half of the cases. Consistently, patients with FM also present high rates of mood spectrum symptoms, despite scant data are still available on the relatio...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2020-02-26 00:00:00
abstract:OBJECTIVE:Pulmonary involvement is a common finding in adults with systemic lupus erythematosus (SLE). The aim of this study was to investigate the frequency of pulmonary abnormalities in patients with childhood-onset SLE, with particular reference to interstitial lung disease (ILD), and to examine any association betw...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2006-03-01 00:00:00
abstract::We report on a patient with biopsy proven systemic Wegener's granulomatosis (WG) with a granulomatous necrotising manifestation of WG in the liver, lung, parotid gland and skin with subsequent death of liver failure. Liver involvement in WG is an exceedingly rare, though potentially fatal, organ manifestation of WG. ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Twenty-three per cent of rheumatoid arthritis (RA) patients show an increase of serum IgA concentrations. To determine the role of mucous-associated lymphoid tissue (MALT) in the elevation of serum IgA in RA, we studied the serum secretory-IgA (s-IgA) in 63 RA patients and in 30 healthy controls. We also analysed the ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVES:To investigate the in-situ expression of acetylcholinesterase (AChE) in the inflamed vessel wall of patients with biopsy-positive giant cell arteritis (GCA) as compared to biopsy-negative non-GCA patients, and to evaluate the in-vivo expression of AChE in patients with large-vessel GCA (LVGCA) by 11C-donepez...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:Coeliac disease (CD) is a chronic autoimmune disease of the small intestine caused by the ingestion of gluten, in which musculoskeletal manifestations may occur. Aim of this study was to evaluate the prevalence and severity of joint involvement in paediatric patients with CD using musculoskeletal ultrasound ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::Cyclooxygenase-2 (COX-2) selective inhibitors are now extensively used for their anti-inflammatory and analgesic efficacy. Several large controlled trials provide evidence to support the proposition that they cause fewer major gastro-intestinal side effects and less toxicity than routine nonsteroidal anti-inflammatory...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:A contribution of mast cells and its mediators in the pathogenesis of arthritis has been postulated. We aimed to clarify the role of mast cell-derived serine protease tryptase and proteinase activated receptor (PAR)-2-mediated signaling in chondrocytes. METHODS:Human articular cartilage specimens were obtain...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00