Abstract:
OBJECTIVES:The Schnitzler syndrome is a rare inflammatory disorder, with a chronic urticaria-like rash and an IgM (rarely IgG) monoclonal gammopathy as cardinal features. Interleukin-1 β is regarded as the key mediator and the interleukin-1 receptor antagonist anakinra has been proposed as first-line treatment. This case series of eleven patients is intended to enhance disease awareness and to compare our centre's experience with that of literature. METHODS:We describe the clinical features and disease course of 11 patients with a definite Schnitzler syndrome, according to the Strasbourg diagnostic criteria, encountered in the University Hospital, Leuven, Belgium, between 1995 and 2015. RESULTS:Eleven patients, with a median age of 55 years, were diagnosed with Schnitzler syndrome. All but one were diagnosed during the last decade. Of 6 patients treated with anakinra, 2 had a suboptimal response and 2 had poor tolerance (injection site reaction and neutropenia, respectively). Two of the 11 patients died as a consequence of the disease, culminating in Waldenström's macroglobulinaemia and AA amyloidosis, respectively. CONCLUSIONS:The Schnitzler syndrome is rare, but probably underdiagnosed. In a patient with a chronic urticaria-like dermatosis, minor itch, intermittent fever and bone or joint aches, protein electrophoresis and immunofixation should be ordered. Especially, a finding of a monoclonal IgM kappa fits the diagnosis of Schnitzler syndrome. Anakinra may provide symptomatic relief, although the response is not always spectacular. The outcome is not always benign as fatal complications may occur.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Vanderschueren S,van der Veen Asubject
Has Abstractpub_date
2017-01-01 00:00:00pages
69-73issue
1eissn
0392-856Xissn
1593-098Xpii
10598journal_volume
35pub_type
杂志文章abstract::A meta-analysis showed that methodological differences in prevalence studies such as a sample survey design or census design may be responsible for some of the variance in BS prevalence reported across countries, in addition to a true geographic variation. Efforts towards developing a data driven core set of outcome m...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental rheumatology
pub_type: 临床试验,杂志文章
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
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journal_title:Clinical and experimental rheumatology
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abstract:: ...
journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 传,历史文章,杂志文章
doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章
doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2019-11-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
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journal_title:Clinical and experimental rheumatology
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doi:
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