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Serum levels of tissue inhibitor of metalloproteinases in patients with mixed connective tissue disease.

Abstract：

OBJECTIVE:To determine serum tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 levels in patients with mixed connective tissue disease (MCTD) and investigate whether these levels were correlated with the clinical or serological features of this disease. METHODS:Serum TIMP-1 and TIMP-2 levels were measured with specific enzyme-linked immunosorbent assays. Serum samples from 26 patients with MCTD and 18 healthy individuals were examined. RESULTS; Serum levels of TIMP-1 were significantly higher in patients with MCTD than those in healthy individuals (mean +/- SD: 218.9 +/- 50.8 ng/ml versus 160.0 +/- 38.7 ng/ml, P < 0.0001). MCTD patients with elevated TIMP-1 had esophageal involvement at a significantly higher incidence than those without (77.8% versus 35.3%, p < 0.05). There was no difference in serum TIMP-2 levels between patients with MCTD and healthy controls (75.6 - 11.9 ng/ml versus 77.3 +/- 10.7 ng/ml). CONCLUSION:These results suggest that TIMP-1 is involved in the pathogenesis of MCTD, and that TIMP-1 may be a serological marker for the presence of esophageal involvement in these patients.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Jinnin M,Ihn H,Yamane K,Asano Y,Yazawa N,Tamaki K

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

539-42

issue

4

eissn

0392-856X

issn

1593-098X

journal_volume

20

pub_type

杂志文章

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