Abstract：
:Thrombotic microangiopathy (TMA) is a rare disorder characterized by microvascular thrombosis. TMA has been reported in patients with antiphospholipid antibodies and/or antiphospholipid syndrome but its pathogenesis is not clarified. We present two patients with TMA associated with IgG phosphatidylserine dependent antiprothrombin antibodies (aPS/PT). CASE 1: A 44-year-old Japanese female with systemic lupus erythematosus (SLE) and positive lupus anticoagulant (LA) was started on ticlopidine after having stroke. Four weeks later she developed TMA. IgG/M/A anticardiolipin antibodies (aCL) were negative, but strong positive IgG aPS/PT were detected. CASE 2: A 32-year-old Russian female with SLE was admitted because of hypertension, renal insufficiency and proteinuria at 14 weeks of pregnancy. She developed TMA after surgical abortion. IgG aPS/PT and LA were strongly positive but IgG/M/A aCL were negative. Neither case had von Willebrand factor cleaving protease (ADAMTS-13), suggesting that TMA in those patients was associated with thrombophilia rather than insufficient ADAMTS-13. Both patients were successfully treated with a series of plasma exchange.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Kon Y,Atsumi T,Hagiwara H,Furusaki A,Kataoka H,Horita T,Yasuda S,Amengual O,Takao Ksubject
Has Abstractpub_date
2008-01-01 00:00:00pages
129-32issue
1eissn
0392-856Xissn
1593-098Xpii
2258journal_volume
26pub_type
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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pub_type： 历史文章,杂志文章
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journal_title：Clinical and experimental rheumatology
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