当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL RHEUMATOLOGY期刊下所有文献 > Endothelial nitric oxide gene polymorphism and risk of systemic sclerosis: predisposition effect of T-786C promoter and protective effect of 27 bp repeats in Intron 4.

Endothelial nitric oxide gene polymorphism and risk of systemic sclerosis: predisposition effect of T-786C promoter and protective effect of 27 bp repeats in Intron 4.

Abstract：

OBJECTIVES:An impaired availability of nitric oxide (NO), related to polymorphisms in endothelial nitric oxide synthase (eNOS) gene, may influence the microvasculature in systemic Sclerosis (SSc). Three potential eNOS gene polymorphisms [tandem 27-bp repeats (VNTR) in intron 4, T786C in promoter region and G894T in exon 7] were investigated to affect the susceptibility to and the clinical course of SSc. METHODS:Fifty-nine patients with SSc (mean age 47,1+/-12,1 years) and 83 control subjects (mean age 41,1+/-12,8 years) were studied. Genotypes were determined through PCR with or without RFLP. RESULTS:Genotype distribution was significantly different between SSc patients and controls for intron 4aa (alleles for four repeats), genotype frequency being 3.4% and 17.1%, respectively (odds ratio for dominant effect, 0.35; 95% CI, 0.17 to 0.78; p=0.004). The CC genotype of the promoter was significantly high in frequency in the SSc patients (16.9%) compared to controls (7.3%) (odds ratio for dominant effect, 2.26; 95% CI: 1.14 to 4.48; p=0.020). CONCLUSIONS:Intron 4 aa genotype of eNOS gene is protective and homozygosity (CC) of T-786C promoter region is a risk factor for SSc in Turkish population. Our results highlight a possible mechanism by which a potential reduced availability of NO, related to VNTR in intron 4 and T-786C promoter polymorphism, may influence the predisposition to SSc.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Sinici I,Kalyoncu U,Karahan S,Kiraz S,Atalar E

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

169-75

issue

2

eissn

0392-856X

issn

1593-098X

pii

263

journal_volume

28

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY文献大全
  • Immunogenetics and clinical aspects of Takayasu's arteritis patients in a Mexican Mestizo population.

    abstract：OBJECTIVE:The aim of the present work was to study the association between HLA alleles and Takayasu's arteritis in Mexican Mestizo patients. METHODS:The study included 26 Mexican Mestizo patients with Takayasu's arteritis and 99 healthy unrelated individuals. HLA-A, -B and -DR alleles were determined by polymerase cha...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Vargas-Alarcón G,Flores-Domínguez C,Hernández-Pacheco G,Zuñiga J,Gamboa R,Soto ME,Granados J,Reyes PA

    更新日期：2001-07-01 00:00:00

  • Immunologic studies in patients with Takayasu's arteritis. II. Effects of serum on lymphocyte functions in vitro.

    abstract：:Natural lymphocytotoxic antibodies, circulating immune complexes and their effect on in vitro blast transformation of normal cells were studied in 24 patients with Takayasu's arteritis. Sera with Takayasu's arteritis lacked lymphocytotoxic antibodies, had an inhibitory effect on the formation of EA and EAC rosettes an...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Díaz-Jouanen E,Reyes PA,Frajman M,Llorente L,Sánchez-Torres G

    更新日期：1984-01-01 00:00:00

  • Premature ovarian failure in patients affected by systemic lupus erythematosus: a cross-sectional study.

    abstract：OBJECTIVES:We evaluated age at natural menopause and the prevalence of premature ovarian failure (POF) in a monocentric Caucasian cohort of patients with systemic lupus erythematosus (SLE). METHODS:In this cross-sectional study, we enrolled women affected by SLE compared with healthy controls (HC) to investigate data ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Ceccarelli F,Orefice V,Perrone G,Pirone C,Perricone C,Truglia S,Miranda F,Pacucci VA,Spinelli FR,Galoppi P,Alessandri C,Valesini G,Conti F

    更新日期：2020-05-01 00:00:00

  • Increased osteopontin in muscle and serum from patients with idiopathic inflammatory myopathies.

    abstract：OBJECTIVES:Osteopontin (OPN) is a non-traditional pro-inflammatory cytokine and is involved in muscle regeneration and inflammation. The aim of this study was to investigate the expression of OPN in skeletal muscle and serum of patients with IIMs. METHODS:45 patients with IIMs (27 with PM and 18 with DM) were included...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Xiao F,Tan JZ,Xu X,Zhu BL,Fang S,Wang XF

    更新日期：2015-05-01 00:00:00

  • The BeSt way of withdrawing biologic agents.

    abstract：OBJECTIVES:Treat-to-target strategies in the management of patients with rheumatoid arthritis (RA) involve intensifying medication as long as low disease activity or remission is not achieved. Our aim was to discuss reasons and opportunities for tapering and discontinuing medication when the target is achieved, in part...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：

    authors： Allaart CF,Lems WF,Huizinga TW

    更新日期：2013-07-01 00:00:00

  • Factors associated with damage in patients with familial Mediterranean fever.

    abstract：OBJECTIVES:Defining predictors of damage would improve patient care. We applied damage indexes to patients with familial Mediterranean fever (FMF) and identified the predictors of damage. METHODS:This is a cross-sectional analysis of 926 FMF patients, who fulfilled the Tel-Hashomer criteria and had at least six months...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Babaoglu H,Armagan B,Bodakci E,Satis H,Atas N,Sari A,Yasar Bilge NS,Bilici Salman R,Yardimci GK,Avanoglu Guler A,Karadeniz H,Kilic L,Ozturk MA,Goker B,Haznedaroglu S,Kalyoncu U,Kasifoglu T,Tufan A

    更新日期：2020-09-01 00:00:00

  • Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey.

    abstract：OBJECTIVE:It has been observed that familial Mediterranean fever is more prevalent among people coming from central Anatolia in Turkey. To test this observation the frequency of FMF was investigated by afield survey in Sivas, a city located in central of Turkey. METHODS:The survey was conducted in a cohort of 4809 per...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Onen F,Sumer H,Turkay S,Akyurek O,Tunca M,Ozdogan H

    更新日期：2004-07-01 00:00:00

  • Is quality of life affected by season and weather conditions in ankylosing spondylitis?

    abstract：OBJECTIVE:To examine the links between the quality of life (QOL) and season and weather conditions in ankylosing spondylitis (AS) patients. METHODS:A cohort of 146 AS patients (67% males), with a mean age of 47.3 years and a mean disease duration of 12.8 years, answered a self-administered questionnaire, the AS-AIMS2 ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Challier B,Urlacher F,Vançon G,Lemelle I,Pourel J,Guillemin F

    更新日期：2001-05-01 00:00:00

  • A comparison of the measurement properties and estimation of minimal important differences of the EQ-5D and SF-6D utility measures in patients with systemic sclerosis.

    abstract：OBJECTIVES:To compare measurement properties of the EQ-5D and SF-6D utility measures, to assess the association and agreement between these measures and to estimate minimal important differences (MID) in patients with systemic sclerosis (SSc). METHODS:Both measures were assessed twice in an observational prospective d...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Kwakkenbos L,Fransen J,Vonk MC,Becker ES,Jeurissen M,van den Hoogen FH,van den Ende CH

    更新日期：2013-03-01 00:00:00

  • Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of the variables indicative of disease activity and their use in the development of an activity sc

    abstract：:A European Consensus Group study, involving 29 centres from 14 countries, was performed in order to reach agreement on the definition of disease activity in systemic lupus erythematosus (SLE) and to construct a new disease index. Data on 704 lupus patients were collected and analysed, using univariate and multivariate...

    journal_title：Clinical and experimental rheumatology

    pub_type： 共识发展会议,杂志文章,多中心研究,评审

    doi：

    authors： Vitali C,Bencivelli W,Isenberg DA,Smolen JS,Snaith ML,Sciuto M,Neri R,Bombardieri S

    更新日期：1992-09-01 00:00:00

  • Serum interleukin 17 and interleukin 18 levels in familial Mediterranean fever.

    abstract：OBJECTIVE:Familial Mediterranean fever (FMF) attacks are characterized by serosal inflammation rich in PMNL leukocytes and activation of a definite cytokine network. Moreover, there is sustained inflammation in attack-free FMF patients. Interleukin (IL)-17 and IL-18 are recently described proinflammatory cytokines, whi...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Haznedaroglu S,Oztürk MA,Sancak B,Goker B,Onat AM,Bukan N,Ertenli I,Kiraz S,Calguneri M

    更新日期：2005-07-01 00:00:00

  • Treatment of Achilles tendon calcinosis in juvenile dermatomyositis with external ilizarov fixator.

    abstract：:Calcinosis is a devastating complication of juvenile dermatomyositis and a challenging therapeutic problem. We report the use of an external Ilizarov fixator for the treatment of Achilles tendon calcinosis causing severe disability in a young girl with juvenile dermatomyositis. ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Bilavsky E,Horesh Z,Amir J,Bar-On E,Harel L

    更新日期：2007-09-01 00:00:00

  • An immunochemical study of the synovial fluid can contribute to the distinction between rheumatoid and non rheumatoid arthritis.

    abstract：:Synovial fluids from 102 patients affected by various joint diseases have been analyzed for their protein, immunoglobulin and beta 2-microglobulin contents, for the total and alternative pathway hemolytic activities of the complement components, for the presence of rheumatoid factors and Clq binding materials. The aim...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Corvetta A,Ghirelli PA,Spaeth PJ,Orecchioni F,Galeazzi M,Sprovieri G,Butler R,Nydegger UE

    更新日期：1984-04-01 00:00:00

  • Clinical and immunomodulatory effects of fun-boi, an herbal medicine, on collagen-induced arthritis in vivo.

    abstract：OBJECTIVE:Crude preparations of Fun-boi (Stephania tetrandra), a traditional antirheumatic herb, have been reported to have immunomodulatory effects on both cell-mediated and humoral immunity in vitro, but little is known about the mode of action in vivo. The objective of this study was therefore to evaluate the effica...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Niizawa A,Kogure T,Hai LX,Fujinaga H,Takahashi K,Shimada Y,Terasawa K

    更新日期：2003-01-01 00:00:00

  • Anti-Saccharomyces cerevisiae antibodies--a novel serologic marker for Behçet's disease.

    abstract：OBJECTIVE:To evaluate the prevalence and clinical correlations of antibodies against Saccharomyces cerevisiae (ASCA) among patients with BD. METHODS:Twenty-seven BD patients were studied. Data from medical files and from patients' interviews was collected, regarding the entire spectrum of disease manifestations, and a...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Krause I,Monselise Y,Milo G,Weinberger A

    更新日期：2002-07-01 00:00:00

  • Pulmonary involvement in patients with childhood-onset systemic lupus erythematosus.

    abstract：OBJECTIVE:Pulmonary involvement is a common finding in adults with systemic lupus erythematosus (SLE). The aim of this study was to investigate the frequency of pulmonary abnormalities in patients with childhood-onset SLE, with particular reference to interstitial lung disease (ILD), and to examine any association betw...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Lilleby V,Aaløkken TM,Johansen B,Førre Ø

    更新日期：2006-03-01 00:00:00

  • Critical role of STIR MRI in early detection of post-streptococcal periostitis with dysproteinaemia (Goldbloom's syndrome).

    abstract：OBJECTIVES:In 1966, Goldbloom et al. described two children who developed a peculiar clinical picture characterized by intermittent daily bone pain in the lower limbs, fever spikes, increased acute phase reactants and dysproteinaemia. The syndrome occurred two weeks after a group A β-haemolytic streptococcus infection....

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Papa R,Consolaro A,Minoia F,Caorsi R,Magnano G,Gattorno M,Ravelli A,Picco P

    更新日期：2017-05-01 00:00:00

  • Osteonecrosis and bone infarction in association with Behcet's disease: report of two cases.

    abstract：:We describe two cases with Behcet's disease (BD) developing osteonecrosis or bone infarction. One patient developed the extensive bone infarction of the left knee without the use of corticosteroids. The other patient had osteonecrosis at the right femoral head. He had had a past history of significant corticosteroid a...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Chang HK,Choi YJ,Baek SK,Lee DH,Won KS

    更新日期：2001-09-01 00:00:00

  • Abatacept therapy reduces CD28+CXCR5+ follicular helper-like T cells in patients with rheumatoid arthritis.

    abstract：OBJECTIVES:The characteristics of T cells targeted by abatacept (ABT) in cases of rheumatoid arthritis (RA) are still unknown. The goal of the study was to determine the pathogenicity of T cells and the predictors of therapeutic effects of ABT. METHODS:We analysed the peripheral T cell phenotype of 34 RA patients via ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Fukuyo S,Nakayamada S,Iwata S,Kubo S,Saito K,Tanaka Y

    更新日期：2017-07-01 00:00:00

  • Ten-year follow up study of patients from a Yersinia pseudotuberculosis III outbreak.

    abstract：:A Yersinia pseudotuberculosis serotype III outbreak in 1982 was characterized by a high frequency of post-infectious complications. Ten years later 16 out of the 19 patients originally included in the outbreak were reached for a follow up evaluation. Altogether nine patients suffered from chronic joint symptoms. Four ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Yli-Kerttula T,Tertti R,Toivanen A

    更新日期：1995-05-01 00:00:00

  • Assessment of the joint recesses and tendon sheaths in healthy children by high-resolution B-mode and power Doppler sonography.

    abstract：OBJECTIVE:To describe or determine reference values for the intracapsular cavity and its joint recess of the hip, knee and joints of the hand and for the tendon sheaths of fingers, examined with B-mode gray-scale ultrasonography (US) and power Doppler (PD) in healthy children. METHODS:Sixty healthy children (31 boys a...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Collado P,Naredo E,Calvo C,Crespo M

    更新日期：2007-11-01 00:00:00

  • Reliability of ultrasound measurements of dermal thickness at digits in systemic sclerosis: role of elastosonography.

    abstract：OBJECTIVES:To investigate the role of elastosonography to improve the reliability of the ultrasound in the measurement of the dermal thickness at finger level in systemic sclerosis (SSc). METHODS:Twenty-two patients with a diagnosis of SSc were consecutively recruited. In all patients at the second finger level of the...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Di Geso L,Filippucci E,Girolimetti R,Tardella M,Gutierrez M,De Angelis R,Salaffi F,Grassi W

    更新日期：2011-11-01 00:00:00

  • Cervical spine involvement in longstanding ankylosing spondylitis.

    abstract：OBJECTIVE:To investigate the degree of ossification and the frequency of ankylosis between the atlas and the dens of the axis in patients with longstanding ankylosing spondylitis (AS), to assess radiological involvement of the cervical spine, and to determine their correlations with structural severity and clinical var...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Lee JY,Kim JI,Park JY,Choe JY,Kim CG,Chung SH,Lee DK,Chang HK

    更新日期：2005-05-01 00:00:00

  • Protease inhibitors in rheumatoid synovial fluid: a quantitative analysis.

    abstract：:The concentrations of the main endogenous inhibitors of granulocyte proteases (anti-leukoprotease, alpha 1-antitrypsin, alpha 1-antichymotrypsin, and alpha 2-macroglobulin) were estimated in paired samples of synovial fluid and serum/plasma from seropositive rheumatoid arthritics and controls. Rheumatoid synovial flui...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Ekerot L,Sjöblom KG,Ohlsson K,Wollheim FA

    更新日期：1983-07-01 00:00:00

  • Evaluation of third generation anti-CCP antibodies in the diagnosis of rheumatoid arthritis from undifferentiated polyarthritis after 4 years of follow-up.

    abstract：OBJECTIVES:Rheumatoid arthritis (RA) is a complex pathology to identify at an early stage. A large number of patients with recent onset polyarthritis (ROP) do not usually fulfil the ACR criteria for diagnosis of the disease and are classified as having undifferentiated polyarthritis. The aim of this study is to verify ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Caro-Oleas JL,Fernández-Suárez A,Reneses Cesteros S,Porrino C,Núñez-Roldán A,Wichmann Schlipf I

    更新日期：2008-05-01 00:00:00

  • Challenges in defining and improving osteoporosis quality of care.

    abstract：:Osteoporosis diagnosis and treatment are commonly overlooked by primary care providers and patients, leading to significant morbidity, mortality and unnecessary health care costs. Fewer than 20% of patients receive screening or treatment for osteoporosis following fragility fractures. In addition, bone density screeni...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Warriner A,Curtis JR,Saag KG

    更新日期：2007-11-01 00:00:00

  • Comparison between patella cartilage volume and radiological assessment of the patellofemoral joint.

    abstract：OBJECTIVES:There is no information on how patella cartilage relates to the radiological grade of individual features of patellofemoral osteoarthritis (osteophytes or joint space narrowing) which have been used in most epidemiological and clinical studies. In this study we compared patella cartilage volume as measured b...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Cicuttini FM,Wang YY,Forbes A,Wluka AE,Glisson M

    更新日期：2003-05-01 00:00:00

  • Intravenous immunoglobulins in polyarteritis nodosa restricted to the limbs: case reports and review of the literature.

    abstract：:Polyarteritis nodosa (PAN) of the calf muscles is a rare form of vasculitis. We present two cases of PAN limited to the calf and a review of the literature, based on a MEDLINE (PubMed) search of the English literature from 1980 to 2005, using the key words "vasculitis restricted to limbs", "polyarteritis nodosa", and ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Balbir-Gurman A,Nahir AM,Braun-Moscovici Y

    更新日期：2007-01-01 00:00:00

  • Yersinia enterocolitica leads to transient induction of TNF-alpha and activates NF-kappaB in synovial fibroblasts.

    abstract：OBJECTIVE:The importance of the presence of bacterial antigen or even living bacteria for the pathogenesis of reactive arthritis has been discussed increasingly ever since bacterial antigen was found in inflamed joints. Bacteria may persist in the body and drive the local immune response, maintaining arthritis. Cytokin...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Meyer-Bahlburg A,Greil S,Kruse N,Marienfeld R,Serfling E,Huppertz HI

    更新日期：2004-05-01 00:00:00

  • Relative value of commercial kits for ANA testing.

    abstract：AIMS:We have tested the relative performance of 20 commercial ANA test kits along with that of our own laboratory to assess whether one was clearly superior. METHODS:The sera were drawn from 3 pools that had all been pre-tested in our laboratory: patients with definite SLE; patients with non-connective tissue diseases...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Russell AS,Johnston C

    更新日期：2003-07-01 00:00:00