当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL RHEUMATOLOGY期刊下所有文献 > Th17 gene expression in psoriatic arthritis synovial fluid and peripheral blood compared to osteoarthritis and cutaneous psoriasis.

Th17 gene expression in psoriatic arthritis synovial fluid and peripheral blood compared to osteoarthritis and cutaneous psoriasis.

Abstract：

OBJECTIVES:The IL-23/IL-17 axis is central to the pathogenesis of psoriatic arthritis (PsA). We aimed to identify Th17 signalling genes that are dysregulated in synovial fluid of PsA compared to osteoarthritis (OA) patients and to determine if differences in peripheral blood can distinguish PsA from psoriasis patients and controls. METHODS:Synovial fluid cells (SFCs) from 14 PsA and 9 OA patients were obtained and stored in TRIzol reagent. RNA was isolated by phenol-chloroform extraction and purified with RNeasy miniprep kits. Total RNA was extracted from PAXgene whole blood from 20 PsA, 20 psoriasis without arthritis (PsC) and 11 controls. Quantitative RT-PCR arrays were used to profile expression of 84 genes related to the Th17 regulatory network. Fold change differences were compared by Mann-Whitney U-test with false discovery rate (FDR) correction (FDR<0.05). RESULTS:In PsA compared to OA SFCs, a total of 33 genes were up-regulated and 27 genes were down-regulated. Signalling molecules (such as STAT3, FOXP3) were highly expressed in PsA SFCs, while cytokines (such as IL17F, IL6) were more predominant in OA SFCs after non-supervised hierarchal clustering. Nine genes (MMP3, CCL1, IL17C, CCL20, IL17F, IL3, CXCL5, IL6 and CX3CL1) had concordant expression in SFCs and in peripheral blood cells (PBCs) of PsA compared to PsC and/or controls. CONCLUSIONS:We identified expression differences in Th17 signalling genes in PsA compared to OA SFCs, with an elevation of signalling molecules and attenuation of cytokine expression in PsA. A subset of genes was concordant in PBCs; these may thus be potential biomarkers of PsA.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Abji F,Pollock RA,Liang K,Chandran V,Gladman DD

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

486-489

issue

3

eissn

0392-856X

issn

1593-098X

pii

11726

journal_volume

36

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY文献大全
  • Clinical significance of coexisting antitopoisomerase I and anticentromere antibodies in patients with systemic sclerosis: a EUSTAR group-based study.

    abstract：OBJECTIVES:To determine the clinical characteristics of simultaneous occurrence of antitopoisomerase (ATA) and anticentromere (ACA) autoantibodies in systemic sclerosis (SSc). METHODS:Data of patients (n=4,687) fulfilling the ACR criteria for SSc and followed in the EULAR Scleroderma Trials and Research (EUSTAR) cohor...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Heijnen IA,Foocharoen C,Bannert B,Carreira PE,Caporali R,Smith V,Kumánovics G,Becker MO,Vanthuyne M,Simsek I,Bocelli-Tyndall C,Walker UA

    更新日期：2013-03-01 00:00:00

  • Endothelial nitric oxide gene polymorphism and risk of systemic sclerosis: predisposition effect of T-786C promoter and protective effect of 27 bp repeats in Intron 4.

    abstract：OBJECTIVES:An impaired availability of nitric oxide (NO), related to polymorphisms in endothelial nitric oxide synthase (eNOS) gene, may influence the microvasculature in systemic Sclerosis (SSc). Three potential eNOS gene polymorphisms [tandem 27-bp repeats (VNTR) in intron 4, T786C in promoter region and G894T in exo...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Sinici I,Kalyoncu U,Karahan S,Kiraz S,Atalar E

    更新日期：2010-03-01 00:00:00

  • Chronic recurrent multifocal osteomyelitis presenting with Tolosa-Hunt syndrome in a 13-year-old boy.

    abstract：: ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 信件

    doi：

    authors： Torreggiani S,Cinnante CM,Torcoletti M,Corona F,Agostoni C,Filocamo G

    更新日期：2017-05-01 00:00:00

  • Tenosynovitis due to Mycobacterium avium-intracellulare: case report and a review of the literature.

    abstract：:A 57-year-old female patient presented with a tenosynovitis due to Mycobacterium avium-intracellulare (MAI). A relapse occurred following surgical treatment, after which she was successfully treated with ansamycin and ethambutol. Previously reported cases of tenosynovitis due to MAI are reviewed and the treatment moda...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Eggelmeijer F,Kroon FP,Zeeman RJ,Dijkmans BA,van 't Wout JW

    更新日期：1992-03-01 00:00:00

  • Association of salivary S. mutans colonisation and mannose-binding lectin deficiency with gender in Behçet's disease.

    abstract：OBJECTIVE:The present study aimed to investigate the interactions among salivary S. mutans colonisation, serum mannose binding lectin level (MBL), oral ulcer activity and disease course in patients with Behçet's disease (BD). METHODS:One hundred and six BD patients, 25 patients with rheumatoid arthritis (RA) and 42 he...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Mumcu G,Inanc N,Aydin SZ,Ergun T,Direskeneli H

    更新日期：2009-03-01 00:00:00

  • Epilepsy in systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) is an autoimmune systemic disease characterised by a broad spectrum of clinical manifestations that may also affect the central nervous system. Among the neurological symptoms, seizures were included in the criteria for the classification of SLE published by EULAR/ACR in 2019. Severa...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Grasso EA,Cacciatore M,Gentile C,Breda L,Giacomelli R,Verrotti A

    更新日期：2020-09-04 00:00:00

  • The frequency of Leu 1+B cells in autoantibody positive and negative autoimmune diseases and in neonatal cord blood.

    abstract：:There is increasing evidence supporting the involvement of Leu 1+B cells in the development of human autoimmune diseases. In this study, the frequency of Leu 1+B cells has been analysed by a multiparameter FACS machine in newborn cord blood, and in the peripheral blood of several autoimmune patients and their healthy ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Kazbay K,Osterland CK

    更新日期：1990-05-01 00:00:00

  • Glucocorticoids in rheumatology: indications and routes of administration.

    abstract：:This paper in short reviews general indications, doses and routes of administration of glucocorticoid therapy in rheumatology. It presents greater detail concerning intralesional and intra-articular glucocorticoid injections. ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Jacobs JW,Bijlsma JW

    更新日期：2011-09-01 00:00:00

  • Comparison of F18-FDG PET/CT findings with current clinical disease status in patients with Takayasu's arteritis.

    abstract：OBJECTIVES:18F-fluorodeoxyglucose-positron emission tomography/computed tomography (F-18 FDG PET/CT) scanning has been proposed as a new tool to assess disease activity in Takayasu Arteritis (TA). We investigated whether F-18 FDG PET/CT findings were consistent with current clinical disease status in patients with TA. ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Karapolat I,Kalfa M,Keser G,Yalçin M,Inal V,Kumanlioğlu K,Pirildar T,Aksu K

    更新日期：2013-01-01 00:00:00

  • Features of repeated muscle biopsies and phenotypes of monocytes in paired blood samples and clinical long-term response to treatment in patients with idiopathic inflammatory myopathy: a pilot study.

    abstract：OBJECTIVES:In a pilot study we aimed to identify biomarkers in repeated muscle biopsies and paired blood samples, taken before and after conventional immunosuppressive therapy, in order to predict long-term therapeutic response in patients with idiopathic inflammatory myopathies (IIM). METHODS:Muscle biopsies were sel...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Tang Q,Gheorghe KR,Zhang XM,Lindroos E,Alexanderson H,Wick C,Bruton M,Fernandes-Cerqueira C,Harris RA,Nennesmo I,Lundberg IE

    更新日期：2020-01-01 00:00:00

  • Association between vascular cell adhesion molecule 1 and radiographic hand osteoarthritis.

    abstract：BACKGROUND:A recent study showed that the level of soluble Vascular Cell Adhesion Molecule 1 (VCAM-1) emerged as a strong and independent predictor of the risk of hip and knee joint replacement due to severe osteoarthritis (OA). Therefore, we hypothesized that soluble VCAM-1 level can be associated with prevalence and ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Kalichman L,Pantsulaia I,Kobyliansky E

    更新日期：2011-05-01 00:00:00

  • Long-term follow-up of technetium articular index in rheumatoid arthritis patients during oral chrysotherapy: evidence of paradoxical behaviour.

    abstract：:The Technetium Articular Index (TcAI) is regarded as a parameter of local inflammation in rheumatoid arthritis (RA). We studied TcAI behaviour during 1-year chrysotherapy in a group of fifteen RA patients. In non-responders TcAI showed a gradual decrease up to the 6th month and a return to baseline values within the s...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Mathieu A,Pala R,Satta L,Piga M

    更新日期：1988-01-01 00:00:00

  • An identical twin pair discordant for rheumatoid arthritis and ankylosing spondylitis.

    abstract：:Both rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have an increased familial occurrence and each disease is associated with the inheritance of specific HLA antigens. We report a pair of identical twin brothers with discordant disease phenotypes: one developed AS at the age of 26, and the other developed R...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： MacGregor AJ,Fox H,Ollier WE,Snaith ML,Silman AJ

    更新日期：1993-07-01 00:00:00

  • Adverse events and infections in patients with rheumatoid arthritis treated with conventional drugs or biologic agents: a real world study.

    abstract：OBJECTIVES:Treatment of rheumatoid arthritis (RA) with disease-modifying anti-rheumatic drugs (DMARDs), either synthetic (sDMARDs) or biologic agents (bDMARDs) has significantly improved disease outcome. However, the impact of therapy-related adverse events (AEs), mild, moderate or serious, on disease outcome is under ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Lampropoulos CE,Orfanos P,Bournia VK,Karatsourakis T,Mavragani C,Pikazis D,Manoussakis MN,Tzioufas AG,Moutsopoulos HM,Vlachoyiannopoulos PG

    更新日期：2015-03-01 00:00:00

  • Current approach to the management of psoriatic arthritis according to a sample of Italian rheumatologists.

    abstract：OBJECTIVES:The purpose of this study was to have an overview of the current approach to psoriatic arthritis (PsA) by a group of Italian rheumatologists. METHODS:Rheumatologists from all around Italy were asked to participate in a survey to give their opinion on a number of statements made by a panel of rheumatologists...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Marchesoni A,Lubrano E,Manara M,Ramonda R,Salvarani C,Olivieri I

    更新日期：2016-11-01 00:00:00

  • Tocilizumab in the treatment of patients with rheumatoid arthritis in real clinical practice: results of an Italian observational study.

    abstract：OBJECTIVES:To describe the effectiveness and safety of tocilizumab (TCZ), an interleukin-6 receptor inhibitor, in a cohort of patients with rheumatoid arthritis (RA) recruited in clinical practice. METHODS:TRUST was an observational study in RA patients who started treatment with TCZ in the 6 months prior to site acti...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,多中心研究

    doi：

    authors： Caporali R,Idolazzi L,Bombardieri S,Ferraccioli G,Gerli R,Govoni M,Matucci Cerinic M,Pomponio G,Salaffi F,Tirri R,Benaglio F,Bianchino L,Sarzi-Puttini P,TRUST study investigators.

    更新日期：2017-11-01 00:00:00

  • Cutaneous manifestations of primary Sjögren's syndrome are underestimated.

    abstract：:The association of kerato-conjunctivitis sicca and xerostomia has been termed Sjogren's syndrome (SS). Although this disease is referred to as a non-organ-specific autoimmune condition, the vast majority of the deleterious effects of primary SS are restricted to the exocrine glands. Among them, the lacrymal and saliva...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Roguedas AM,Misery L,Sassolas B,Le Masson G,Pennec YL,Youinou P

    更新日期：2004-09-01 00:00:00

  • Histologic assessment of cathepsin D in osteoarthritic cartilage.

    abstract：:The lysosomal endopeptidase cathepsin D is the most abundant proteinase in chondrocytes. Its significance in the pathogenesis of cartilage matrix proteoglycan (PG) degradation in osteoarthritis (OA) is unclear. The extracellular localization of cathepsin D and its potential spatial relationship to areas of PG depletio...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Vittorio N,Crissman JD,Hopson CN,Herman JH

    更新日期：1986-07-01 00:00:00

  • Acinar adipose tissue infiltration in salivary gland biopsy is associated with kynurenines-Interferon-γ pathway inflammation biomarkers.

    abstract：OBJECTIVES:Assess if kynurenines metabolites are biomarkers of damage at labial salivary gland biopsy (LSGB). METHODS:This is a cross-sectional study including 99 patients with primary Sjögren's syndrome (AECG 2002 or ACR/EULAR 2017). Kynurenines were measured in plasma using liquid chromatography-tandem mass spectrom...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Sardenberg WM,Santos MCLFS,Skarstein K,Carvalho Caser L,Brun JG,Ulvik A,Ueland PM,Mydel PM,Jonsson R,Valim V

    更新日期：2020-07-01 00:00:00

  • Unusual association between pure red cell aplasia and primary Sjögren's syndrome: a case report.

    abstract：:Pure red cell aplasia (PRCA) is an acute anemia due to selective suppression of erythropoiesis. We report a case of PRCA diagnosed before the onset of primary Sjögren's syndrome (SS). A young woman, with autoimmune thyroiditis, developed polyarthritis with ANA and Rheumatoid factor positivity, diagnosed as Rheumatoid ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Cavazzana I,Ceribelli A,Franceschini F,Cattaneo R

    更新日期：2007-03-01 00:00:00

  • Vasculitides secondary to infections.

    abstract：:Many viruses can be responsible for systemic vasculitis, the most frequent being hepatitis B virus-related polyarteritis nodosa (HBV-PAN), even though its incidence has decreased over the past few decades. Mixed cryoglobulinemia has been shown to be associated with hepatitis C virus (HCV) infection in more than 80% of...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章,评审

    doi：

    authors： Pagnoux C,Cohen P,Guillevin L

    更新日期：2006-03-01 00:00:00

  • IL-8 producing cells in patients with Behçet's disease.

    abstract：OBJECTIVE:IL-8 is thought to be the principal chemokine responsible for neutrophil activation and tissue infiltration in patients with Behçet's disease (BD). In various studies serum levels of IL-8 were reported to be increased. METHODS:IL-8 mRNA was purified from both peripheral whole blood samples and separated lymp...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Mantas C,Direskeneli H,Oz D,Yavuz S,Akoglu T

    更新日期：2000-03-01 00:00:00

  • Abatacept therapy reduces CD28+CXCR5+ follicular helper-like T cells in patients with rheumatoid arthritis.

    abstract：OBJECTIVES:The characteristics of T cells targeted by abatacept (ABT) in cases of rheumatoid arthritis (RA) are still unknown. The goal of the study was to determine the pathogenicity of T cells and the predictors of therapeutic effects of ABT. METHODS:We analysed the peripheral T cell phenotype of 34 RA patients via ...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Fukuyo S,Nakayamada S,Iwata S,Kubo S,Saito K,Tanaka Y

    更新日期：2017-07-01 00:00:00

  • Cardiac involvement of Churg Strauss syndrome demonstrated by magnetic resonance imaging.

    abstract：:Churg Strauss syndrome (CSS) may lead to cardiac involvement in up to 60% of patients. The myocardium, coronary vasculature, valves and pericardium may be affected. This results in significant morbidity and mortality, accounting for 48% of deaths due to CSS. Cardiac magnetic resonance imaging (CMR) is used to evaluate...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Smedema JP,van Paassen P,van Kroonenburgh MJ,Snoep G,Crijns HJ,Tervaert JW

    更新日期：2004-01-01 00:00:00

  • Brazil Patient Knowledge Questionnaire (PKQ) and evaluation of disease-specific knowledge in patients with rheumatoid arthritis.

    abstract：OBJECTIVE:To create a Brazilian version of the Patient Knowledge Questionnaire--PKQ, an instrument for measuring the knowledge of patients with rheumatoid arthritis (RA) as regards their disease, and through the use of this instrument, also measure the knowledge of RA patients from reference hospitals in the city of Sã...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Jennings F,Toffolo S,de Assis MR,Natour J

    更新日期：2006-09-01 00:00:00

  • Rheumatoid arthritis patients with low baseline Health Assessment Questionnaire scores have a risk of functional disability progression: a post hoc analysis of a nationwide longitudinal cohort in Japan.

    abstract：OBJECTIVES:To determine prognostic factors for the Health Assessment Questionnaire-Disability Index (HAQ-DI) progression in patients with rheumatoid arthritis (RA) in clinical practice. METHODS:We evaluated 388 biological disease-modifying anti-rheumatic drug (bDMARD)-naïve Japanese patients with RA with moderate to h...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Sumiyoshi R,Hidaka T,Koga T,Okada A,Fukuda T,Ishii T,Ueki Y,Kodera T,Nakashima M,Takahashi Y,Honda S,Horai Y,Watanabe R,Okuno H,Aramaki T,Izumiyama T,Takai O,Miyashita T,Kawashiri SY,Iwamoto N,Ichinose K,Tamai M

    更新日期：2020-11-01 00:00:00

  • Induction of psoriatic skin lesions in a patient with rheumatoid arthritis treated with rituximab.

    abstract：:Rituximab is a chimeric monoclonal therapeutic antibody which causes depletion of CD20-positive B cells. Apart from its apparent efficacy in the treatment of non-Hodgkin lymphoma and of several rheumatic diseases, it is associated with adverse events including the induction of autoimmune phenomena. We describe here th...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Markatseli TE,Kaltsonoudis ES,Voulgari PV,Zioga A,Drosos AA

    更新日期：2009-11-01 00:00:00

  • Ultrasound assessment of the posterior sacroiliac ligaments.

    abstract：OBJECTIVES:Posterior ligaments of the sacroiliac joints (SIJ) are comprised of the long and the short posterior sacroiliac ligaments. They are recognised as a potential source of aspecific low back pain or peripartum pelvic pain. The aim of this study was to assess the characteristics of these ligaments using high reso...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Le Goff B,Berthelot JM,Maugars Y

    更新日期：2011-11-01 00:00:00

  • Impaired expression of erythrocyte glycosyl-phosphatidylinositol-anchored membrane CD59 in patients with psoriatic arthritis. Relation to terminal complement pathway activation.

    abstract：OBJECTIVE:Complement-mediated injury is regulated by many factors; among these CD59 has been identified as a widely distributed glycoprotein that inhibits membrane C5b-9 (terminal complement component) formation. The aim of the study was to assess erythrocyte CD59 expression in patients with psoriatic arthritis in orde...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Triolo G,Accardo-Palumbo A,Sallì L,Ciccia F,Ferrante A,Tedesco L,Sallì S,Giardina E,Pappalardo A,Licata G

    更新日期：2003-03-01 00:00:00

  • IL-1-mediated expression of membrane type matrix-metalloproteinase in rheumatoid osteoblasts.

    abstract：OBJECTIVE:To determine whether the activation of metalloproteinases can be achieved by the interaction of the inflammatory cytokine, IL-1 beta, with rheumatoid osteoblasts. RESULTS:MMP-2 is not secreted by rheumatoid osteoblasts as a proenzyme; however, IL-1 beta stimulation induced the secretion of MMP-2 as an active...

    journal_title：Clinical and experimental rheumatology

    pub_type： 杂志文章

    doi：

    authors： Origuchi T,Migita K,Nakashima T,Tominaga M,Nakamura H,Nakashima M,Aoyagi T,Kawakami A,Kawabe Y,Eguchi K

    更新日期：2000-05-01 00:00:00