Induction of psoriatic skin lesions in a patient with rheumatoid arthritis treated with rituximab.

Abstract:

:Rituximab is a chimeric monoclonal therapeutic antibody which causes depletion of CD20-positive B cells. Apart from its apparent efficacy in the treatment of non-Hodgkin lymphoma and of several rheumatic diseases, it is associated with adverse events including the induction of autoimmune phenomena. We describe here the development of psoriatic skin lesions in a patient with rheumatoid arthritis after the second course of treatment with rituximab. This report supports the hypothesis that autoimmune phenomena may occur by biologic agents and there is a link between B-cell depletion and the induction of psoriatic skin lesions, which were confirmed histologically. However, further studies are needed in order to identify the underlying mechanism, as well as the risk factors associated with rituximab-induced psoriatic skin lesions.

journal_name

Clin Exp Rheumatol

authors

Markatseli TE,Kaltsonoudis ES,Voulgari PV,Zioga A,Drosos AA

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

996-8

issue

6

eissn

0392-856X

issn

1593-098X

pii

2855

journal_volume

27

pub_type

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