Abstract:
OBJECTIVE:To assess the effects of initial treatment with intravenous methylprednisolone (IVMP) on the clinical course and laboratory measurements in patients with juvenile dermatomyositis (JDM), and to report the long-term prognosis of these patients. METHODS:This was a retrospective study of 24 children with JDM, treated with IVMP as the initial therapy since 1981 and followed for a mean of 5.3 yrs. (range 10 months to 12.5 yrs.). Clinical and laboratory data, and complications of the disease and of therapy were ascertained by a chart review. RESULTS:The disease in 13/24 patients initially treated with IVMP followed a monocyclic course. The mean time for patients with a monocyclic course to normalize skin and muscle strength parameters was shorter than for patients with a chronic course (p < 0.005). Patients with a chronic course received more IVMP (mean 12.3 doses) (p < 0.005), and took longer to achieve normal strength (14.9 mos.) (p < 0.005), and remission of skin rash (33.7 mos.) (p < 0.005). Patients with a chronic course suffered more disease- and treatment-related complications than patients with a monocyclic course. CONCLUSION:Most patients whose disease followed a monocyclic course achieved normal muscle enzymes within one month and had improved muscle strength within 2.5 months of the initiation of therapy. If patients fail to achieve normal muscle strength over 4 months, muscle enzymes over 3 months and normalizing VWF over 10 months, there may be a higher probability that their disease will follow a chronic course.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Huang JLkeywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
621-4issue
5eissn
0392-856Xissn
1593-098Xjournal_volume
17pub_type
杂志文章abstract::A European Consensus Group study, involving 29 centres from 14 countries, was performed in order to reach agreement on the definition of disease activity in systemic lupus erythematosus (SLE) and to construct a new disease index. Data on 704 lupus patients were collected and analysed, using univariate and multivariate...
journal_title:Clinical and experimental rheumatology
pub_type: 共识发展会议,杂志文章,多中心研究,评审
doi:
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVES:To test the acceptability, feasibility, reliability and validity of the Italian translated version of the UCLA Scleroderma Clinical Trial Consortium GIT (UCLA-SCTC GIT) 2.0. Gastrointestinal tract (GIT) involvement is frequent in systemic sclerosis (SSc). The UCLA-SCTC GIT 2.0 is a validated instrument for m...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2015-07-01 00:00:00
abstract::There is increasing evidence supporting the involvement of Leu 1+B cells in the development of human autoimmune diseases. In this study, the frequency of Leu 1+B cells has been analysed by a multiparameter FACS machine in newborn cord blood, and in the peripheral blood of several autoimmune patients and their healthy ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVES:To assess the ability of efficacy measures that incorporate onset or sustainability to detect treatment effect or reflect patient satisfaction, using exploratory analyses of data from the ATTAIN (Abatacept Trial in Treatment of Anti-TNF INadequate Responders) trial. METHODS:218 abatacept- and 99 placebo-tre...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2010-03-01 00:00:00
abstract::Acquired hemophilia is associated with diverse conditions such as post-partum period, autoimmune diseases, cancers, and lymphoproliferative diseases. We report a case of acquired hemophilia occurring in Sjögren's syndrome which was treated with corticoid therapy. A review of the different treatments of acquired hemoph...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVE:To explore the main patterns of Behçet's disease (BD) expression, applying factor analysis. METHODS:Sixty-eight BD patients were studied. The following disease manifestations were used for the factor analysis: genital ulcerations, typical skin lesions (erythema nodosum, folliculitis or papulo-pustular rash),...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence and clinical correlations of antibodies against Saccharomyces cerevisiae (ASCA) among patients with BD. METHODS:Twenty-seven BD patients were studied. Data from medical files and from patients' interviews was collected, regarding the entire spectrum of disease manifestations, and a...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To answer and comment on a number of controversial issues in relation to osteoporosis and rheumatoid arthritis (RA), including: Is osteoporosis an extra-articular manifestation of rheumatoid arthritis? Does periarticular osteoporosis reflect disease activity in early arthritis? Is there a threshold for cortic...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1995-09-01 00:00:00
abstract::Osteoporosis diagnosis and treatment are commonly overlooked by primary care providers and patients, leading to significant morbidity, mortality and unnecessary health care costs. Fewer than 20% of patients receive screening or treatment for osteoporosis following fragility fractures. In addition, bone density screeni...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2007-11-01 00:00:00
abstract::An immunological imbalance is probably one of the major pathogenetic causes of rheumatoid arthritis in adults as well as in children. This aspect is the rationale for the use of immuno-modulating drugs. In our study we evaluated the effects of intravenously-administered thymopentin on systemic and local features in 10...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Several cases of patients with concomitant SLE and HIV infection have been reported in the literature; however, the effect of immunosuppressive therapy on HIV replication has not been described. We present the case of a 46 y/o woman with a ten-year history of HIV infection who was treated with IV cyclophosphamide for ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2000-07-01 00:00:00
abstract::We report herein the results of the cross-cultural adaptation and validation into the Korean language of the parent's version of two health related quality of life instruments. The Childhood Health Assessment Questionnaire (CHAQ) is a disease specific health instrument that measures functional ability in daily living ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:To test the hypothesis that classical phagocytic functions are constitutively stimulated in patients with Behçet's disease (BD). METHODS:Four study groups were analysed: active BD (aBD; n=30), inactive BD (iBD; n=31); septic patients (SP; n=25); healthy controls (HC; n=30). Microbicide activity against Stre...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the relationship between rheumatoid arthritis (RA) and the occurrence of diabetes mellitus (DM). METHODS:A meta-analysis was conducted to explore the risk of DM in RA patients. All relevant studies were identified by searching PUBMED, EMBASE and MEDLINE database prio...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,meta分析,评审
doi:
更新日期:2015-01-01 00:00:00
abstract::In a single-blind, randomized clinical trial, both the efficacy and safety of hyaluronic acid (HA) were compared with that of mucopolysaccharide polysulfuric acid ester (MPA) in patients with osteoarthritis of the knee joint. Both agents were administered intra-articularly over six weeks. Patients received either seve...
journal_title:Clinical and experimental rheumatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1993-07-01 00:00:00
abstract::****************************************************************************. ...
journal_title:Clinical and experimental rheumatology
pub_type: 信件
doi:
更新日期:2017-03-01 00:00:00
abstract::Alteration of the distribution pattern and composition of glycosaminoglycans (GAG) and proteoglycans may play an important role in the development of autoimmune diseases. Recent experiments indicate that anti-DNA antibodies cross-reacting with hyaluronic acid, heparan sulphate and chondroitin sulphate are present in p...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVES:This study evaluated the SDF-1/CXCL12 and soluble CXCR4 (sCXCR4) levels, and investigated their clinical relevance in adult-onset Still's disease (AOSD). METHODS:Forty-two AOSD patients and 30 healthy controls (HC) were enrolled for serum sampling. Expression levels of CXCL12 and CXCR4 in skin biopsy materi...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2019-11-01 00:00:00
abstract::The occurrence of interleukin-1 immunoreactive nerves in the synovial membrane of rat knee joints was investigated by immunohistochemistry. Synovial tissue sections from 11 rats consistently showed interleukin-1 positive nerve fibres. The majority of the fibres appeared in blood vessel walls. However, varicose interle...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::In this study we evaluated the efficacy of Infliximab in the treatment of adult Still's disease (ASD) refractory to conventional therapy. Three patients with chronic and active ASD unresponsive to corticosteroids and methotrexate were given intravenous Infliximab infusions at a dosage of 3 mg/kg at weeks 0, 2, 6 and t...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::A new pain rating scale, Analogue Chromatic Continuous Scale (ACCS), has been developed. The ACCS was tested in fifty consecutive patients suffering from pain of different origins, and compared with a simple descriptive scale (SDS) and a traditional 100 mm visual analogue scale (VAS). VAS and ACCS values showed a high...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::Low-dose methotrexate (MTX) remains the first-line treatment option among the disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. However, diverse side effects are the major reason for MTX withdrawal and change of treatment. The following article reviews the published data on general and organ...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:To compare and analyse the recommendations from clinical practice guidelines (CPGs) on gout worldwide, examine the consistency across CPGs, and provide suggestions to develop and update gout guidelines. METHODS:We conducted systematic searches in MEDLINE, CBM, GIN, NICE, NGC, WHO, SIGN, DynaMed, UpToDate, a...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:Primary Sjögren's syndrome (pSS) is one of the most prevalent systemic autoimmune diseases characterised by inflammation and tissue damage of exocrine glands, especially salivary or lacrimal gland. IL-17 related immune response is pathogenic with proinflammatory feature in pSS. However, whether IL-17E, an IL...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2020-06-12 00:00:00
abstract:OBJECTIVES:Primary cardiac manifestation is a common complication of systemic sclerosis (SSc) with poor prognosis. The aim of the current study was to detect potential myocardial inflammation present in asymptomatic SSc patients by 18F-FDG-PET/CT and to investigate its relationship with early signs of myocardial dysfun...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Autoimmune thyroiditis (ATD) has been linked to various forms of arthritis. The relationship with spinal degenerative disc disease (DDD) is not known. We studied the association between ATD and spinal DDD. METHODS:We performed a cross-sectional analysis of patients who had data on both anti-thyroid peroxida...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2016-03-01 00:00:00
abstract::A severe outbreak of coronavirus disease 2019 (COVID-19) emerged in China in December 2019, and spread so rapidly that more than 200,000 cases have so far been reported worldwide; on January 30, 2020, the WHO declared it the sixth public health emergency of international concern. The two previously reported coronaviru...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
doi:
更新日期:2020-03-01 00:00:00
abstract::Cardiac conducting tissue antibodies (CCTA) were detected, using indirect immunofluorescence, in 8 (25%) out of 32 sera from patients with progressive systemic sclerosis (PSS) and in 39 (35%) out of 110 with rheumatoid arthritis (RA). Conduction abnormalities, namely right bundle branch block, were present in 19 (59%)...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVES:To evaluate an Ankylosing Spondylitis-specific Arthritis Self-Efficacy Scale (ASES-AS) United Kingdom (UK) secondary care population. METHODS:The ASES-AS is based on the 8-item ASES with minor alterations in phraseology. Patients from ten secondary care rheumatology centres across England were asked to comp...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
abstract::Takayasu's arteritis (TA) is a chronic inflammatory arteriopathy affecting the large vessels and has been described predominantly in young adult women. In children it presents as an aggressive disease usually requiring chronic corticosteroid therapy. At present, low dose oral methotrexate (MTX) appears to be an effect...
journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
更新日期:1998-05-01 00:00:00