Abstract：
OBJECTIVE:Growth failure is a leading problem in uncontrolled juvenile idiopathic arthritis. It also affects 10% of patients who are not treated with corticosteroids. The influence of proinflammatory cytokines like interleukin-1 beta, interleukin-6 and tumour necrosis factor on the neuroendocrine axis as well as on the production of insulin-like growth factors (IGFs) has been postulated. The objective of the current study was to evaluate effects of highly active antirheumatic treatment with tumour necrosis factor antagonist on growth retardation. Seven out of 18 patients with refractory juvenile idiopathic arthritis treated with etanercept demonstrated growth retardation leading to short stature. METHODS:Antropometric measurements and disease activity parameters--including the number of swollen and tender joints, morning stiffness, ESR and CRP levels--were monitored monthly during the first year of treatment and every 3 months thereafter. Serum levels of IGF-1 and IFG-BP were measured as well. RESULTS:Upon treatment with etanercept, growth velocity increased from 3.7 +/- 1.2 cm before the beginning of the therapy to 7.6 +/- 1.2 cm in the first year of treatment (p < 0.001). The average length-standard-deviation-score (SDS) increased from -2.4 +/- 1.0 to -1.9 +/- 0.9 after one year and to -1.1 +/- 0.9 after two years (p = 0.05) indicating catch-up growth. Prior to the therapy, serum levels of insulin-like growth factor-1 and of insulin-like growth factor binding protein-3 were within the normal range but increased significantly upon treatment (p < 0.001). An inverse correlation of the IGF-1 serum level to CRP was found. CONCLUSIONS:An intensified anti-inflammatory treatment using etanercept has a beneficial effect on growth in children with a so far uncontrolled inflammatory disease. This effect might be related to the cessation of the inhibitory effect of proinflammatory cytokines on the synthesis of IGF-1 and IGF-BP-3 in the liver. Growth failure should be included in the evaluation of antirheumatic treatment.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Schmeling H,Seliger E,Horneff Gkeywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
779-84issue
6eissn
0392-856Xissn
1593-098Xjournal_volume
21pub_type
杂志文章abstract：OBJECTIVES:Beyond their role in haemostasis, platelets can actively contribute to immunity. The activation of the platelet collagen receptor glycoprotein VI (GPVI) promotes the release of small extracellular vesicles called microparticles. These microparticles are found in the joint bathing fluid of patients with rheum...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究
doi：
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVES:Secreted aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1) has been reported to have pro-inflammatory properties. The aim of this study was to evaluate the clinical significance of serum AIMP1 in patients with systemic lupus erythematosus (SLE). METHODS:Serum levels of AIMP1 were measu...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2018-07-01 00:00:00
abstract：:A Yersinia pseudotuberculosis serotype III outbreak in 1982 was characterized by a high frequency of post-infectious complications. Ten years later 16 out of the 19 patients originally included in the outbreak were reached for a follow up evaluation. Altogether nine patients suffered from chronic joint symptoms. Four ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To compare the efficacy and safety of intraarticular glucocorticoid injection to its systemic use for treatment of knee synovitis in rheumatoid patients. METHODS:A randomized double-blind controlled study was conducted including 60 patients with RA. Patients were randomized to receive either a single intraar...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2009-03-01 00:00:00
abstract：:An immunological imbalance is probably one of the major pathogenetic causes of rheumatoid arthritis in adults as well as in children. This aspect is the rationale for the use of immuno-modulating drugs. In our study we evaluated the effects of intravenously-administered thymopentin on systemic and local features in 10...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：OBJECTIVES:To determine the prevalence of juvenile fibromyalgia syndrome (JFMS) in children with familial Mediterranean fever (FMF) and to evaluate quality of life (QoL) and depression. METHODS:Ninety-one FMF patients (M/F: 44/47) who fulfilled the Livneh criteria and 60 healthy children (M/F: 27/33) were enrolled in ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：:In all forms of rheumatic disease in childhood, early and accurate diagnosis is essential. The aims of therapy in juvenile arthritis are pain relief and the preservation of joint function while maintaining normal growth and psychological development. As management is complex it will require a coordinated, multi-discip...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1994-09-01 00:00:00
abstract：:Lymphocyte subpopulations and functions were examined in the salivary (parotid) gland lymphocytes (SGL) obtained as a cell suspension from a patient with Sjögren's syndrome associated with rheumatoid arthritis, in comparison with peripheral blood lymphocytes (PBL). Serial studies on the lymphocyte subsets in PBL using...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVES:Rheumatoid arthritis (RA) is a systematic autoimmune disease that cardinally affects the joints and other organs. Many people all over the world are suffering from the disease and no effective treatment has been established. Fibroblast-like synoviocytes (FLSs) play a critical role in the occurrence and devel...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-07-01 00:00:00
abstract：:Ultrasound (US) has acquired an increasing role in the assessment of joint and periarticular abnormalities in osteoarthritis (OA). It is able to image a large set of abnormalities in this disease which include both inflammatory and structural changes at different peripheral joint sites and it is helpful in guiding loc...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2017-05-01 00:00:00
abstract：:Patients with ankylosing spondylitis (AS) may develop cardiovascular manifestations ranging from asymptomatic forms to life threatening conditions. The most important cardiovascular manifestation of AS is aortitis, which frequently involves the aortic root and the ascending aorta leading to valvular insufficiency. The...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2008-05-01 00:00:00
abstract：:We report a retrospective study of 17 patients with systemic lupus erythematosus who were treated with oral methotrexate given as a mean weekly dose of 8.47 +/- 1.72 mg. Methotrexate treatment resulted in symptomatic improvement in 57% of patients and allowed the reduction of the mean daily dose of prednisone from 16....
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：OBJECTIVE:We have developed a self-taught course by which rheumatologists in training can learn how to conduct capillaroscopy examinations using a computerized videomicroscopy system. We assessed the effectiveness of this course by following the learning curve of one specialist trainee with no experience in capillarosc...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVES:Autoimmune thyroiditis (ATD) has been linked to various forms of arthritis. The relationship with spinal degenerative disc disease (DDD) is not known. We studied the association between ATD and spinal DDD. METHODS:We performed a cross-sectional analysis of patients who had data on both anti-thyroid peroxida...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
abstract：:Neuropathic arthritis is a destructive arthropathy frequently associated with loss of proprioception. A third of patients, however, may have no demonstrable neurological deficit. Patients with diabetes, syphilis, syringomyelia and other neuropathies are particularly prone to developing this joint disease. The diagnosi...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1994-05-01 00:00:00
abstract：:Skin biopsies from 4 systemic sclerosis (SSc) patients, 6 SSc patients treated with D-penicillamine (from 8 to 60 months) and 4 normal subjects were analyzed by light and electron microscopy. By light microscopy, collagen bundles of SSc dermis were thicker and more compact than in age-matched controls; D-penicillamine...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:As rheumatoid arthritis (RA) patients have been shown to have impaired plasma fibrinolysis and fish oil has been suggested to be useful for RA, this study investigated the effects of fish oil on fibrinolytic parameters in patients with RA. Forty-five RA patients were randomised to receive either fish oil (1.7 gm eicos...
journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVES:To compare salivary cytokine profiles in patients with primary Sjögren's syndrome (pSS), non-SS sicca controls, and non-sicca controls, and to investigate whether cytokine levels are correlated with clinical parameters of pSS patients. METHODS:Un-stimulated whole saliva samples were obtained from pSS patien...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to investigate whether the urokinase gene 3'-UTR C/T polymorphism is a marker of susceptibility to or severity of rheumatoid arthritis (RA) in Chinese patients. METHODS:A total of 145 RA patients and 134 healthy control subjects were enrolled in this study. We identified the C/...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:Since 1990 the Utrecht Rheumatoid Arthritis Cohort study group has performed several clinical trials on different treatment strategies in early rheumatoid arthritis (RA) patients. From 1990 till 1994, patients were randomly assigned to the pyramid strategy group or the early DMARD group. Patients in the early DMARD gr...
journal_title：Clinical and experimental rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2003-09-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) has been described by many authors as a multisystem disorder involving variable and protean clinical manifestations and with an unpredictable course. We report the case of a 68-year-old woman suffering from SLE in whom tremor appeared ten years before a clinical picture suggestive of...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:The idiopathic inflammatory myopathies (IIMs) are a rare group of immune, systemic diseases characterised by muscle inflammation and frequently by extramuscular involvement. IIMs are heterogeneous with generally a chronic or subacute onset, which vary from less severe to more serious manifestations, not always easy to...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:To evaluate basal serum prolactin (PRL) levels in systemic sclerosis (SSc) patients with different degrees of skin involvement, and investigate its relationship with some of the clinical and serological parameters of the disease. METHODS:Basal serum PRL was measured in 44 SSc patients (38 F, 6 M) using a ra...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:Calcinosis is a devastating complication of juvenile dermatomyositis and a challenging therapeutic problem. We report the use of an external Ilizarov fixator for the treatment of Achilles tendon calcinosis causing severe disability in a young girl with juvenile dermatomyositis. ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:The definition of remission in patients with systemic vasculitis must be distinguished from the term "cure," which implies that patients are well and not requiring ongoing therapy. Remission should be defined using a standardised approach to measuring clinical disease activity, and the definition should be qualified b...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2006-11-01 00:00:00
abstract：:A series of different ultrasonographic abnormalities detected by salivary gland echography (SGE) were investigated for their discriminant power for Sjögren's syndrome (SS) in 53 patients with either primary SS (n = 27) or secondary SS (n = 26), as well as in 90 controls. Among the controls, 26 suffered from dry mouth ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Endogenous or exogenous glucocorticoids play a key role in the control of the immune and inflammatory network. Regulation of the effects of the glucocorticoids depends on changes in therapeutic levels, but also, as recently discovered, on modifications of the binding characteristics of the glucocorticoid receptors of ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-05-01 00:00:00
abstract：:Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the failure of multiple clinical trials directed at B cell depletion or inhibition. To date, most prognostic markers for severe disease out...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:We aimed to assess changes in myositis core set measures and ancillary clinical and laboratory data from the National Institutes of Health's subset of patients enrolled in the Rituximab in Myositis trial. METHODS:Eighteen patients (5 dermatomyositis, 8 polymyositis, 5 juvenile dermatomyositis) completed mor...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVE:To determine how frequently herbal remedies are employed as alternative therapies in rheumatic diseases, and the historical justification for their use. METHODS:We conducted a survey in 250 outpatients in the rheumatology clinic of a teaching hospital in México. We registered general demographic information ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
