Methotrexate for systemic lupus erythematosus: a retrospective analysis of 17 unselected cases.

Abstract:

:We report a retrospective study of 17 patients with systemic lupus erythematosus who were treated with oral methotrexate given as a mean weekly dose of 8.47 +/- 1.72 mg. Methotrexate treatment resulted in symptomatic improvement in 57% of patients and allowed the reduction of the mean daily dose of prednisone from 16.66 mg initially to 8.99 mg at one year follow-up. Twelve of 17 patients (70.6%) experienced at least one episode of toxicity. Factors which might be associated with toxicity are analyzed. Because of its potential as a corticosteroid-sparing agent, controlled studies of methotrexate for the treatment of systemic lupus erythematosus are indicated.

journal_name

Clin Exp Rheumatol

authors

Wilke WS,Krall PL,Scheetz RJ,Babiak T,Danao T,Mazanec DJ,Segal AM,Clough JD

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

581-7

issue

6

eissn

0392-856X

issn

1593-098X

journal_volume

9

pub_type

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