Abstract:
OBJECTIVES:Rheumatoid arthritis (RA) is characterised by an excess of cardiovascular diseases (CVD) risk, attributable to a synergy between under-diagnosed traditional risk factors (i.e. insulin resistance) and inflammatory disease activity. The aim of the present study was to evaluate the correlation between inflammatory measures and insulin sensitivity in RA patients. METHODS:Forty non-diabetic RA patients (19 males) were recruited. All patients underwent anthropometric measurements, laboratory evaluation and oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI) was calculated with the equation proposed by Matsuda et al., from dynamic values of glucose and insulin obtained during OGTT. RESULTS:In the univariate analysis, lnISI correlated inversely with age, BMI, waist circumference, sBP, ESR, lnCRP and complement C3, but not with disease duration, dBP or complement C4. In non-obese patients (BMI <30 kg/m2, n=28), only age, BMI, lnCRP and C3 maintained their correlation with lnISI. In a stepwise multiple regression using lnISI as the dependent variable and BMI, age, lnCRP and complement C3 as predictors, only BMI and C3 entered the equation and accounted for 38.2% of the variance in lnISI. In non-obese patients, only C3 entered the regression equation, accounting for 32.2% of the variance in lnISI. Using a ROC curve, we identified the best cut-off for complement C3 of 1.22 g/L that yielded a sensitivity of 67% and a specificity of 79% for classification of insulin resistant patients. CONCLUSIONS:In RA patients, complement C3 correlates strongly with insulin sensitivity, in both obese and non-obese individuals.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Ursini F,D'Angelo S,Russo E,Arturi F,D'Antona L,Bruno C,Naty S,De Sarro G,Olivieri I,Grembiale RDsubject
Has Abstractpub_date
2017-01-01 00:00:00pages
18-23issue
1eissn
0392-856Xissn
1593-098Xpii
10128journal_volume
35pub_type
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,多中心研究
doi:
更新日期:2008-05-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,随机对照试验
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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journal_title:Clinical and experimental rheumatology
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pub_type: 杂志文章
doi:
更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章,meta分析
doi:
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pub_type: 杂志文章,多中心研究
doi:
更新日期:2012-11-01 00:00:00
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doi:
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章
doi:
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doi:
更新日期:2014-11-01 00:00:00
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journal_title:Clinical and experimental rheumatology
pub_type: 杂志文章,评审
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更新日期:1989-09-01 00:00:00
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journal_title:Clinical and experimental rheumatology
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doi:
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doi:
更新日期:2018-11-01 00:00:00
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doi:
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doi:
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更新日期:2008-03-01 00:00:00
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更新日期:1997-11-01 00:00:00
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更新日期:2011-11-01 00:00:00
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