当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL RHEUMATOLOGY期刊下所有文献 > A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome.

A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome.

Abstract：

OBJECTIVES:ACA-positive/primary Sjögren's syndrome (pSS) represents a distinct overlapping entity with intermediate features in between limited systemic sclerosis (lSSc) and pSS. Few data are available on their general risk for lymphoproliferative complications, specifically regarding adverse predictors at the level of minor salivary gland (MSG) histology. The objectives of this work are: a) to characterise, through a detailed immunohistochemistry study, the organisation of the lymphomonocitic infiltrates in ACA-positive/pSS patient vs. ACA-negative/pSS patients focusing on the presence of GC-like structures in minor salivary gland biopsies; b) to compare the frequency of traditional clinical and serological risk factors for lymphoma between the two subgroups. METHODS:We analysed 28 MSG samples from ACA-positive/pSS patients and 43 consecutive MSGs from ACA-negative/pSS, using sequential IHC staining for CD3, CD20 and CD21 in order to define the T/B cell segregation within the periductal infiltrates and presence of ectopic GC-like on the detection of GC-like structures. Clinical and serological data of all the patients were retrieved and analysed. RESULTS:Ectopic lymphoid structures (ELS) with GC-like structures were observed in 7 out of 28 ACA-positive/pSS patients (25%) and in 13 out of 43 ACA-negative/pSS patients (30.2%). Similarly, no statistical significant difference was found between the two groups as far as the classical pSS risk factors for lymphoproliferative complications was concerned (i.e. salivary gland enlargement, purpura, low C4, leukocytopenia, clonal gammopathy). Finally, the 3 cases of non-Hodgkin's lymphoma observed were equally distributed between the two subsets. CONCLUSIONS:Overall, this study indicates that ACA-positive/and ACA-negative pSS patients apparently present a similar risk for lymphoproliferative complications as suggested indirectly by the analogies between the two groups observed at the histopathology level.

journal_name

Clin Exp Rheumatol

journal_title

Clinical and experimental rheumatology

authors

Notarstefano C,Croia C,Pontarini E,Lucchesi D,Sutcliffe N,Tappuni A,Donati V,Pitzalis C,Baldini C,Bombardieri M

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

145-149

issue

eissn

0392-856X

issn

1593-098X

pii

13087

journal_volume

36 Suppl 112

pub_type

杂志文章,多中心研究

在线工具

A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome.