Abstract：
OBJECTIVE:To assess the response to and safety of long term, high dose (> or = 1 mg/kg/week or > or = 15 mg/m2/week) methotrexate (MTX) administration, in a cohort of 21 children with longstanding, severe juvenile rheumatoid arthritis (JRA). METHODS:Children received MTX at an average weekly dose of 27 mg for a mean of 15.2 months. Outcome was assessed using a disease activity score based on changes in concomitant therapy, laboratory parameters, physician's global assessment, and radiologic evaluation. RESULTS:Seven patients (33%) improved, including one child who achieved complete remission, while 14/21 children (67%) did not benefit from high dose MTX. Subsequently, 6/14 (43%) of the non-responders discontinued high dose MTX and began cyclosporine. Radiologic progression, regardless of clinical outcome, was documented in 10/15 (67%) of the patients. The drug was well tolerated despite mild gastrointestinal symptoms and transient liver enzyme elevation. CONCLUSION:The results of this open retrospective pilot trial suggest that high dose MTX is well tolerated, but that its role in the treatment of children with refractory JRA may be limited. Radiologic progression, despite improvement in the clinical status or in the laboratory parameters, supports the hypothesis that MTX acts as a potent antiinflammatory agent.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Reiff A,Shaham B,Wood BP,Bernstein BH,Stanley P,Szer ISsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
113-8issue
1eissn
0392-856Xissn
1593-098Xjournal_volume
13pub_type
临床试验,杂志文章abstract：:The Technetium Articular Index (TcAI) is regarded as a parameter of local inflammation in rheumatoid arthritis (RA). We studied TcAI behaviour during 1-year chrysotherapy in a group of fifteen RA patients. In non-responders TcAI showed a gradual decrease up to the 6th month and a return to baseline values within the s...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:To determine the effects of rhein on the expression of matrix metalloproteinases (MMP-1, -3, 13) and ADAMTs 4, 5 (a disintegrin and metalloproteinase with thrombospondin type-I repeat)/aggrecanases-1, -2 in interleukin-1-stimulated bovine articular chondrocytes, and to investigate the signalling pathways invo...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVES:To assess in daily practice in patients with rheumatoid arthritis (RA) the effect of treatment with first tumour necrosis factor-α inhibitor (TNFi) in quality of life (Qol), disease activity and depict possible baseline predictors for gains in Qol. METHODS:Patients followed prospectively by the Hellenic Reg...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2016-11-01 00:00:00
abstract：:Monoclonal antibody against c-myc protein was used in the avidin-biotin-peroxidase complex procedure to examine frozen sections of psoriatic and normal skin and psoriatic synovium for the presence of c-myc protein. A significantly greater percentage (88%) of epithelial cells from psoriatic skin lesions stained for c-m...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Peripheral joint involvement is a common, potentially debilitating feature of psoriatic arthritis (PsA). Joint involvement is commonly symmetrical and polyarticular similar to rheumatoid arthritis (RA) but it can also be oligoarticular, asymmetrical or occasionally monoarticular. Involvement of the distal interphalang...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitute a subgroup of life-threatening diseases which affects the kidney in more than half of the patients at diagnosis. Currently, little has been published focusing on AAV patients with dialysis. We analysed AAV patients with chronic...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:Our first objective was to make an inventory of available instruments for the assessment of disabilities in gait and related activities in patients with rheumatic disorders. Our second aim was to investigate which of these instruments have acceptable methodological quality with regard to reliability and vali...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:To determine the value of Positron Emission Tomography (PET) in the diagnosis of Takayasu arteritis (TA) and giant cell arteritis (GCA) and its value in the assessment of disease activity and response to therapy. METHODS:In 5 consecutive patients diagnosed with TA or GCA, PET using the tracer F18-deoxygluco...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:This paper aims to explore the functional significance of the P2X7 receptor in preclinical models of rheumatoid arthritis. METHODS:Preclinical studies in vivo were performed using the rat streptococcal cell wall (SCW) arthritis model. Ex vivo cultures of lipopolysaccharide (LPS)/benzoylbenzoyl adenosine tri...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:The threshold for pharmacological intervention for osteoporosis remains controversial. Tools predicting the future risk of new fractures are increasingly used to establish a convenient individual risk/benefit ratio for a long term treatment. FRAX® is likely to become the most widely used tool for assessing fracture ri...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVES:Rheumatoid arthritis (RA) is characterised by an excess of cardiovascular diseases (CVD) risk, attributable to a synergy between under-diagnosed traditional risk factors (i.e. insulin resistance) and inflammatory disease activity. The aim of the present study was to evaluate the correlation between inflammat...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:Non-genetic risk factors for Sjögren's syndrome (SS) are poorly understood. Adherence to a Mediterranean diet has been associated with reduction in other autoimmune diseases. We examined the association of Mediterranean diet with SS. METHODS:New patients attending a single centre warranting investigation fo...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-07-01 00:00:00
abstract：:The frequency of attachment of certain members of the Enterobacteriaceae implicated in arthritis to buccal epithelial cells from patients with post-Yersinia reactive arthritis, Yersinia enteritis and from healthy controls was examined using a fluorescent labelling technique. Klebsiella K43 bound significantly more fre...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:The M.D.R. index is a new instrument which has been designed to give a measurement of physical function in inflammatory joint disease. It is very easy to apply and is not time-consuming. In preliminary assessment, the index has proven to be highly reliable. It has also been sufficiently sensitive to detect short-term ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：OBJECTIVE:The aim of this consensus process was to construct a preliminary version of the ICF Core Set for acute inflammatory arthritis. METHODS:The development of the ICF Core Set involved a formal decision-making and consensus process, integrating evidence gathered from preliminary studies including focus groups of ...
journal_title：Clinical and experimental rheumatology
pub_type： 共识发展会议,杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:Cryopyrin-associated periodic syndrome (CAPS), a rare hereditary auto-inflammatory disease, is associated with mutations in the NLRP3 gene resulting in elevated interleukin-1β (IL-1 β) release. CAPS generally occurs in early childhood with most patients presenting with periodic fever, skin rash, osteoarthrop...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVES:Although oligoarticular juvenile idiopathic arthritis (oJIA) is considered to carry the best prognosis among the JIA subtypes, many children evolve to a chronic course. A few studies have identified clinical risk factors for disease extension, and recent studies have evaluated synovial fluid markers. However...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:The link between specific antibodies and atherogenesis in primary antiphospholipid syndrome (PAPS) is less strong than for thrombosis, although clearly the two processes are related and thrombosis is the main complication of atherosclerosis, a process known as atherothrombosis. The aim of this study was to in...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
abstract：:This study examines the interrelationship between arachidonic acid (AA) metabolism and chemotactic potential of human peripheral blood neutrophils from both normal donors and patients with rheumatoid arthritis (RA). We demonstrate that there is a significant inverse relationship between the neutrophil's metabolic capa...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：OBJECTIVES:Systemic lupus erythematosus (SLE) is a chronic autoimmune multi-organ disease with an unpredictable course. SLE causes functional disability, changes in body appearance, and psychological distress. When faced with SLE, patients have to implement coping strategies. Therefore, the aim of this study was to des...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVES:To analyse the worldwide occurrence of sicca/Sjögren's (SS) syndrome associated with the use of immune checkpoint inhibitors (ICI) in patients with cancer. METHODS:The ImmunoCancer International Registry (ICIR) is a Big Data-Sharing multidisciplinary network composed by 40 specialists in Rheumatology, Inter...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVES:Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD) resulting from impairments in vascular function and morphology. CVD risk prediction scores can identify patients at high risk of CVD, but little is known about whether they relate with assessments of vascular fu...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the relationship between serum infliximab (IFX) levels and changes of RF and ACPA levels in patients with rheumatoid arthritis (RA). METHODS:Enzyme-linked immunosorbent assays (ELISA) [Promonitor® IFX R1 (version 2) (Progenika Biopharma, Spain)] were used to measure ...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
abstract：:Surgical treatment of rheumatoid arthritis dates back some fifty years to when rheumatology developed into a separate branch of medicine. An interdisciplinary approach to rheumatoid arthritis was then introduced at a few specialized centres. By refining the surgical techniques, increasing the number of surgical option...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：1989-09-01 00:00:00
abstract：:Etanercept is a recombinant soluble tumour necrosis factor alpha receptor administered subcutaneously at the dose of 50 mg weekly (or 25 mg/twice weekly) for the treatment of the main chronic arthritides: rheumatoid arthritis and spondyloarthropathies. It shows high qualities in terms of efficacy and manageability. Fa...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVES:Patients with clinically evident autoimmune disease are at increased risk for premature cardiovascular disease (CVD). Markers of serological autoimmunity such as anti-nuclear antibodies (ANA) are found in approximately 25% of the general population. Yet, the vast majority will not develop clinical autoimmune...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Complement-mediated injury is regulated by many factors; among these CD59 has been identified as a widely distributed glycoprotein that inhibits membrane C5b-9 (terminal complement component) formation. The aim of the study was to assess erythrocyte CD59 expression in patients with psoriatic arthritis in orde...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:In order to study local immunoregulatory mechanisms in patients with seronegative spondylarthropathy and histological evidence of asymptomatic intestinal inflammation, we determined mononuclear cells in distal ileal mucosa with an indirect immunoperoxidase technique using a panel of monoclonal antibodies. The number o...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：OBJECTIVES:We aimed to assess changes in myositis core set measures and ancillary clinical and laboratory data from the National Institutes of Health's subset of patients enrolled in the Rituximab in Myositis trial. METHODS:Eighteen patients (5 dermatomyositis, 8 polymyositis, 5 juvenile dermatomyositis) completed mor...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：
更新日期：2014-09-01 00:00:00
abstract：:The systemic vasculitides are a group of rare, chronic, relapsing, but often progressive inflammatory conditions. They are associated with a significant burden of morbidity both due to scarring from the disease itself and as a consequence of treatment with glucocorticoids and other potent immunosuppressive agents. Car...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
