Abstract：
OBJECTIVES:The aim of this study was to investigate the relationship between serum infliximab (IFX) levels and changes of RF and ACPA levels in patients with rheumatoid arthritis (RA). METHODS:Enzyme-linked immunosorbent assays (ELISA) [Promonitor® IFX R1 (version 2) (Progenika Biopharma, Spain)] were used to measure drug levels and antidrug-antibodies (ADAb) in IFX RA-treated patients (n=19). Disease activity was assessed using DAS28. IgM rheumatoid factor (RF) and IgM, IgA and IgG anti-cyclic citrullinated peptide (ACPA) were determined through ELISA. RESULTS:A significant decrease in RF (p=0.01), ACPA IgG (p=0.007), IgM (p=0.01) and IgA (p=0.03) was observed in patients presenting adequate levels of serum IFX. No significant changes to RF or ACPA were observed in patients with undetectable IFX. CONCLUSIONS:Data from this study support the hypothesis that the anti-TNF antagonist IFX downregulates autoantibody levels in RA patients when IFX levels are detectable. Larger-scale studies need to be performed to establish RF and ACPA presence as therapeutic response predictive factors.
journal_name
Clin Exp Rheumatoljournal_title
Clinical and experimental rheumatologyauthors
Martínez-Estupiñán L,Hernández-Flórez D,Janta I,Ovalles-Bonilla JG,Nieto JC,González-Fernández CM,Del Río T,Monteagudo I,López-Longo FJ,Naredo E,Valor Lsubject
Has Abstractpub_date
2018-01-01 00:00:00pages
88-93issue
1eissn
0392-856Xissn
1593-098Xpii
11405journal_volume
36pub_type
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journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
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abstract：:Olfaction plays an important role in the perception of our environment. Smell impairment is known to be a manifestation of several autoimmune diseases. Similarities between the olfactory and immune systems and previously published human studies and animal models of autoimmune diseases account for the accumulating evid...
journal_title：Clinical and experimental rheumatology
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：OBJECTIVES:To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive 'lone' hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. METHODS:Sera were obtained from a total of 99 patients wit...
journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2015-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2010-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章,多中心研究
doi：
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
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doi：
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2013-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2015-11-01 00:00:00
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doi：
更新日期：2020-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
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doi：
更新日期：2003-03-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2006-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
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journal_title：Clinical and experimental rheumatology
pub_type： 杂志文章
doi：
更新日期：2020-07-01 00:00:00
