Abstract:
:The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was estimated using HPLC analysis of beads dissolved in methanol. These proliposomal beads formed liposomes on disintegration in phosphate buffered saline (pH 7.4), which was confirmed by transmission electron microscopy. The dissolution study of enteric-coated beads exhibited enhanced dissolution compared with pure drug and a marketed product. Liposomes can be successfully prepared for oral administration in the form of enteric-coated beads that may offer a stable system to produce liposomes for oral administration.
journal_name
Drug Delivjournal_title
Drug deliveryauthors
Kumar R,Gupta RB,Betageri GVdoi
10.1080/107175401300002720keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
25-7issue
1eissn
1071-7544issn
1521-0464journal_volume
8pub_type
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