Antibacterial effects of trisubstituted quinazoline derivatives.

Abstract:

:Five trisubstituted quinazolones and eight trisubstituted quinazoline-4-thiones have been tested for antibacterial effects by a microdilution method. Four derivatives exerted a significant effect on E. coli, P. aeruginosa, S. aureus and B. subtilis (IC50 < 100 mg/L). In the bacterium P. aeruginosa six quinazolines showed a higher antibacterial effect than ampicillin. The most sensitive to the effects of the quinazolines was S. aureus; a concentration of 100 mg/L of six derivatives induced a bacteriostatic effect on S. aureus. The quinazoline-4-thiones were generally more active than the quinazolones. All the tested concentrations of the four most effective quinazolines influenced the specific growth rate.

journal_title

Folia microbiologica

authors

Jantová S,Greif G,Spirková K,Stankovský S,Oravcová M

doi

10.1007/BF02817411

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

133-7

issue

2

eissn

0015-5632

issn

1874-9356

journal_volume

45

pub_type

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