Abstract:
:Cryptococcus neoformans is encapsulated yeast that causes cryptococcosis. The cryptococcal meningitis may cause neuropsychiatric symptoms. Here, we evaluated the in vitro activity of amphotericin B (AMB), chlorpromazine (CLOR), and sertraline (SERT) alone or in combination against clinical isolates of C. neoformans considering the capsular induction in vitro. Susceptibility tests were carried out using the broth microdilution method in accordance with the CLSI document M27-A3. The combination [CLOR + AMB] exhibited synergism for 50 and 67 % of strains before capsular induction (group I) and after capsular induction (group II), respectively. The combination [SERT + AMB] showed 60 % of synergism against the both groups. Antagonism was not observed. Our results show the therapeutic potential of chlorpromazine and sertraline in combination with amphotericin B against neurocryptococcosis.
journal_name
Folia Microbiol (Praha)journal_title
Folia microbiologicaauthors
Rossato L,Loreto ÉS,Zanette RA,Chassot F,Santurio JM,Alves SHdoi
10.1007/s12223-016-0449-8subject
Has Abstractpub_date
2016-09-01 00:00:00pages
399-403issue
5eissn
0015-5632issn
1874-9356pii
10.1007/s12223-016-0449-8journal_volume
61pub_type
杂志文章abstract::Biochemical properties of a termostable alkaline phosphatase obtained from the mycelium extract of A. caespitosus were described. The enzyme was purified 42-fold with 32% recovery by DEAE-cellulose and concanavalin A-Sepharose chromatography. The molar mass estimated by Sephacryl S-200 or by 7% SDS-PAGE was 138 kDa an...
journal_title:Folia microbiologica
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journal_title:Folia microbiologica
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journal_title:Folia microbiologica
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journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02876990
更新日期:1977-01-01 00:00:00
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journal_title:Folia microbiologica
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doi:10.1007/BF02818794
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journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02816248
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journal_title:Folia microbiologica
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