Abstract:
:It is widely accepted that the large trinucleotide repeat expansions observed in many neurological diseases occur during replication. However, genetic recombination has emerged as a major source of instability for tandem repeats, including minisatellites, and recent studies raise the possibility that it may also be responsible for trinucleotide repeat expansions. We will review data connecting tandem repeat rearrangements and recombination in humans and in eukaryotic model organisms, and discuss the possible role of recombination in trinucleotide repeat expansions in human neurological disorders.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Richard GF,Pâques Fdoi
10.1093/embo-reports/kvd031keywords:
subject
Has Abstractpub_date
2000-08-01 00:00:00pages
122-6issue
2eissn
1469-221Xissn
1469-3178pii
embor606journal_volume
1pub_type
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