Abstract:
:The expression of metabotropic glutamate receptor 8 (mGluR8) was studied in the rat hippocampus after pilocarpine-induced status epilepticus (APISE) by light immunohistochemistry and immunoelectron microscopy. At 1 day APISE, mGluR8 immunoreactivity was up-regulated in the entire molecular layer of the dentate gyrus. At 7 days APISE, mGluR8 immunoreactive cells began to appear in the stratum lacunosum moleculare of CA1, and by day 31, they were seen in all layers of CA1. By electron microscopy and double labelling study, the mGluR8 immunoreactive cells were identified as astrocytes. The present novel finding of induced expression of mGluR8 in astrocytes APISE suggests that it may be linked to gliosis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tang FR,Lee WL,Yang J,Sim MK,Ling EAdoi
10.1016/s0304-3940(01)01579-8keywords:
subject
Has Abstractpub_date
2001-03-16 00:00:00pages
137-40issue
3eissn
0304-3940issn
1872-7972pii
S0304394001015798journal_volume
300pub_type
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