Abstract:
:The Tat system is a recently discovered protein export pathway that serves to translocate folded proteins, often containing redox cofactors, across the bacterial cytoplasmic membrane. Here we report that tat strains are associated with a mutant cell septation phenotype, where chains of up to 10 cells are evident. Mutant strains are also hypersensitive to hydrophobic drugs and to lysis by lysozyme in the absence of EDTA, and they leak periplasmic enzymes, characteristics that are consistent with an outer membrane defect. Both phenotypes are similar to those displayed by strains carrying point mutations in the lpxC (envA) gene. The phenotype was not replicated by mutations affecting synthesis and/or activity of all known or predicted Tat substrates.
journal_name
J Bacterioljournal_title
Journal of bacteriologyauthors
Stanley NR,Findlay K,Berks BC,Palmer Tdoi
10.1128/JB.183.1.139-144.2001keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
139-44issue
1eissn
0021-9193issn
1098-5530journal_volume
183pub_type
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