Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate.

Abstract:

:Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma(B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma(B) in S. aureus biofilm regulation under environmental stress conditions.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Rachid S,Ohlsen K,Wallner U,Hacker J,Hecker M,Ziebuhr W

doi

10.1128/jb.182.23.6824-6826.2000

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

6824-6

issue

23

eissn

0021-9193

issn

1098-5530

journal_volume

182

pub_type

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