Abstract：
:Bone mass and microarchitecture are the main determinants of bone strength. Three-dimensional micro-computed tomography has the potential to examine complete bones of small laboratory animals with very high resolution in a non-invasive way. In the presented work, the proximal part of the tibiae of hindlimb unloaded and control rats were measured with 3D MicroCT, and the secondary spongiosa of the scanned region was evaluated using direct evaluation techniques that do not require model assumptions. For determination of the complete bone status, the cortex of the tibiae was evaluated and characterised by its thickness. It is shown that with the proposed anatomically conforming volume of interest (VOI), up to an eight-fold volume increase can be evaluated compared to cubic or spherical VOIs. A pronounced trabecular bone loss of -50% is seen after 23 days of tail suspension. With the new evaluation techniques, it is shown that most of this bone loss is caused by the thinning of trabeculae, and to a lesser extent by a decrease in their number. What changes most radically is the structure type: the remaining bone is more rod-like than the control group's bone. Cortical bone decreases less than trabecular bone, with only -18% after 23 days.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Laib A,Barou O,Vico L,Lafage-Proust MH,Alexandre C,Rügsegger Pdoi
10.1007/BF02347054keywords:
subject
Has Abstractpub_date
2000-05-01 00:00:00pages
326-32issue
3eissn
0140-0118issn
1741-0444journal_volume
38pub_type
杂志文章abstract：:Reactive hyperaemia is the term given to the temporary increase in blood flow that follows release of an occlusion of the arterial supply. Measurement of reactive hyperaemia in the leg below the knee is useful in assessment of the vascular system, as resting flows remain unaffected even in the presence of quite severe...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02515312
更新日期：1994-09-01 00:00:00
abstract：:We investigate a new framework of surgical instrument detection based on power-varying ultrasound images with simple and efficient pixel-wise intensity processing. Without using complicated feature extraction methods, we identified the instrument with an estimated optimal power level and by comparing pixel values of v...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1695-x
更新日期：2018-03-01 00:00:00
abstract：:Widespread misconceptions still exist regarding the formation of extracellular potentials over the innervation zone: the assumption (1) that the first phase of these potentials mainly reflects the process of initiation of the intracellular action potential (IAP) at the neuromuscular junction and that (2) these potenti...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1487-8
更新日期：2016-12-01 00:00:00
abstract：: ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,撤回出版物
doi：10.1007/s11517-018-1933-x
更新日期：2019-03-01 00:00:00
abstract：:A generic framework for the automated classification of human movements using an accelerometry monitoring system is introduced. The framework was structured around a binary decision tree in which movements were divided into classes and subclasses at different hierarchical levels. General distinctions between movements...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02347551
更新日期：2004-09-01 00:00:00
abstract：:A three-layer Newtonian model is investigated using a combined Eulerian-Lagrangian computational method to describe the dynamic behaviour of leukocytes. The model, composed of a cell membrane (outer layer), cytoplasm (middle layer) and nucleus (inner layer), can better describe the recovery characteristics because lar...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02510753
更新日期：1998-03-01 00:00:00
abstract：:Trabecular bone has a complicated porous microstructure and consists of interconnected plates and rods known as trabeculae. The microarchitecture of the trabeculae contributes to load distribution capacity and, particularly, the optimal bone strength. Many previous studies have shown that morphological parameters are ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-012-0951-3
更新日期：2012-10-01 00:00:00
abstract：:The study focuses on the problems of dimensionality reduction by means of principal component analysis (PCA) in the context of single-trial EEG data classification (i.e. discriminating between imagined left- and right-hand movement). The principal components with the highest variance, however, do not necessarily carry...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522476
更新日期：1998-05-01 00:00:00
abstract：:In the routine recording of magnetocardiograms (MCGs), it is necessary to underline the problem of noise cancellation. Source separation has often been suggested to solve this problem. In this paper, blind source separation (BSS), by means of singular value decomposition (SVD) and independent component analysis (ICA),...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-006-0055-z
更新日期：2006-06-01 00:00:00
abstract：:Self-generated mobility is a major contributor to the physical, emotional, cognitive, and social development of infants and toddlers. When young children have disorders that hinder self locomotion, their development is at risk for delay. Independent mobility via traditional power mobility devices may prevent this dela...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-011-0820-5
更新日期：2011-10-01 00:00:00
abstract：:A system is presented for the recording of physiological signals on an unmodified domestic videocassette recorder (VCR). A modification in the vertical synchronism pulses permits the recording of continuous analogue signals without significant loss of samples. The system allows up to 16 input channels, with a maximum ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02447101
更新日期：1991-03-01 00:00:00
abstract：:Electromyography (EMG) in a bio-driven system is used as a control signal, for driving a hand prosthesis or other wearable assistive devices. Processing to get informative drive signals involves three main modules: preprocessing, dimensionality reduction, and classification. This paper proposes a system for classifyin...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1857-5
更新日期：2018-12-01 00:00:00
abstract：:The paper explains the application of a genetic algorithm (GA) to the problem of estimating parameters for a kinetic model of a biologically reacting system. It is demonstrated that the GA is a powerful tool for quantifying the kinetic parameters using kinetic data. As the operation of the GA does not depend on the fo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02510391
更新日期：1997-01-01 00:00:00
abstract：:High-frequency nanosecond-pulsed electric fields were recently introduced for tumor or abnormal tissue ablation to solve some problems of conventional electroporation. However, it is necessary to study the thermal effects of high-field-intensity nanosecond pulses inside tissues. The multi-parametric analysis performed...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1589-3
更新日期：2017-07-01 00:00:00
abstract：:Automatic identification of landmarks in cephalometry is very important and useful for orthognathic surgery. A computerised automatic cephalometric analysis system (CACAS), based on image processing, is presented. For an original X-ray image, median filtering and histogram equalisation are used to improve image qualit...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345280
更新日期：2001-05-01 00:00:00
abstract：:The aim of this study was to develop a radiation-free method to measure gastric emptying. Such a method would be useful e.g. for patients who need repeated measurements and in pregnancy. Ferrimagnetic particles (gamma-Fe2O3), ingested within a solid test meal (pancakes), were magnetised by an applied magnetic field. A...
journal_title：Medical & biological engineering & computing
pub_type： 临床试验,杂志文章
doi：10.1007/BF02522849
更新日期：1998-01-01 00:00:00
abstract：:Haematocrit and temperature effects on resistivity are investigated using the electrical impedance method. Measurements are made extensively for pig's blood. The experimental set-up basically involves four ring electrodes being placed around a wooden probe that is subsequently immersed into a syringe containing pig's ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02523215
更新日期：1998-07-01 00:00:00
abstract：:In total hip arthroplasty, determining the impingement free range of motion requirement is a complex task. This is because in the native hip, motion is restricted by both impingement as well as soft tissue restraint. The aim of this study is to determine a range of motion benchmark which can identify motions which are...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-012-1016-3
更新日期：2013-04-01 00:00:00
abstract：:Sealing resistance is highly significant with respect to the electrical neuron-electrode contact because it decreases the stimulation threshold of neurons cultured on a planar micro-electrode array. A method is proposed for measurement of the sealing resistance using impedance spectroscopy. The effect of the sealing r...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02524436
更新日期：1998-09-01 00:00:00
abstract：:The software system GASepo has been developed as a tool to visualise and analyse doping (searching for performance-enhancing drugs in sports) with recombinant erythropoietin (rEpo). Digital images derived from the separation of Epo isoforms in gels by iso-electric focusing followed by double blotting and chemiluminesc...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345819
更新日期：2005-05-01 00:00:00
abstract：:Conventional methods of electrobioimpedance imaging are not suited for adequate visualization of the skin electrical impedance landscape (SEL) because they do not provide high spatial resolution at large enough area of view. The skin electrodynamics introscopy (SEI) enabled dynamic spectral imaging of the SEL at 32 × ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1668-0
更新日期：2018-02-01 00:00:00
abstract：:This study analyzes the performance of knee extension and flexion of Taekwondo and Kickboxing athletes. The power values were extracted through electromyography obtained by an isokinetic dynamometer at 60 degrees per second. These values are resulted from the square of the electromyography signal. The analysis of kick...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0608-z
更新日期：2010-06-01 00:00:00
abstract：:The development of an active implantable device for measuring electrocardiogram (ECG) is presented. The study is a part of a project which aims at developing implantable ECG instrumentation with wireless data and power transfer ( http://www.ele.tut.fi/tule ). The developed implant presented here has all the measuremen...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-007-0264-0
更新日期：2007-12-01 00:00:00
abstract：:A hydrodynamic model for the part of the human arterial network below the renal arteries has been constructed using specially fabricated distensible tubes and a pulsatile pump to simulate an aortoiliac bypass. The experiments and the computer model indicated that no 'steal' occurred due to the insertion of the bypass ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441802
更新日期：1993-11-01 00:00:00
abstract：:Detailed finite element (FE) models are used as promising tools to investigate traumatic brain injuries, although their accuracy is strongly dependent on the characterization of the mechanical behaviors of the different anatomic structures in the brain. In some cases, when the FE models require finer spatial resolutio...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1891-3
更新日期：2019-03-01 00:00:00
abstract：:Architectural distortion is a subtle abnormality in mammograms, and a source of overlooking errors by radiologists. Computer-aided diagnosis (CAD) techniques can improve the performance of radiologists in detecting masses and calcifications; however, most CAD systems have not been designed to detect architectural dist...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-006-0088-3
更新日期：2006-10-01 00:00:00
abstract：:A building block-based software framework was developed to simulate electrophysiological networks. The synaptic potentials generated during neurotransmission were simulated in an existing discrete bidomain model of smooth muscle, using cubic, three-dimensional grids of varying sizes. The model is automatically derived...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345322
更新日期：2003-09-01 00:00:00
abstract：:Neurofilaments are organised into parallel bundles in axons through crossbridges formed by lateral projections of neurofilament subunits. Pure neurofilaments form gels in vitro, consisting of interconnected parallel arrays of filaments regulated by the phosphorylation level of neurofilament subunits. Neurofilament-ass...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02522486
更新日期：1998-05-01 00:00:00
abstract：:We present a new, automatic, correlation-based method for measuring the duration of motor unit action potentials (MUAPs). The method seeks to replicate the way an expert elctromyographer uses his or her eyes, calculating the start and end of the MUAP waveform on the basis of the degree of similarity of non-excluded di...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02115-6
更新日期：2020-03-01 00:00:00
abstract：:In this paper, a method for apnea bradycardia detection in preterm infants is presented based on coupled hidden semi Markov model (CHSMM). CHSMM is a generalization of hidden Markov models (HMM) used for modeling mutual interactions among different observations of a stochastic process through using finite number of hi...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02277-8
更新日期：2021-01-01 00:00:00
