Abstract：
:Sealing resistance is highly significant with respect to the electrical neuron-electrode contact because it decreases the stimulation threshold of neurons cultured on a planar micro-electrode array. A method is proposed for measurement of the sealing resistance using impedance spectroscopy. The effect of the sealing resistance on the total impedance spectrum of a cell-electrode interface is modelled for complete coverage of the electrode by the cell. Sensitivity analysis demonstrates that the impedance spectrum is determined by four parameters: two electrode parameters, the sealing resistance and the shunt capacitance between the lead of the electrode and the culture medium. Experimental verification of the model is performed by simultaneous measurement of the impedance spectrum and electrode coverage. A good and unique fit between the simulated and measured impedance spectra was obtained by varying the two electrode parameters and the sealing resistance.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Buitenweg JR,Rutten WL,Willems WP,van Nieuwkasteele JWdoi
10.1007/BF02524436keywords:
subject
Has Abstractpub_date
1998-09-01 00:00:00pages
630-7issue
5eissn
0140-0118issn
1741-0444journal_volume
36pub_type
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