Relationships between the anti-HIV V(3)-derived peptide SPC(3) and lymphocyte membrane properties involved in virus entry: SPC(3) interferes with CXCR(4).

Abstract:

:SPC(3) is a multiple antigen peptide derived from the V(3) loop of human immunodeficiency virus (HIV) envelope (Env). It exerts a potent anti-HIV activity whereas it alters neither Env expression nor binding to CD(4). Here, SPC(3) binding characteristics, its subsequent intracellular fate and the fact that it inhibited SDF(1)alpha binding to the lymphocyte surface provided strong arguments to conclude that it exerts its anti-HIV activity through interference with the CXCR(4) coreceptor. In contrast, it interferes with none of the other major surface proteins and mechanisms involving V(3) and implicated in infection, as shown here. This work identifies the target mechanism of SPC(3).

journal_name

FEMS Microbiol Lett

authors

Barbouche R,Papandréou MJ,Miquelis R,Guieu R,Fenouillet E

doi

10.1111/j.1574-6968.2000.tb08964.x

keywords:

subject

Has Abstract

pub_date

2000-02-15 00:00:00

pages

235-40

issue

2

eissn

0378-1097

issn

1574-6968

pii

S0378-1097(99)00653-9

journal_volume

183

pub_type

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