Pressure-enhanced ortho-para conversion in solid hydrogen up to 58 GPa.

abstract：:The N-terminal domain of the vaccinia virus protein E3L (Z alpha(E3L)) is essential for full viral pathogenicity in mice. It has sequence similarity to the high-affinity human Z-DNA-binding domains Z alpha(ADAR1) and Z alpha(DLM1). Here, we report the solution structure of Z alpha(E3L) and the chemical shift map of it...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahmann JD,Wecking DA,Putter V,Lowenhaupt K,Kim YG,Schmieder P,Oschkinat H,Rich A,Schade M

更新日期：2004-03-02 00:00:00

abstract：:Visual information is conveyed from the eye to the brain by distinct types of retinal ganglion cells (RGCs). It is largely unknown how RGCs acquire their defining morphological and physiological features and connect to upstream and downstream synaptic partners. The three Brn3/Pou4f transcription factors (TFs) particip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sajgo S,Ghinia MG,Brooks M,Kretschmer F,Chuang K,Hiriyanna S,Wu Z,Popescu O,Badea TC

更新日期：2017-05-16 00:00:00

abstract：:The exopolysaccharide alginate is a major virulence factor in the pathogenicity of Pseudomonas aeruginosa infecting the lungs of cystic fibrosis (CF) patients. Alginate synthesis by P. aeruginosa is believed to occur in response to environmental signals present in the CF lung. Transcription of a critical alginate bios...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roychoudhury S,Sakai K,Chakrabarty AM

更新日期：1992-04-01 00:00:00

abstract：:Three distinct endosomal fractions were isolated in high purity from livers of estradiol-treated rats. Each fraction had characteristic physical and ultrastructural properties, but the lipid composition and major proteins of their membranes were similar and differed from those derived from the Golgi apparatus. Injecte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belcher JD,Hamilton RL,Brady SE,Hornick CA,Jaeckle S,Schneider WJ,Havel RJ

更新日期：1987-10-01 00:00:00

abstract：:During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Castro-Gomez S,Grendel J,Graf S,Süsens U,Binkle L,Mensching D,Isbrandt D,Kuhl D,Ohana O

更新日期：2018-12-04 00:00:00

abstract：:The functional architecture of mammalian visual cortex has been elucidated in impressive detail by experimental work of the past 20-25 years. The origin of many of the salient features of this architecture, however, has remained unexplained. This paper is the first of three (the others will appear in subsequent issues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linsker R

更新日期：1986-10-01 00:00:00

abstract：:We isolated mutant strains of the facultative anaerobe Salmonella typhimurium that grow either aerobically or anaerobically. Strict anaerobic mutants contained a defective DNA topoisomerase I gene (topI), while strict aerobic mutants contained a defective DNA gyrase subunit A gene (gyrA, also nalA). Topoisomerase I ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto N,Droffner ML

更新日期：1985-04-01 00:00:00

abstract：:Extensive terahertz laser vibration-rotation-tunneling spectra and mid-IR laser spectra have been compiled for several isotopomers of small (dimer through hexamer) water clusters. These data, in conjunction with new theoretical advances, quantify the structures, force fields, dipole moments, and hydrogen bond rearrang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keutsch FN,Saykally RJ

更新日期：2001-09-11 00:00:00

abstract：:Relatively low concentrations of methylxanthines increase spontaneous twitching in cultured muscle fibers; they also cause a second activity, escalation, which is the initiation and undiminished propagation of visible waves. The effect on twitching is abolished by depolarizing concentrations of K(+) or by tetrodotoxin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman AW,Coleman JR,Griffin JD,Weltman JK,Chapman KM

更新日期：1972-03-01 00:00:00

abstract：:The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhao D,Horie T,Chen G,Bao H,Chen S,Liu W,Horie R,Liang T,Dong B,Feng Q,Tao Q,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gee DG,Gabard-Durnam LJ,Flannery J,Goff B,Humphreys KL,Telzer EH,Hare TA,Bookheimer SY,Tottenham N

更新日期：2013-09-24 00:00:00

abstract：:The central administration of the fatty acid synthase (FAS) inhibitor, C75, rapidly suppresses the expression of orexigenic neuropeptides [neuropeptide Y (NPY) and agouti-related protein (AgRP)] and activates expression of anorexigenic neuropeptides [proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Z,Cha SH,van Haasteren G,Wang J,Lane MD

更新日期：2005-03-15 00:00:00

abstract：:Nuclear import of classical nuclear localization sequence-bearing proteins is mediated by karyopherin alpha/beta1 heterodimers. A second nuclear import pathway, mediated by karyopherin beta2 (transportin), recently was described for mRNA-binding proteins. Here we report the cloning and characterization of human karyop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yaseen NR,Blobel G

更新日期：1997-04-29 00:00:00

abstract：:The science around the use of masks by the public to impede COVID-19 transmission is advancing rapidly. In this narrative review, we develop an analytical framework to examine mask usage, synthesizing the relevant literature to inform multiple areas: population impact, transmission characteristics, source control, wea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howard J,Huang A,Li Z,Tufekci Z,Zdimal V,van der Westhuizen HM,von Delft A,Price A,Fridman L,Tang LH,Tang V,Watson GL,Bax CE,Shaikh R,Questier F,Hernandez D,Chu LF,Ramirez CM,Rimoin AW

更新日期：2021-01-26 00:00:00

abstract：:The S1-nuclease analysis was used to investigate the pattern of inhibin expression in the rat. In a first series of experiments, expression of the alpha, beta A, and beta B subunits of inhibin were monitored in various tissues from male and female rats. Two observations emerge from these studies. First, expression of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meunier H,Rivier C,Evans RM,Vale W

更新日期：1988-01-01 00:00:00

abstract：:In feeding, aphids inject saliva into plant tissues, gaining access to phloem sap and eliciting (and sometimes overcoming) plant responses. We are examining the involvement, in this aphid-plant interaction, of individual aphid proteins and enzymes, as identified in a salivary gland cDNA library. Here, we focus on a sa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mutti NS,Louis J,Pappan LK,Pappan K,Begum K,Chen MS,Park Y,Dittmer N,Marshall J,Reese JC,Reeck GR

更新日期：2008-07-22 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes malignant and inflammatory diseases in ∼10% of infected people. A typical host has between 10(4) and 10(5) clones of HTLV-1-infected T lymphocytes, each clone distinguished by the genomic integration site of the single-copy HTLV-1 provirus. The HTL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Satou Y,Miyazato P,Ishihara K,Yaguchi H,Melamed A,Miura M,Fukuda A,Nosaka K,Watanabe T,Rowan AG,Nakao M,Bangham CR

更新日期：2016-03-15 00:00:00

abstract：:After endocytosis, transmembrane cargo reaches endosomes, where it encounters complexes dedicated to opposing functions: recycling and degradation. Microdomains containing endosomal sorting complexes required for transport (ESCRT)-0 component Hrs [hepatocyte growth factor-regulated tyrosine kinase substrate (HGRS-1) i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Norris A,Tammineni P,Wang S,Gerdes J,Murr A,Kwan KY,Cai Q,Grant BD

更新日期：2017-01-17 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is a neurosteroid with potential effects on neurogenesis and neuronal survival in humans. However, most studies on DHEA have been performed in rodents, and there is little direct evidence for biological effects on the human nervous system. Furthermore, the mechanism of its action is unkno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki M,Wright LS,Marwah P,Lardy HA,Svendsen CN

更新日期：2004-03-02 00:00:00

abstract：:The proton-translocating subunit of wheat chloroplast ATP synthase is encoded by a chloroplast gene that has been accurately mapped and whose nucleotide sequence has been determined. The predicted sequence of 81 amino acids has been confirmed in part by determination of the sequence of the first 40 amino acids from th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howe CJ,Auffret AD,Doherty A,Bowman CM,Dyer TA,Gray JC

更新日期：1982-11-01 00:00:00

abstract：:Whether Golgi enzymes remain localized within the Golgi or constitutively cycle through the endoplasmic reticulum (ER) is unclear, yet is important for understanding Golgi dependence on the ER. Here, we demonstrate that the previously reported inefficient ER trapping of Golgi enzymes in a rapamycin-based assay results...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sengupta P,Satpute-Krishnan P,Seo AY,Burnette DT,Patterson GH,Lippincott-Schwartz J

更新日期：2015-12-08 00:00:00

abstract：:The Get3 ATPase directs the delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). TA-proteins are characterized by having a single transmembrane helix (TM) at their extreme C terminus and include many essential proteins, such as SNAREs, apoptosis factors, and protein translocation components. Thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suloway CJ,Chartron JW,Zaslaver M,Clemons WM Jr

更新日期：2009-09-01 00:00:00

abstract：:The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region kappa chain (V kappa) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one V kappa sequence, the homology includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen PP,Kabat EA,Wu TT,Fong S,Carson DA

更新日期：1985-04-01 00:00:00

abstract：:Diisopropyl fluorophosphate (DFP) causes neurotoxicity related to an irreversible inhibition of acetylcholinesterase (AChE). Management of this intoxication includes: (i) pretreatment with reversible blockers of AChE, (ii) blockade of muscarinic receptors with atropine, and (iii) facilitation of GABA(A) receptor signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pibiri F,Kozikowski AP,Pinna G,Auta J,Kadriu B,Costa E,Guidotti A

更新日期：2008-09-16 00:00:00

abstract：:Increased cardiovascular mortality occurs in diabetic patients with or without coronary artery disease and is attributed to the presence of diabetic cardiomyopathy. One potential mechanism is hyperglycemia that has been reported to activate protein kinase C (PKC), preferentially the beta isoform, which has been associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakasaki H,Koya D,Schoen FJ,Jirousek MR,Ways DK,Hoit BD,Walsh RA,King GL

更新日期：1997-08-19 00:00:00

abstract：:The substitution pattern of anthocyanin pigments is a main determinant of flower color. Flavonoid 3',5'-hydroxylase (F3'5'H) is a cytochrome P450 enzyme (Cyt P450) that catalyzes the 3', 5'-hydroxylation of dihydroflavonols, the precursors of purple anthocyanins. Species such as rose and carnation lack F3'5'H activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Vetten N,ter Horst J,van Schaik HP,de Boer A,Mol J,Koes R

更新日期：1999-01-19 00:00:00

abstract：:Setting aside high-quality large areas of habitat to protect threatened populations is becoming increasingly difficult as humans fragment and degrade the environment. Biologists and managers therefore must determine the best way to shepherd small populations through the dual challenges of reductions in both the number...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hufbauer RA,Szűcs M,Kasyon E,Youngberg C,Koontz MJ,Richards C,Tuff T,Melbourne BA

更新日期：2015-08-18 00:00:00

abstract：:In this paper we demonstrate that near infrared Fourier transform Raman spectroscopy provides unprecedented biochemical information about the extent of atherosclerosis in human aorta. In particular, elastin, collagen, cholesterol, cholesterol esters, lipids, carotenoids, and calcium apatite deposits all can be discern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraga JJ,Feld MS,Rava RP

更新日期：1992-04-15 00:00:00

abstract：:The bottom-up design of protein-based signaling networks is a key goal of synthetic biology; yet, it remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Here, we report a generic approach for the construction of protein-base...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein V,Alexandrov K

更新日期：2014-11-11 00:00:00

abstract：:Dysregulation of cyclin-dependent kinase 5 (cdk5) per relative concentrations of its activators p35 and p25 is implicated in neurodegenerative diseases. P35 has a short t½ and undergoes rapid proteasomal degradation in its membrane-bound myristoylated form. P35 is converted by calpain to p25, which, along with an exte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai SY,Pokrass MJ,Klauer NR,Nohara H,Su TP

更新日期：2015-05-26 00:00:00