Abstract:
BACKGROUND:To assess the impact of water sanitation and sewage disposal, part of a major environmental control programme in Rio de Janeiro, we carried out sero-prevalence studies for Hepatitis A virus (HAV) in three micro-regions in Rio de Janeiro. Each region varied with regard to level of sanitation. We are interested in assessing the discriminating power of age-specific prevalence curves for HAV as a proxy for improvement in sanitation. These curves will serve as baseline information to future planned surveys as the sanitation programme progresses. METHODS:Incidence rate curves from prevalence data are estimated parametrically via a Weibull-like survival function, and non-parametrically via maximum likelihood and monotonic splines. Sera collected from children and adults in the three areas are used to detect antibodies against HAV through ELISA. RESULTS:We compare baseline incidence curves at the three sites estimated by the three methods. We observe a strong negative correlation between level of sanitation and incidence rates for HAV infection. Incidence estimates yielded by the parametric and non-parametric approaches tend to agree at early ages in the microregion showing the best level of sanitation and to increasingly disagree in the other two. CONCLUSION:Our results support the choice of HAV as a sentinel disease that is associated with level of sanitation. We also introduce monotonic splines as a novel non-parametric approach to estimate incidence from prevalence data. This approach outperforms current estimating procedures.
journal_name
Int J Epidemioljournal_title
International journal of epidemiologyauthors
Struchiner CJ,de Almeida LM,de Azevedo RS,Massad Edoi
10.1093/ije/28.4.776keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
776-81issue
4eissn
0300-5771issn
1464-3685journal_volume
28pub_type
杂志文章abstract:BACKGROUND:Although individual studies have been inconsistent, meta-analyses of epidemiological data suggest that high folate and vitamin B12 levels may be associated with increased prostate cancer risk. METHODS:Within JANUS, a prospective cohort in Norway (n = 317 000) with baseline serum samples, we conducted a nest...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dys199
更新日期:2013-02-01 00:00:00
abstract::This article investigates the interrelationship of socioeconemic status, anthropometric status and mortality of young children in rural Bangladesh. Data for this study come from Matlab, the vital registration area of the International Centre for Diarrhoeal Disease Research, Bangladesh, where anthropometric and socioec...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/23.6.1179
更新日期:1994-12-01 00:00:00
abstract::A serological survey of 300 Israeli intravenous drug addicts in 1988-1989, showed a 2.3% prevalence of antibodies to human immunodeficiency virus (HIV), very similar to the finding of a previous study (2%) performed in the same population in 1986. Travel and drug injection abroad continue to be the most significant pr...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/21.3.561
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:To explore whether causes of maternal death can be investigated using the sisterhood method, an indirect method for providing a community-based estimate of the level of maternal mortality, this study compares the sisterhood causes of maternal death with the Matlab Demographic Surveillance System's (DSS) caus...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/24.5.937
更新日期:1995-10-01 00:00:00
abstract::High-income countries are experiencing an obesity epidemic that follows a socioeconomic gradient, affecting groups of lower socioeconomic status disproportionately. Recent clinical findings have suggested new perspectives for the prevention and treatment of obesity, using personalized dietary approaches. Precision nut...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy274
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:The majority of tuberculosis (TB) cases in low-incidence countries occur in migrants. Only few studies have assessed the long-term TB risk in migrants after immigration, and datasets have not considered this across a range of diverse migrant groups. This nationwide study aimed to investigate long-term TB ris...
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pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Depression has been associated with chronic changes in the serum concentration of C-reactive protein (CRP) in observational studies, but it is unclear if this association is causal or is due to confounding and bias. Genetic studies are less subject to this type of error and offer an opportunity to investigat...
journal_title:International journal of epidemiology
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doi:10.1093/ije/dyp199
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Samples of railroad male employees aged 40-59 were examined from companies operating in the northwest quadrant of the US in the late 1950s (n = 2571), and in Rome and surroundings. Italy in the early 1960s (n = 768) in an international co-operative study on cardiovascular diseases. METHODS:A number of cardi...
journal_title:International journal of epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1093/ije/24.3.515
更新日期:1995-06-01 00:00:00
abstract::An analysis is made of the association between density factors and the profile of cause specific death rates in small areas (Bezirke) of Hannover, Germany, in 1968-69. Evaluation of urban ecological methods and logic is done to determine the plausibility of making meaningful statements about cause specific death risks...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/6.3.203
更新日期:1977-09-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/17.1.222
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:The long average incubation time from HIV infection to AIDS makes it difficult to estimate recent HIV transmission from AIDS incidence data. Age-period-cohort (APC) analysis can separate out the effects of age, calendar time and birth cohort to provide a clearer picture of transmission trends. METHODS:AIDS ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/28.6.1141
更新日期:1999-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.supplement_1.s73
更新日期:1990-01-01 00:00:00
abstract::Interest has recently emerged about the increasing trend of pancreatic cancer mortality in Taiwan, particularly in the elderly. The mortality data of pancreatic cancer over the period 1971-1986 for males and females aged 40-84 in Taiwan were analysed using a log-linear Poisson model to examine the effects of age, cale...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/19.4.839
更新日期:1990-12-01 00:00:00
abstract:BACKGROUND:The prevalence of obesity has increased rapidly in most developed countries in the last decades, and this rise is now spreading to developing countries. Childhood obesity is also increasing. The UK government has set a target to halt the rise in childhood obesity by 2010. Dietary recommendations are a centra...
journal_title:International journal of epidemiology
pub_type: 杂志文章,评审
doi:10.1093/ije/dyl208
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Recently, using a counterfactual framework, a causal mediation analysis has been formalized to decompose the total effect of a time-fixed exposure on an outcome into four components that can be loosely defined as being components due to mediation only, interaction only, mediated interaction and neither. The ...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyy252
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Mortality was compared in the Jewish populations of Montreal and Israel and the overall Canadian population, to investigate whether the Israeli pattern of low male mortality and relatively high female mortality is replicated among Jews living elsewhere. METHODS:In Montreal, death certificates were obtained ...
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pub_type: 杂志文章
doi:10.1093/ije/24.4.730
更新日期:1995-08-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyt014
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Ready-made spectacles (RMS) have advantages; however, visual performance and satisfaction has not been evaluated. METHODS:A 1-month, double-masked, randomized clinical trial comparing planned continued use and visual performance of RMS to Custom Spectacles (CS) in adults aged 18-45 years with > or =1 diopte...
journal_title:International journal of epidemiology
pub_type: 杂志文章,随机对照试验
doi:10.1093/ije/dyp384
更新日期:2010-06-01 00:00:00
abstract::The relationship between body fat and different aspects of glucose tolerance was examined within the Zutphen Study. In 1970 an oral glucose tolerance test (OGTT) was carried out in 404 non-diabetic men aged 50-70. None of the subjects could be classified as having impaired glucose tolerance. Body mass index (BMI), sub...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.2.368
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Increases in measles antibodies without rash-illnesses have been documented in previously vaccinated children exposed to measles cases. The phenomenon has been incompletely evaluated in young unvaccinated infants with immunity of maternal origin. METHODS:Monthly cohorts of newborns were prospectively random...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/28.1.147
更新日期:1999-02-01 00:00:00
abstract::The European Prospective Investigation of Cancer (EPIC) is a 10-country collaborative study in which EPIC-Norfolk is one of the UK centres. EPIC-Norfolk examined 25 639 men and women resident in East Anglia (aged 40-79 years), between 1993 and 1997. The EPIC collaboration was set up to examine the dietary determinants...
journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ije/13.1.25
更新日期:1984-03-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/18.3.717
更新日期:1989-09-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Trisomy 18 (Edwards' syndrome, T18) is the second most common trisomy in man. We describe 118 children with regular T18 who were ascertained clinically and cytogenetically in the Kuwait Medical Genetics Centre during 1980-1997. METHODS:Ascertainment of T18 cases was performed shortly after birth. Chromosoma...
journal_title:International journal of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ije/28.4.711
更新日期:1999-08-01 00:00:00
abstract::The published data for overall cancer incidence for the registries of Birmingham (UK) and Connecticut (US) show remarkable similarity for men but diverge for women. The incidence of cancer of the endometrium, ovary and breast in Connecticut is higher than in Birmingham, and in each case the menopausal dislocation in t...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/5.3.231
更新日期:1976-09-01 00:00:00
abstract:BACKGROUND:Spot checks are becoming a popular method to assess hygiene behaviours; however, little is known about their repeatability or predictability. We evaluated the within-household repeatability of hygiene indices created from spot checks and their ability to predict incidence of diarrhoea in young Guatemalan chi...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/dyl165
更新日期:2006-12-01 00:00:00
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journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/22.5.898
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:While dietary patterns that are both predictive of chronic disease and mortality have been identified, the confounding effects of cardiorespiratory fitness have not been properly addressed. The primary objective was to assess the relation between dietary patterns with all-cause mortality, while controlling f...
journal_title:International journal of epidemiology
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Recent communications have argued that often it may not be appropriate to analyse cross-sectional studies of prevalent outcomes with logistic regression models. The purpose of this communication is to compare three methods that have been proposed for application to cross sectional studies: (1) a multiplicati...
journal_title:International journal of epidemiology
pub_type: 杂志文章
doi:10.1093/ije/27.1.91
更新日期:1998-02-01 00:00:00